Results 51 to 60 of about 74,948 (336)
Analysis of Foxo1‐regulated genes using Foxo1‐deficient pancreatic β cells [PDF]
Genes to Cells, 2012 Several reports have suggested that Foxo1, a key regulator in differentiation, growth and metabolism, is involved in pancreatic β‐cell function. However, detailed analyses have been hampered by a lack of Foxo1‐deficient β cells. To elucidate Foxo1's function in β cells, we produced a β‐cell line with inducible Foxo1 deletion. We generated a conditional
Satsuki, Miyazaki +6 more
openaire +2 more sources
Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]
, 2015 Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng +5 more
core +7 more sources
Renal Failure, 2019 Objective: To detect the combination protective effect of bone marrow mesenchymal stem cells (BMSCs) and Klotho gene on the renal ischemia-reperfusion injury (RIRI). Methods: BMSCs isolated from rats were transfected with Klotho gene to form BMSCKl.
Li-Bo Xie +5 more
doaj +1 more source
The progestin receptor interactome in the female mouse hypothalamus: Interactions with synaptic proteins are isoform specific and ligand dependent [PDF]
, 2017 Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study,
Acharya, Kalpana D +12 more
core +3 more sources
Journal of Cellular and Molecular Medicine, 2022 Autophagy is designated as a biological recycling process to maintain cellular homeostasis by the sequestration of damaged proteins and organelles in plasma and cargo delivery to lysosomes for degradation and reclamation. This organelle recycling process
Jiaji Yue +5 more
semanticscholar +1 more source
MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation [PDF]
Clinical and Molecular HepatologyBackground/Aims Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and abnormal MET expression plays a crucial role in its progression. However, the specific pathogenic mechanisms of MET in HCC have yet to be fully elucidated.
Tiantian Wang +11 more
doaj +1 more source
Journal of Advanced Research, 2021 Introduction: The proliferation of vascular smooth muscle cells (VSMCs) is an important physiological and pathological basis for many cardiovascular diseases.
Xiaoyu Tian +12 more
doaj +1 more source
FOXO1 modulates osteoblast differentiation
Bone, 2011 Forkhead box O1 (FOXO1) is upregulated during bone formation and in response to stimulation by bone morphogenetic proteins. Studies presented here examined the functional role of FOXO1 in a well defined culture system in which pre-osteoblastic cells undergo terminal differentiation in vitro. Mineralizing cultures of MC3T3-E1 cells were examined with or
Siqueira, Michelle F +8 more
openaire +4 more sources
Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons [PDF]
, 2008 Activation of cyclin-dependent kinase 1 (Cdk1) has been linked to cell death of postmitotic neurons in brain development and disease. We found that Cdk1 phosphorylated the transcription factor FOXO1 at Ser249 in vitro and in vivo.
BECKER, Esther B.E. +7 more
core +1 more source
Expression of FOXO1 in Liver Cancer and Its Prognostic Significance: An Analysis Based on TCGA
Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the expression and prognostic value of FOXO1 gene in liver cancer tissues based on TCGA and HPA databases. Methods The RNA-seq data of FOXO1 gene in liver cancer were downloaded from TCGA.
YANG Tingfang, WANG Li, ZHANG Yong
doaj +1 more source