Results 161 to 170 of about 171,978 (359)
Developmental regulation of Foxp3 expression during ontogeny [PDF]
, 2005 Jason D. Fontenot +3 more
openalex +1 more source
Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis. [PDF]
, 2019 BACKGROUND: Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE).
Chai, Zhi +12 more
core +1 more source
Advanced Science, EarlyView.Natural killer cells, central to anti‐tumor defense, undergo unexpected reprogramming within the tumor microenvironment. Instead of producing IFN‐γ and TNF‐α, they elevate amphiregulin, a tumor‐promoting factor. This shift is linked to glucocorticoid receptor activity and prostaglandin signaling.
Qin Wei +8 more
wiley +1 more source
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells [PDF]
, 2005 Manuela Battaglia +2 more
openalex +1 more source
An Engineered Probiotic Consortium Based on Quorum‐Sensing for Colorectal Cancer Immunotherapy
Advanced Science, EarlyView.This work develops an engineered probiotic consortium sensing pH, hypoxia, and lactate in the tumor microenvironment. It releases a lactate‐depleting enzyme (LdhA) and a PD‐L1 nanobody. In humanized mouse models (MC38 and HT‐29 tumors), it achieves durable oscillations, suppresses tumors, activates CD8+, CD4+, IFN‐γ+ T cells, and reduces Foxp3 ...
Yufei Guo +11 more
wiley +1 more source
Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease [PDF]
, 2005 Emmanuel Zorn +10 more
openalex +1 more source
Emerging Nanozyme Strategies for Precision Breast Cancer Treatment
Advanced Science, EarlyView.Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang +6 more
wiley +1 more source
Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3 [PDF]
, 2005 Giuseppe Penna +6 more
openalex +1 more source
Advanced Science, EarlyView.MARCO+ TAMs dominate restrained cytotoxicity of CD8+ CTLs and ICB resistance in RCC. Mechanically, MARCO impairs MHC‐I‐mediated neoantigen cross‐presentation via the SOCS1‐JAK1‐STAT1‐NLRC5 signaling cascade in TAMs. Targeted MARCO treatment boosts macrophage antigen cross‐presentation and empowers CD8+ T cells, thereby potentiating ICB efficacy ...
Jiayuan Chen +14 more
wiley +1 more source
Медицинская иммунология, 2019 Introduction. Diagnosis of kidney cancer presents significant difficulties, since symptoms of the disease may appear only at an advanced stage. Increasing attention is paid to the search for markers that allow for rapid and effective tumor diagnosis and ...
Z. V. Amoev +6 more
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