Results 71 to 80 of about 7,684 (200)

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Sex determination [PDF]

, 2012
Multicellular animals are a diverse lot, with widely varied body plans and lifestyles. One feature they share, however, is a nearly universal reliance on sexual reproduction for species propagation.
Gamble, Tony
core   +1 more source

Circulating levels of TNF-related apoptosis inducing-ligand are decreased in patients with large adult-type granulosa cell tumors-implications for therapeutic potential [PDF]

, 2016
Targeted treatments are needed for advanced adult-type granulosa cell tumors (AGCTs). We set out to assess tumor tissue and circulating levels of TNF-related apoptosis-inducing ligand (TRAIL), a promising anti-cancer cytokine, in patients affected by ...
Farkkila, Anniina, Haltia, Ulla-Maija, Heikinheimo, Markku, Pihlajoki, Marjut, Secchiero, Paola, Unkila-Kallio, Leila, Zauli, Giorgio   +6 more
core   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

A 46,XY female DSD patient with bilateral gonadoblastoma, a novel SRY missense mutation combined with a WT1 KTS splice-site mutation [PDF]

, 2012
Patients with Disorders of Sex Development (DSD), especially those with gonadal dysgenesis and hypovirilization are at risk of developing malignant type II germ cell tumors/cancer (GCC) (seminoma/dysgerminoma and nonseminoma), with either carcinoma in ...
Alders, M. (Mariëlle), Bernard, P. (Pascal), Boer, S. (Suzan) de, Brüggenwirth, H.T. (Hennie), Drop, S.L.S. (Stenvert), Harley, V.R. (Vincent), Hersmus, R. (Remko), Looijenga, L.H.J. (Leendert), McElreavy, K. (Kenneth), Oosterhuis, J.W. (Wolter), Sreenivasan, R. (Rajini), Stoop, J.A. (Hans), White, S.J. (Stefan), Wolffenbuttel, K.P. (Katja), Zwan, Y.G. (Yvonne ) van der   +14 more
core   +1 more source

Sperm Sexing in Selected Animals and Humans: Methods, Applications, and Future Prospects

Andrology, EarlyView.
ABSTRACT Background Sperm sexing is a technique that enables the selection of offspring sex by sorting spermatozoa based on their sex chromosomes. This technology has gained increasing attention due to its potential applications in both animal breeding and human‐assisted reproduction.
Domrazek Kinga, Jurka Piotr
wiley   +1 more source

Profiles of mRNA Expression of FOXL2, P450arom, DMRT1, AMH, P450c17, SF1, ERα and AR, in Relation to Gonadal Sex Differentiation in Duck Embryo

The Journal of Poultry Science, 2008
The present study was conducted to show a profile of mRNA expression of sex-differentiation related genes in the duck gonad. Fertile duck eggs (Cherry-valley) were incubated (hatching at day 28 of incubation) and the gonads were collected at days 7, 8 ...
Naomi Koba, Toshimichi Ohfuji, Yonju Ha, Shusei Mizushima, Akira Tsukada, Noboru Saito, Kiyoshi Shimada   +6 more
doaj   +1 more source

Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation. [PDF]

PLoS ONE, 2017
BACKGROUND:Adult-type granulosa cell tumors of the ovary (aGCTs) are rare tumors that represent 2-5% of ovarian malignancies. The prognosis of this tumor is favorable, and it is characterized by slow progression.
Satoshi Yanagida, Michael S Anglesio, Tayyebeh M Nazeran, Amy Lum, Momoko Inoue, Yasushi Iida, Hirokuni Takano, Takashi Nikaido, Aikou Okamoto, David G Huntsman   +9 more
doaj   +1 more source

Sexual Development of the Hermaphroditic Scallop Argopecten irradians Revealed by Morphological, Endocrine and Molecular Analysis

Frontiers in Cell and Developmental Biology, 2021
Simultaneous or functional hermaphrodites possessing both ovary and testis at the same time are good materials for studying sexual development. However, previous research on sex determination and differentiation was mainly conducted in gonochoristic ...
Huilan Wei, Wanru Li, Tian Liu, Yajuan Li, Liangjie Liu, Ya Shu, Lijing Zhang, Shi Wang, Shi Wang, Shi Wang, Qiang Xing, Qiang Xing, Lingling Zhang, Lingling Zhang, Zhenmin Bao, Zhenmin Bao, Zhenmin Bao   +16 more
doaj   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source