Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. [PDF]
PLoS ONE, 2014 In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene ...
Chung Hyun Park +4 more
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FoxO1 as a tissue-specific therapeutic target for type 2 diabetes
Frontiers in Endocrinology, 2023 Forkhead box O (FoxO) proteins are transcription factors that mediate many aspects of physiology and thus have been targeted as therapeutics for several diseases including metabolic disorders such as type 2 diabetes mellitus (T2D).
Nicole A. Teaney +2 more
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Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1 [PDF]
Diabetes, 2018 Premenopausal women exhibit enhanced insulin sensitivity and reduced incidence of type 2 diabetes (T2D) compared with age-matched men, but this advantage disappears after menopause with disrupted glucose homeostasis, in part owing to a reduction in ...
Hui Yan +16 more
openalex +2 more sources
Studies of Foxo1 over the Past 25 Years: Mechanisms of Insulin Resistance and Glucose Dysregulation [PDF]
CellsForkhead box protein O1 (Foxo1) is an insulin-suppressed transcription factor that governs multiple biological processes, including cell proliferation, apoptosis, autophagy, mitochondrial function, and energy metabolism. Over the past 25 years, Foxo1 has
Wanbao Yang +3 more
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Effect of Combined Exercises on Glucose Homeostasis and Plasma Levels of Sirtuin 1 and FOXO1 in Obese Elderly Men [PDF]
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī YazdIntroduction: Aging and obesity have common symptoms, including glucose and lipid metabolism changes. Activation of sirtuin 1 and FOXO1 (Forkhead Box Protein O1) can positively affect metabolic disorders associated with aging and obesity.
Maryam Safari +2 more
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MicroRNA21/HDAC4 mediates podocyte apoptosis under high glucose conditions by regulating the activation of FoxO1 [PDF]
Scientific ReportsDiabetic kidney disease (DKD), which lacks effective treatment, has become the leading cause of end-stage renal disease. Apoptosis of podocytes, as a vital mode of cell injury, plays an important role in the progression of DKD.
Lanjun Fu +6 more
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Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1 [PDF]
Journal of Medical Biochemistry, 2023 Background: To explore the biological effects of CASC11 on aggravating diabetic nephropathy (DN) by regulating FoxO1 (forkhead transcription factor O1). Methods: Serum levels of CASC11 and FoxO1 in DN patients were detected.
Zhang Yun +6 more
doaj +1 more source
The effect of metformin along with high-intensity interval training on gene expression of FoxO1 and Atrogin-1 in type 2 diabetic mice [PDF]
Journal of Shahrekord University of Medical Sciences, 2023 Background and aims: Muscle atrophy is a complication of type 2 diabetes, in which the expression of atrophy-related genes is increased. The present study aimed to investigate the effect of high-intensity interval training (HIIT) and metformin on gene ...
Atefeh Rahimi +2 more
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Research, 2023 Triple-negative breast cancer (TNBC) is considered as the most hazardous subtype of breast cancer owing to its accelerated progression, enormous metastatic potential, and refractoriness to standard treatments.
Yuhui Tang +11 more
semanticscholar +1 more source
Advancement of science, 2023 The biological roles of epithelial–mesenchymal transition (EMT) in the pathogenesis of radiation‐induced lung injury (RILI) have been widely demonstrated, but the mechanisms involved have been incompletely elucidated.
Yang Feng +10 more
semanticscholar +1 more source