Results 11 to 20 of about 7,684 (200)

New STAT3-FOXL2 pathway and its function in cancer cells [PDF]

BMC Molecular and Cell Biology, 2019
Background The forkhead transcription factor (FOXL2) plays a crucial role in blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), sex determination, ovary growth and development, and cell cycle regulation.
Yangyang Han, Jun Wu, Weiwei Yang, Di Wang, Tianliang Zhang, Min Cheng   +5 more
doaj   +3 more sources

Structure, evolution and expression of the FOXL2 transcription unit [PDF]

Cytogenetic and Genome Research, 2003
FOXL2 is a putative transcription factor involved in ovarian development and function. Its mutations in humans are responsible for the blepharophimosis syndrome, characterized by eyelid malformations and premature ovarian failure (POF). Here we have performed a comparative sequence analysis of FOXL2 sequences of ten vertebrate species.
COCQUET, J, De Baere, Elfride, FELLOUS, M, GAREIL, M, PANNETIER, M, VEITIA, RA, XIA, X   +6 more
core   +5 more sources

Phase II clinical trial of nirogacestat in patients with relapsed ovarian granulosa cell tumours. [PDF]

Clin Transl Med
Evidence suggests NOTCH activation is among the survival and proliferation pathways interacting with FOXL2 c.402C > G (p.Cys134Trp) mutation in granulosa cell tumours (GCT). This Phase II clinical trial of nirogacestat in GCT achieved its enrolment target in < 1 year and primary analysis within 2 years.
Grisham RN, Hopp E, Pennington K, Holloway R, Wenham RM, Blecharz P, Dockery L, Matsuo K, Salani R, Bidzinski M, Braly P, Celano P, Reid T, Seward S, Lewis J, Johnson M, DuBose R, Ahn S, Cheng S, Alvero C, Konstantinopoulos PA.   +20 more
europepmc   +2 more sources

Cooperative effects of oocytes and estrogen on the forkhead box L2 expression in mural granulosa cells in mice

Scientific Reports, 2022
Forkhead box L2 (FOXL2) plays a critical role in the development and function of mammalian ovaries. In fact, the causative effects of FOXL2 misregulations have been identified in many ovarian diseases, such as primary ovarian insufficiency and granulosa ...
Haruka Ito, Chihiro Emori, Mei Kobayashi, Natsumi Maruyama, Wataru Fujii, Kunihiko Naito, Koji Sugiura   +6 more
doaj   +1 more source

Evolution and expression of FOXL2 [PDF]

Journal of Medical Genetics, 2002
Mutations in the FOXL2 gene have recently been shown to cause the blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), a rare genetic disease (MIM 110100).1 In type I BPES eyelid abnormalities are associated with premature ovarian failure (POF), while in type II BPES only the eyelid malformation is observed.2 FOXL2 is the first human autosomal ...
Cocquet, J., Pailhoux, Eric, Jaubert, F., Servel, N., Xia, X., Pannetier, Maëlle, de Baere, E., Messiaen, L., Cotinot, Corinne, Fellous, Marc, Veitia, R.A.   +10 more
openaire   +3 more sources

The transcriptional targets of mutant FOXL2 in granulosa cell tumours. [PDF]

PLoS ONE, 2012
BACKGROUND: Despite their distinct biology, granulosa cell tumours (GCTs) are treated the same as other ovarian tumours. Intriguingly, a recurring somatic mutation in the transcription factor Forkhead Box L2 (FOXL2) 402C>G has been found in nearly all ...
Roseanne Rosario, Hiromitsu Araki, Cristin G Print, Andrew N Shelling   +3 more
doaj   +1 more source

Increased FOXL2 Expression Alters Uterine Structures and Functions [PDF]

Biology of Reproduction, 2020
AbstractTranscription factor FOXL2 exhibits an increase in mRNA levels in eutopic endometrial biopsy in endometriosis patients. While FOXL2 is known of regulating sex differentiation and reproductive function, the impact of elevated FOXL2 expression on uterine physiology remains unknown.
Li, Rong, Wu, San-Pin, Zhou, Lecong, Nicol, Barbara, Lydon, John P., Yao, Humphrey H-C, DeMayo, Francesco J.   +6 more
openaire   +2 more sources

Transcriptome sequencing revealed that knocking down FOXL2 affected cell proliferation, the cell cycle, and DNA replication in chicken pre-ovulatory follicle cells.

PLoS ONE, 2020
Forkhead box L2 (FOXL2) is a single-exon gene encoding a forkhead transcription factor, which is mainly expressed in the ovary, eyelids and the pituitary gland. FOXL2 plays an essential role in ovarian development.
Wei Luo, Lantao Gu, Jinqiu Li, Yanzhang Gong   +3 more
doaj   +1 more source

FOXL2, GATA4, and SMAD3 co-operatively modulate gene expression, cell viability and apoptosis in ovarian granulosa cell tumor cells. [PDF]

PLoS ONE, 2014
Aberrant ovarian granulosa cell proliferation and apoptosis may lead to granulosa cell tumors (GCT), the pathogenesis of which involves transcription factors GATA4, FOXL2, and SMAD3. FOXL2 gene harbors a point mutation (C134W) in a vast majority of GCTs.
Mikko Anttonen, Marjut Pihlajoki, Noora Andersson, Adrien Georges, David L'hôte, Sanna Vattulainen, Anniina Färkkilä, Leila Unkila-Kallio, Reiner A Veitia, Markku Heikinheimo   +9 more
doaj   +1 more source

Identification and functional analyses of a novel FOXL2 pathogenic variant causing blepharophimosis, ptosis, and epicanthus inversus syndrome [PDF]

International Journal of Ophthalmology, 2023
AIM: To discover the molecular pathogenic basis of the blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES), and to predict the clinical subtype according to in vitro experiments, which is significant to the prognosis.
Yu-Cheng Yan, Lu Zhou, Jin-Cai Fan
doaj   +1 more source