Results 51 to 60 of about 7,684 (200)
Sense and antisense Foxl2 transcripts in mouse
Genomics, 2005 FOXL2 is a forkhead transcription factor involved in eyelid development and in the development and adult function of the ovary in mammals. In mouse, we have previously suggested the existence of two mRNA isoforms of Foxl2 that result from an alternative polyadenylation.
Cocquet, J. +3 more
openaire +4 more sources
eLife, 2014 FOXL2 is a lineage determining transcription factor in the ovary, but its direct targets and modes of action are not fully characterized. In this study, we explore the targets of FOXL2 and five nuclear receptors in murine primary follicular cells.
Adrien Georges +6 more
doaj +1 more source
expression might be a novel prognostic biomarker in patients with laryngeal squamous cell carcinoma
Journal of International Medical Research, 2020 Objectives This study aimed to explore the expression profile of the Forkhead box protein L2 gene ( FOXL2 ) and to determine its prognostic value and associated epigenetic and genetic alterations in patients with laryngeal squamous cell carcinoma (LSCC).
Jun Ge +5 more
doaj +1 more source
Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. [PDF]
, 2017 BackgroundProper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development, leading to ...
Brayman, Melissa J +6 more
core +3 more sources
Biology, 2022 Foxl2 is an evolutionarily conserved female sex gene, which is specifically expressed in the ovary and mainly involved in oogenesis and ovarian function maintenance.
Shutong Fan +6 more
doaj +1 more source
RNF40 regulates gene expression in an epigenetic context-dependent manner [PDF]
, 2017 Background Monoubiquitination of H2B (H2Bub1) is a largely enigmatic histone modification that has been linked to transcriptional elongation. Because of this association, it has been commonly assumed that H2Bub1 is an exclusively positively acting ...
Adam Grundhoff +12 more
core +2 more sources
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target
JCI Insight, 2020 Granulosa cell tumors (GCT) are rare ovarian malignancies. Due to the lack of effective treatment in late relapse, there is a clear unmet need for novel therapies.
Stefano Pierini +8 more
doaj +1 more source
Overexpression of wild-type but not C134W mutant FOXL2 enhances GnRH-induced cell apoptosis by increasing GnRH receptor expression in human granulosa cell tumors. [PDF]
PLoS ONE, 2013 The etiology of granulosa cell tumors (GCTs) is largely unknown. The primary mode of treatment is surgical, however not all women are cured by surgery alone.
Jung-Chien Cheng +2 more
doaj +1 more source
Disturbed Ovarian Differentiation in XX;SRY-Negative Dogs [PDF]
, 2019 In a mammal, at the beginning of its development, the gonad is bipotential. The shift into a male or female pathway is coordinated by the sex chromosomal complement, which triggers a series of genetic pathways signaling the developmental pattern of the ...
Payan-Carreira, Rita
core +1 more source
Germ line control of female sex determination in zebrafish [PDF]
, 2008 A major transition during development of the gonad is commitment from an undifferentiated “bi-potential” state to ovary or testis fate. In mammals, the oogonia of the developing ovary are known to be important for folliculogenesis.
Nüsslein-Volhard, Christiane +1 more
core +1 more source