Results 131 to 140 of about 134,443 (312)

FoxP3 and IDO in Canine Melanocytic Tumors

, 2019
Human melanoma is one of the deadliest forms of cancer, with poor prognosis and high resistance to chemotherapy and radiotherapy. The discovery of immunosuppressive mechanisms in the human melanoma microenvironment led to the use of new prognostic ...
Iussich, Selina, Menchetti, Laura, Silvestri, Serenella, Brachelente, Chiara, Mechelli, Luca, Porcellato, Ilaria, DE PAOLIS, LIVIA, Vichi, Gaia, Sforna, Monica   +8 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Epigenetic regulation of FOXP3 gene expression in relation to impaired function of regulatory T cells in systemic lupus erythematosus

Exploration of Immunology
The impaired function of regulatory T (Treg) cells and the imbalance of Treg/Th17 cells play a central role in developing autoimmune diseases such as systemic lupus erythematosus (SLE).
Parnian Fakour, Ata Shirizadeh, Ahmad Tahamoli-Roudsari, Ghasem Solgi   +3 more
doaj   +1 more source

Circulating Tumour Cells and FOXP3 in Regulatory T-Cells as New Modalities in Cancer Diagnosis and Metastasis Location Prediction

Acta Medica Indonesiana, 2023
Cancer is a complex group of diseases which arises from uncontrolled growth and spread of abnormal cells in the body. The pathophysiology of cancer involves a sequence of events at the cellular and molecular levels, often initiated by genetic mutations ...
Ikhwan Rinaldi
doaj  

Most tumor-infiltrating FoxP3⁺ cells retain FoxP3 expression in vivo.

, 2013
FoxP3-GFP-Cre×Rosa-tdTomato mice were implanted with B16 cells to form tumors. Expression of GFP on tdTomato+ cells was examined by flow cytometry. GFP+ tdTomato+ T cells are current FoxP3+ T cells, whereas GFP− tdTomato+ T cells are ex-FoxP3+ T cells ...
Jee H. Lee (334618), Chang H. Kim (204892), Chuanwu Wang (334616)   +2 more
core   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity

Cancer Management and Research, 2020
Yaling Li,1– 3 Junjie Li,1 Juanjuan Dong,1 Lei Zhang,2 Dongling Liu,1,4 Jianzheng He,1– 3 Yali She,2 Chengxu Ma,2 Yongqi Liu1– 3 1Provincial-Level Key Laboratory of Molecular Medicine of Major Diseases and Study on Prevention and ...
Li Y, Li J, Dong J, Zhang L, Liu D, He J, She Y, Ma C, Liu Y   +8 more
doaj  

The Foxp3^+→− T_REG cell phenotype is stable and correlates with a methylated Foxp3 promoter.

, 2013
TCRβ−/− mice received CD4+GFP+ T cells (0.5×106) from Ly5.1+ congenic Foxp3GFP reporter mice. Ly5.1+CD4+GFP+ (Foxp3+) or GFP− (Foxp3−) cells were sorted from lymphoid tissues of recipient mice 14 days post transfer.
Martin Olivier (54338), Ciriaco A. Piccirillo (159498), Maria Da Silva Martins (325486), Tony C. Huang (325485), Ekaterina Yurchenko (325484), Moshe Szyf (228712), Megan K. Levings (325487), Marina T. Shio (239781)   +7 more
core   +1 more source

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

Advanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu, Shiying Guo, Leilei Lv, Guiqin Fan, Yu Shen, Qiuxia Qu, Cheng Chen   +6 more
wiley   +1 more source

DataSheet_1_Characterizing Foxp3+ and Foxp3- T cells in the homeostatic state and after allo-activation: resting CD4+Foxp3+ Tregs have molecular characteristics of activated T cells.docx

Due to the intracellular expression of Foxp3 it is impossible to purify viable Foxp3+ cells on the basis of Foxp3 staining. Consequently CD4+Foxp3+ regulatory T cells (Tregs) in mice have mostly been characterized using CD4+CD25+ T cells or GFP-Foxp3 ...
Natalie M. Niessen (17844470), Zilei Liu (1357500), Katherine J. Baines (10984584), David Clark (738), Munish K. Heer (17844473), G. Alexander Bishop (17844476), Paul R. Trevillian (17844479)   +6 more
core   +1 more source