Results 1 to 10 of about 7,684 (200)

FOXL2 + cancer-associated fibroblasts enhances epithelial ovarian cancer development via TGFβ/Smad signaling [PDF]

BMC Cancer
Background FOXL2, a key regulator of ovarian development, is linked to ovarian disorders, but its role in epithelial ovarian cancer (EOC) remains unclear.
Lei Zhao, Jingqi Nie, Jinming Wang, Dongliang Li, Xuewei Hao   +4 more
doaj   +2 more sources

Hyperandrogenism in polycystic ovary syndrome augments Estrogen synthesis through AR-FOXL2–mediated activation of the aromatase gene in granulosa cells [PDF]

Journal of Ovarian Research
Background Polycystic ovary syndrome (PCOS) is a complex disorder characterized by various reproductive, metabolic, and endocrine abnormalities. Hyperandrogenism is a key feature of PCOS that significantly impacts ovarian function.
Yi-Ru Tsai, Yen-Nung Liao, Cheng-Ju Tsai, Yu-Ang Lee, Shih-Min Hsia, Kuo-Chung Lan, Hong-Yo Kang   +6 more
doaj   +2 more sources

FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development [PDF]

Reproductive Biology and Endocrinology
Background Forkhead box L2 (FOXL2) is a transcription factor from the forkhead box family primarily expressed in the pituitary, ovaries, and eyelids. Human mutations in FOXL2 cause blepharophimosis, ptosis, epicanthus and inversus syndrome (BPES), which ...
Laura Danti, Karolina Lundin, Petra Nedeczey-Ruzsák, Timo Tuuri, Juha S. Tapanainen   +4 more
doaj   +2 more sources

Regulation of FOXL2 gene in ovarian granulosa cell tumor by JNK inhibitor [PDF]

Scientific Reports
To explore the regulatory effect of c-Jun N-terminal kinase (JNK) inhibitor (SP600125) on forkhead box protein L2 (FOXL2) gene in human ovarian granulosa cell tumor cells (KGN cells).
Yuzhu Zhang, Yu Wang, Yuan Gu, Yang Liu, Guohua Liu, Jun Wu, Nan Bai   +6 more
doaj   +2 more sources

Comparative transcriptome analysis reveals involvement of FOXL2 in regulation of ovulation cycle in chicken [PDF]

Poultry Science
The egg-laying performance is closely related to ovulation of chicken. Ovulation is very complex and highly coordinated physiological process. However, little is known about the ovulation-related synergistic actions of molecules and their signaling. Here,
Xuelian Li, Haobo Zhou, Wei Luo, Xuliang Luo, Xiaxia Zhang, Zi Mei, Yanzhang Gong   +6 more
doaj   +2 more sources

Reference genome provide insights into sex determination of silver aworana (Osteoglossum bicirrhosum) [PDF]

BMC Biology
Background Silver arowana (Osteoglossum bicirrhosum) is a basal fish species with sexual monomorphism, while its sex determination mechanism has been poorly understood, posing a significant challenge to its captive breeding efforts.
Yi Liu, Chao Bian, Ka Yan Ma, Yexin Yang, Yuanyuan Wang, Chao Liu, Guochang Ouyang, Meng Xu, Jinhui Sun, Changwei Shao, Jiehu Chen, Qiong Shi, Xidong Mu   +12 more
doaj   +2 more sources

Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. [PDF]

, 2014
In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene ...
Arriola, David J, Park, Chung Hyun, Rivera, Alissa J, Skarra, Danalea V, Thackray, Varykina G   +4 more
core   +21 more sources

Identification of a novel FOXL2 mutation in a fourth-generation Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome [PDF]

International Journal of Ophthalmology, 2021
AIM: To characterize the genetic causes and clinical features in a four-generation Chinese family with blepharophimosis-ptosis-epicanthus inversus syndrome (BPES).
Wei-Ning Rong, Mei-Jiao Ma, Wei Yang, Shi-Qin Yuan, Xun-Lun Sheng   +4 more
doaj   +1 more source

Forkhead box L2 is a target of miR‐133b and plays an important role in the pathogenesis of non‐small cell lung cancer

Cancer Medicine, 2023
Background Forkhead box L2 (FOXL2) has been recognized as a transcription factor in the progression of many malignancies, but its role in non‐small cell lung cancer (NSCLC) remains unclear.
Juan Li, Lirong Gao, Anqi Wang, Huiwen Qian, Jianjie Zhu, Shundong Ji, Jun Chen, Zeyi Liu, Cheng Ji   +8 more
doaj   +1 more source

Microhomology-mediated mechanisms underlie non-recurrent disease-causing microdeletions of the FOXL2 gene or its regulatory domain [PDF]

, 2013
Genomic disorders are often caused by recurrent copy number variations (CNVs), with nonallelic homologous recombination (NAHR) as the underlying mechanism.
BEYSEN, DIANE, Carvalho, Claudio MB, D'haene, Barbara, De Baere, Elfride, Lapunzina, Pablo, Lupski, James R, Menten, Björn, Nevado, Julian, Novikova, Yana, Sante, Tom, Verdin, Hannah   +10 more
core   +11 more sources