Results 151 to 160 of about 134,443 (312)

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Image_1_Characterizing Foxp3+ and Foxp3- T cells in the homeostatic state and after allo-activation: resting CD4+Foxp3+ Tregs have molecular characteristics of activated T cells.jpeg

Due to the intracellular expression of Foxp3 it is impossible to purify viable Foxp3+ cells on the basis of Foxp3 staining. Consequently CD4+Foxp3+ regulatory T cells (Tregs) in mice have mostly been characterized using CD4+CD25+ T cells or GFP-Foxp3 ...
Natalie M. Niessen (17844470), Zilei Liu (1357500), Katherine J. Baines (10984584), David Clark (738), Munish K. Heer (17844473), G. Alexander Bishop (17844476), Paul R. Trevillian (17844479)   +6 more
core   +1 more source

FOXP3 expression and OS.

, 2015
FOXP3 expression and OS.
Da Liu Min (787226), Shu Chen Lin (787224), Yang Yao (280888), Zhi Hua Gan (787225)   +3 more
core   +1 more source

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

Table_2_Characterizing Foxp3+ and Foxp3- T cells in the homeostatic state and after allo-activation: resting CD4+Foxp3+ Tregs have molecular characteristics of activated T cells.xlsx

Due to the intracellular expression of Foxp3 it is impossible to purify viable Foxp3+ cells on the basis of Foxp3 staining. Consequently CD4+Foxp3+ regulatory T cells (Tregs) in mice have mostly been characterized using CD4+CD25+ T cells or GFP-Foxp3 ...
Natalie M. Niessen (17844470), Zilei Liu (1357500), Katherine J. Baines (10984584), David Clark (738), Munish K. Heer (17844473), G. Alexander Bishop (17844476), Paul R. Trevillian (17844479)   +6 more
core   +1 more source

Inhibition of eIF4E activity results in spontaneous induction of Foxp3 expression in activated T_Foxp3− cells.

, 2013
TFoxp3− cells were IL-2/TCR-activated for 72 h in the presence of increasing concentrations of 4ei-1 or the control pro-drug 4ei-4 in undifferentiating conditions, and Foxp3 expression (i.e. GFP) was assessed by flow cytometry. (a) Representative density
Valentina Gandin (296404), Shui Li (409322), Ivan Topisirovic (409321), Ciriaco A. Piccirillo (159498), Ola Larsson (15776), Nahum Sonenberg (68692), Ekaterina Yurchenko (325484), Eva Bjur (409320), Lei Zheng (106363), Carston R. Wagner (214741)   +9 more
core   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

Mutational dissection of ProR of Foxp3 reveals distinct transcriptional programs.

, 2015
(A) A representation of the Foxp3 mutants’ effects on the expression of target genes measured by flow cytometry. Each box maps the region that has been deleted/replaced by stretches of alanines with the fill in color denoting the effect on the examined ...
Xin Xie (311744), Kristian G. Andersen (225212), Alexander G. Betz (69342), Jesper K. Nissen (760010), Daniel Hebenstreit (760011), Sarah A. Teichmann (14212), Michael J. T. Stubbington (760009)   +6 more
core   +1 more source

Peripheral Expression of FOXP3 in Brazilian Patients with IPEX Syndrome: From FOXP3 Biomarker to Targeted FOXP3 Therapy Within the CNE3I

Journal of Human Immunity
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder caused by loss-of-function mutations in the FOXP3 gene, which is critical for the development of functional regulatory T cells (Tregs). In IPEX patients, Tregs are unable to inhibit effector T cell proliferation and cytokine production, leading to a ...
Leonardo Oliveira Mendonça, Amanda Melato de Oliveira, Sandra Maria Monteiro, Maria Lúcia Carnevale Marin, Danielli Bichuetti-Silva, Ana Luiza Cunha, Paula Lyra, Renata Capeletti Padula, Luma Abou Jokh Espindola, Giovanna Capato Vilero, Joseane Chiabai, Cristina Kokron, Márcia Toraiwa Iwashita, Ludmilla Masiero, Mayra Dorna, Isabella Faria-Morais, Guilherme Burgarelli, Jessie Lee An Alexander, Rosa Bachetta, Samar Freschi-Barros, Jorge Kalil, Magda Maria Carneiro-Sampaio   +21 more
openaire   +1 more source