Results 61 to 70 of about 7,684 (200)

FOXL2 in the Pituitary: Molecular, Genetic, and Developmental Analysis [PDF]

Molecular Endocrinology, 2006
FOXL2 is a forkhead transcription factor expressed in the eye, ovary, and pituitary gland. Loss of function mutations in humans and mice confirm a functional role for FOXL2 in the eye and ovary, but its role in the pituitary is not yet defined. We report that FOXL2 colocalizes with the glycoprotein hormone alpha-subunit (alphaGSU) in quiescent cells of
Buffy S, Ellsworth, Noboru, Egashira, Jodi L, Haller, Darcy L, Butts, Julie, Cocquet, Colin M, Clay, Robert Y, Osamura, Sally A, Camper   +7 more
openaire   +2 more sources

Functional Studies of Novel FOXL2 Variants in Chinese Families With Blepharophimosis–Ptosis–Epicanthus Inversus Syndrome

Frontiers in Genetics, 2021
The blepharophimosis–ptosis–epicanthus inversus syndrome (BPES) is a rare autosomal dominant disease mainly caused by FOXL2 variants. This genetic disorder is usually characterized by eyelid malformation and ovarian dysfunction.
Fang Li, Fang Li, Huifang Chen, Huifang Chen, Yefei Wang, Yefei Wang, Jie Yang, Jie Yang, Yixiong Zhou, Yixiong Zhou, Xin Song, Xin Song, Jiayan Fan, Jiayan Fan   +13 more
doaj   +1 more source

The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations [PDF]

, 2015
Synthetic progestins have become widespread environmental contaminants and may cause adverse effects on fish. In the present study, we investigated the effects of levonorgestrel (LNG) on sex differentiation in zebrafish (Danio rerio).
Guo, Yongyong, Han, Jian, Hua, Jianghuan, Zhou, Bingsheng   +3 more
core   +1 more source

Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1 [PDF]

, 2015
Genes related to Dmrt1, which encodes a DNA-binding DM domain transcription factor, act as triggers for primary sex determination in a broad range of metazoan species.
Koopman, Peter, Svingen, Terje, Ting Ng, Ee, Zhao, Liang   +3 more
core   +2 more sources

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Foxl2 functions in sex determination and histogenesis throughout mouse ovary development [PDF]

, 2009
Background. Partial loss of function of the transcription factor FOXL2 leads to premature ovarian failure in women. In animal models, Foxl2 is required for maintenance, and possibly induction, of female sex determination independently of other critical ...
Antonino Forabosco, Antonio Cao, Chris Ottolenghi, David Schlessinger, Emanuele Pelosi, Jesse Karmazin, José Garcia-Ortiz, Manuela Uda, Shakib Omari, Steve W Cole, Timur Nedorezov, Yulan Piao   +11 more
core   +2 more sources

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

The transcription factor FOXL2 in ovarian function and dysfunction.

Folia Histochemica et Cytobiologica, 2010
The Blepharophimosis Ptosis Epicanthus-inversus Syndrome is a genetic disease characterized by complex eyelid malformations often associated with premature ovarian failure (POF).
Elfride De Baere, Marc Fellous, Reiner A Veitia   +2 more
doaj   +1 more source

FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Müllerian Hormone in Human Granulosa Cells. [PDF]

PLoS ONE, 2016
Anti-Müllerian hormone (AMH) is required for proper sexual differentiation by regulating the regression of the Müllerian ducts in males. Recent studies indicate that AMH could be an important factor for maintaining the ovarian reserve.
Hanyong Jin, Miae Won, Si Eun Park, Seunghwa Lee, Mira Park, Jeehyeon Bae   +5 more
doaj   +1 more source

Fine map of the Gct1 spontaneous ovarian granulosa cell tumor locus [PDF]

, 2012
The spontaneous development of juvenile-onset, ovarian granulosa cell (GC) tumors in the SWR/Bm (SWR) inbred mouse strain is a model for juvenile-type GC tumors that appear in infants and young girls.
Ann M. Dorward, Edward S. Yaskowiak, Kathryn L. Shultz, Kerri N. Smith, Sarah J. Halfyard, Wesley G. Beamer   +5 more
core   +1 more source