Results 1 to 10 of about 70,533 (185)

FoxO1 as a tissue-specific therapeutic target for type 2 diabetes

Frontiers in Endocrinology, 2023
Forkhead box O (FoxO) proteins are transcription factors that mediate many aspects of physiology and thus have been targeted as therapeutics for several diseases including metabolic disorders such as type 2 diabetes mellitus (T2D).
Nicole A. Teaney, Nicole E. Cyr, Nicole E. Cyr   +2 more
doaj   +2 more sources

Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. [PDF]

PLoS ONE, 2014
In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene ...
Chung Hyun Park, Danalea V Skarra, Alissa J Rivera, David J Arriola, Varykina G Thackray   +4 more
doaj   +18 more sources

Studies of Foxo1 over the Past 25 Years: Mechanisms of Insulin Resistance and Glucose Dysregulation [PDF]

Cells
Forkhead box protein O1 (Foxo1) is an insulin-suppressed transcription factor that governs multiple biological processes, including cell proliferation, apoptosis, autophagy, mitochondrial function, and energy metabolism. Over the past 25 years, Foxo1 has
Wanbao Yang, Jeffrey Guo, Jianxun Song, Shaodong Guo   +3 more
doaj   +2 more sources

MicroRNA21/HDAC4 mediates podocyte apoptosis under high glucose conditions by regulating the activation of FoxO1 [PDF]

Scientific Reports
Diabetic kidney disease (DKD), which lacks effective treatment, has become the leading cause of end-stage renal disease. Apoptosis of podocytes, as a vital mode of cell injury, plays an important role in the progression of DKD.
Lanjun Fu, Nan Yang, Juan Jin, Hongbo Chen, Junfen Fan, Qiang He, Qingqing Ye   +6 more
doaj   +2 more sources

Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1 [PDF]

Journal of Medical Biochemistry, 2023
Background: To explore the biological effects of CASC11 on aggravating diabetic nephropathy (DN) by regulating FoxO1 (forkhead transcription factor O1). Methods: Serum levels of CASC11 and FoxO1 in DN patients were detected.
Zhang Yun, Shi Shuhan, Lin Changda, Che Lishuang, Li Yuangen, Zeng Quanzuan, Lin Weiyuan   +6 more
doaj   +1 more source

The effect of metformin along with high-intensity interval training on gene expression of FoxO1 and Atrogin-1 in type 2 diabetic mice [PDF]

Journal of Shahrekord University of Medical Sciences, 2023
Background and aims: Muscle atrophy is a complication of type 2 diabetes, in which the expression of atrophy-related genes is increased. The present study aimed to investigate the effect of high-intensity interval training (HIIT) and metformin on gene ...
Atefeh Rahimi, Maryam Delfan, Seed Daneshyar   +2 more
doaj   +1 more source

Dissection of FOXO1-Induced LYPLAL1-DT Impeding Triple-Negative Breast Cancer Progression via Mediating hnRNPK/β-Catenin Complex

Research, 2023
Triple-negative breast cancer (TNBC) is considered as the most hazardous subtype of breast cancer owing to its accelerated progression, enormous metastatic potential, and refractoriness to standard treatments.
Yuhui Tang, Wenwen Tian, Shaoquan Zheng, Yutian Zou, Jindong Xie, Junsheng Zhang, Xing Li, Yuying Sun, Jing Lan, Ning Li, Xiaoming Xie, Hailin Tang   +11 more
semanticscholar   +1 more source

MicroRNA-486-5p suppresses inflammatory response by targeting FOXO1 in MSU-treated macrophages

Autoimmunity, 2022
Gouty arthritis (GA) is mainly caused by the precipitation of monosodium urate (MSU) crystals in the joint. Recently, different regulatory roles of microRNAs (miRNAs) in arthritis have been widely verified. Nevertheless, the specific function of microRNA-
Jianguo Hu, Cheng Jin, Li Fang, Yao Lu, Yanying Wu, Xiangfeng Xu, Simei Sun   +6 more
doaj   +1 more source

METTL3 Mediates Epithelial–Mesenchymal Transition by Modulating FOXO1 mRNA N6‐Methyladenosine‐Dependent YTHDF2 Binding: A Novel Mechanism of Radiation‐Induced Lung Injury

Advancement of science, 2023
The biological roles of epithelial–mesenchymal transition (EMT) in the pathogenesis of radiation‐induced lung injury (RILI) have been widely demonstrated, but the mechanisms involved have been incompletely elucidated.
Yang Feng, P. Yuan, Hongjuan Guo, Liming Gu, Zhao Yang, Jian Wang, Wei Zhu, Qi Zhang, Jianping Cao, Li-li Wang, Yang Jiao   +10 more
semanticscholar   +1 more source

Low-dose LPS alleviates early brain injury after SAH by modulating microglial M1/M2 polarization via USP19/FOXO1/IL-10/IL-10R1 signaling

Redox Biology, 2023
Background Low-dose lipopolysaccharide (LPS) protects against early brain injury (EBI) after subarachnoid hemorrhage (SAH). However, the mechanism underlying the neuroprotective roles of low-dose LPS remain largely undefined. Methods A SAH mice model was
Weihua Tao, Guibo Zhang, Chengyuan Liu, Lide Jin, Xuehua Li, Shuaifeng Yang   +5 more
semanticscholar   +1 more source