Results 141 to 150 of about 134,443 (312)

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

FoxP3+ cells: Location.

, 2014
FoxP3+ cells: Location.
Cecilia Hermans (653654), Thomas Kirchner (109827), Doris Mayr (443795), Jutta Engel (612905), Stefan Endres (384040), David Anz (653655)   +5 more
core   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Association of FoxP3⁺ T regulatory lymphocytes with epicardial adipose tissue thickness in patients with coronary heart disease

Acta Biomedica Scientifica
Background. Increase ofthe epicardial adipose tissue (EAT) thickness isassociated with development of inflammation and cardiovascular complications, however, there is no data on the relationship between EAT thickening and the number of immunosuppressive ...
I. V. Kologrivova, O. A. Kharitonova, A. A. Dmitriukov, E. S. Kravchenko, O. A. Koshelskaya, T. E. Suslova   +5 more
doaj   +1 more source

Image_2_Characterizing Foxp3+ and Foxp3- T cells in the homeostatic state and after allo-activation: resting CD4+Foxp3+ Tregs have molecular characteristics of activated T cells.jpeg

Due to the intracellular expression of Foxp3 it is impossible to purify viable Foxp3+ cells on the basis of Foxp3 staining. Consequently CD4+Foxp3+ regulatory T cells (Tregs) in mice have mostly been characterized using CD4+CD25+ T cells or GFP-Foxp3 ...
Natalie M. Niessen (17844470), Zilei Liu (1357500), Katherine J. Baines (10984584), David Clark (738), Munish K. Heer (17844473), G. Alexander Bishop (17844476), Paul R. Trevillian (17844479)   +6 more
core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Table_1_Characterizing Foxp3+ and Foxp3- T cells in the homeostatic state and after allo-activation: resting CD4+Foxp3+ Tregs have molecular characteristics of activated T cells.xlsx

Due to the intracellular expression of Foxp3 it is impossible to purify viable Foxp3+ cells on the basis of Foxp3 staining. Consequently CD4+Foxp3+ regulatory T cells (Tregs) in mice have mostly been characterized using CD4+CD25+ T cells or GFP-Foxp3 ...
Natalie M. Niessen (17844470), Zilei Liu (1357500), Katherine J. Baines (10984584), David Clark (738), Munish K. Heer (17844473), G. Alexander Bishop (17844476), Paul R. Trevillian (17844479)   +6 more
core   +1 more source

Phenotype and functional analysis of Foxp3^hi and Foxp3^int T cells in direct co-cultures or separated through a transwell.

, 2013
T cells from direct or transwell-separated iRBC co-cultures were harvested on day 6 of culture and either re-stimulated with PMA/ionomycin for intracellular cytokine staining, or phenotyped directly.
Brian M. Cooke (245105), Stephen J. Rogerson (34036), Magdalena Plebanski (21001), Anja Scholzen (90403), Diana Mittag (371113)   +4 more
core   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source

Association between FOXP3 expression and DFS stratified according to FOXP3-positive region, ER status, sample size, study design, geographic region and the FOXP3-positive cut-off value.

, 2015
DFS, disease-free survival; ER, estrogen receptor; HR, hazard ratio; CI, confidence interval; I2, I-squared.Association between FOXP3 expression and DFS stratified according to FOXP3-positive region, ER status, sample size, study design, geographic ...
Da Liu Min (787226), Shu Chen Lin (787224), Yang Yao (280888), Zhi Hua Gan (787225)   +3 more
core   +1 more source