Results 21 to 30 of about 7,684 (200)

SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies. [PDF]

PLoS ONE, 2011
BACKGROUND: FOXL2 is a transcription factor essential for ovarian development and maintenance. It is mutated in the genetic condition called Blepharophimosis Ptosis Epicantus inversus Syndrome (BPES) and in cases of isolated premature ovarian failure. We
Adrien Georges, Bérénice A Benayoun, Mara Marongiu, Aurélie Dipietromaria, David L'Hôte, Anne-Laure Todeschini, Jana Auer, Laura Crisponi, Reiner A Veitia   +8 more
doaj   +1 more source

Transcription factors foxl2 and foxl3 regulate cyp19a1a and cyp11b in orange-spotted grouper (Epinephelus coioides)

Aquaculture Reports, 2022
In orange-spotted grouper (E. coioides), the transcription factors foxl2 and foxl3 are thought to play an important role in ovarian and testicular development, but how they do so remains unclear.
Chunli Zhang, Qi He, Huitao Cheng, Lihua Li, Xinhe Ruan, Xuzhuo Duan, Fengqi Huang, Huirong Yang, Haifa Zhang, Herong Shi, Qing Wang, Huihong Zhao   +11 more
doaj   +1 more source

Functional analysis of 6 variations in <i>FOXL2</i>. [PDF]

SAGE Open Med
Objective: We aimed to investigate the functional alterations caused by pathogenic variants in the FOXL2 gene, a forkhead transcriptional factor. Methods: This study is an experimental research with a duration from January to ...
Wang Y, Wu Q, Zhou Y, Liu W, Cao W, Fan Y, Li N.   +6 more
europepmc   +3 more sources

Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads [PDF]

Human Molecular Genetics, 2018
The identity of the gonads is determined by which fate, ovarian granulosa cell or testicular Sertoli cell, the bipotential somatic cell precursors choose to follow. In most vertebrates, the conserved transcription factor FOXL2 contributes to the fate of granulosa cells.
Barbara Nicol, Sara A Grimm, Artiom Gruzdev, Greg J Scott, Manas K Ray, Humphrey H-C Yao   +5 more
openaire   +2 more sources

FoxL2 and Smad3 Coordinately Regulate Follistatin Gene Transcription [PDF]

Journal of Biological Chemistry, 2009
Follistatin is a transcriptional target and a modulator of activin action. Through an autocrine/paracrine loop, activin controls follistatin levels and thus regulates its own bioavailability. In gonadotropic alphaT3-1 cells, activin induces follistatin transcription primarily through the action of Smad3 at an intronic Smad-binding element (SBE1). Using
Amy L, Blount, Karsten, Schmidt, Nicholas J, Justice, Wylie W, Vale, Wolfgang H, Fischer, Louise M, Bilezikjian   +5 more
openaire   +2 more sources

Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. [PDF]

, 2014
We previously identified FOXL2 as a critical component in FSHβ gene transcription. Here, we show that mice deficient in FOXL2 have lower levels of gonadotropin gene expression and fewer LH- and FSH-containing cells, but the same level of other pituitary ...
Barakat, Nermeen H, Breen, Kellie M, Coss, Djurdjica, Hambarchyan, Arpi, Meadows, Jason D, Mellon, Pamela L, Pepa, Patricia A, Roybal, Lacey L   +7 more
core   +1 more source

Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

Journal of Ovarian Research, 2010
Background The Foxl2 transcription factor is required for ovarian function during follicular development. The mechanism of Foxl2 regulation of this process has not been elucidated.
Escudero Jean M, Haller Jodi L, Clay Colin M, Escudero Kenneth W   +3 more
doaj   +1 more source

Associations between forkhead box l2 expression and ovary development in laying hens [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
Make sure healthy ovary or follicle is critical for extending egg laying performance in poultry. Transcription factor forkhead box L2 (FOXL2) gene have key role in regulate development of ovary.
Shouping ZHANG, Xiaojing XIA, Lirong WANG, Renfeng LI, Meng YANG, Sanhu WANG   +5 more
doaj   +1 more source

A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development [PDF]

, 2011
Disorders of sex development (DSD) are congenital conditions where chromosomal, gonad or genital development is atypical. In a significant proportion of 46,XY DSD cases it is not possible to identify a causative mutation, making genetic counseling ...
AJ Notini, AJ Paige, AK Bednarek, Andrew Sinclair, D Wilhelm, DM Maatouk, E Sutton, Erin Turbitt, H Stoop, Jacqueline Hewitt, JH Ludes-Meyers, Leendert Looijenga, LH Looijenga, M Cools, M Cools, Martine Cools, MI Nunez, N Bouteille, PA Lee, Peter Koopman, R Hersmus, Remko Hersmus, RI Aqeilan, RI Aqeilan, RI Aqeilan, RI Aqeilan, S Del Mare, SJ White, SJ White, Stefan White, Stenvert Drop, Vincent Harley, Yvonne van der Zwan   +32 more
core   +1 more source

The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.

PLoS ONE, 2010
The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure.
Mara Marongiu, Manila Deiana, Alessandra Meloni, Loredana Marcia, Alessandro Puddu, Antonio Cao, David Schlessinger, Laura Crisponi   +7 more
doaj   +1 more source