Results 31 to 40 of about 74,948 (336)
European Journal of Breast Health, 2022 Objective:Breast cancer (BC) is the most prevalent female cancer globally and this is also true in Iranian women. Alteration in circulating microRNAs affects the fate of immune cells, affecting immunological response to neoplasia.Materials and Methods:We
Farhad Seif +6 more
doaj +1 more source
Foxo1 in hepatic lipid metabolism [PDF]
Cell Cycle, 2010 This division of labor is thought to contribute to the hypergly-cemia (inhibition of IRS2 signaling) and the paradoxical lipid accumulation (sus-tained IRS1 signaling) in type 2 diabetes. Regardless, recent work with genetically modified mice shows that both IRS1 and IRS2 are strong inhibitors of FoxO1,
Zhiyong, Cheng, Morris F, White
openaire +2 more sources
Role of LncRNA H19 in promoting endometrial deciduation
陆军军医大学学报, 2023 Objective To explore the effect of LncRNA H19 on endometrial decidualization. Methods The expression of LncRNA H19 in decidual tissues of spontaneous abortion and induced abortion was detected by RT-qPCR; The expression of LncRNA H19 in non-pregnant ...
WANG Tingting +4 more
doaj +1 more source
The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]
, 2019 Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi +12 more
core +1 more source
FoxO1 and hepatic lipid metabolism [PDF]
Current Opinion in Lipidology, 2009 PURPOSE OF REVIEW: This review summarizes recent research implicating Forkhead box (Fox)O1, a key transcription factor in glucose metabolism, in the regulation of hepatic lipid metabolism. Insulin dysregulation leading to hypertriglyceridemia is associated with increased hepatic VLDL secretion.
Janet D, Sparks, Henry H, Dong
openaire +2 more sources
Obesity Facts, 2020 Objective: To investigate the anorexigenic and anti-obesity effectiveness of electroacupuncture (EA) on high-fat-diet-induced (HFDI) obese rats with insulin resistance (IR) and to reveal the possible mechanisms of EA affecting SIRT1 (silent mating type ...
Qing Shu +7 more
doaj +1 more source
Effect of miR-581 on Autophagy of Ovarian Cancer SKOV3 Cells by Regulating FOXO1
Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the effect and mechanism of miR-581 on the autophagy of ovarian cancer SKOV3 cells. Methods miR-581 mimics and miR-581 NC were transfected into SKOV3 cells, and the transfection efficiency was detected by qRT-PCR.
GAO Haining +4 more
doaj +1 more source
Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]
, 2015 Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise +7 more
core +1 more source
Nuclear FoxO1 inflames insulin resistance [PDF]
The EMBO Journal, 2010 FoxO1 regulates the transcription of genes involved in diabetes, cancer and ageing. In this issue of The EMBO Journal, Olefsky and colleagues report that FoxO1 also causes inflammation by regulating the pro-inflammatory Tlr4 signalling pathway in macrophages.
John E, Dominy, Pere, Puigserver
openaire +2 more sources
ESF-EMBO symposium "molecular biology and innovative therapies in sarcomas of childhood and adolescence" Sept 29–Oct 4, Polonia Castle Pultusk, Poland [PDF]
, 2013 Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic ...
Fulda, Simone +3 more
core +2 more sources