Results 161 to 170 of about 129,408 (207)

Tumor-infiltrating immune cell types predicting recurrence-free survival in melanoma patients receiving adjuvant PD-1 inhibitor therapy. [PDF]

Front Immunol
Ladányi A, Fröhlich G, Hegyi B, Horváth P, Balatoni T.   +4 more
europepmc   +1 more source

SRSF3 determines T_reg cell fate in antitumor immunity and autoimmunity. [PDF]

Sci Adv
Jia R, Guo J, Yan L, Lin C, Jia J, Shao J, Zhang D, Liu N, Chen W.   +8 more
europepmc   +1 more source

A novel CAF population coordinates hyper-suppressive regulatory T cell recruitment and localization in lung cancer. [PDF]

Nat Immunol
Ringham OR, Rivera M, Loffredo LF, Ozsoy MA, Healy CM, Cheng MF, Jin Y, Chen N, de Los Santos-Alexis K, Azizi E, Saqi A, Buechler MB, Concepcion-Crisol CP, Arpaia N.   +13 more
europepmc   +1 more source

Generation of T cell containing adipose tissue organoids. [PDF]

iScience
Kühne C, Majlesain Y, Subramanyam SH, Neullens CT, Lahrtz C, Ruhl T, Beier J, Bennstein SB, Rink L, Tenbrock K, Weighardt H, Ohl K.   +11 more
europepmc   +1 more source

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Polymorphism of the ovine FOXP3 gene (FOXP3)

Veterinary Immunology and Immunopathology, 2011
FOXP3 is a transcription factor predominantly expressed in CD4(+) CD25(+) thymocytes and CD4(+) CD25(+) peripheral T cells. It has been reported that variation in the FOXP3 gene (FOXP3) could cause impaired immune regulation. Using PCR-SSCP, variation in exon 4, exon 9-10 and exon 13-14 of ovine FOXP3, covering three functional domains (a proline rich ...
Guo, Yang, Huitong, Zhou, Jon G H, Hickford   +2 more
openaire   +2 more sources

FoxP3 partners up

Nature Immunology, 2017
By switching its partners, FoxP3 segregates into functional and non-functional transcriptional complexes.
David Bending, Masahiro Ono
openaire   +2 more sources

Functional Analysis of FOXP3

Annals of the New York Academy of Sciences, 2008
Tolerance to self antigens is established in two ways: first in the thymus through the deletion of thymocytes expressing self‐reactive T cell receptors; and second, in the periphery through multiple mechanisms involving deletion, anergy, and suppression.
Jane H, Buckner, Steven F, Ziegler
openaire   +2 more sources

Advances in Foxp3+ regulatory T cells (Foxp3+ Treg) and key factors in digestive malignancies [PDF]

Frontiers in Immunology
Foxp3+ regulatory T cells (Foxp3+ Treg) play a role in regulating various types of tumors, but uncertainty still exists regarding the exact mechanism underlying Foxp3+ Treg activation in gastrointestinal malignancies.
Qiu-Hong Wang
exaly   +2 more sources

Human FOXP3 and tumour microenvironment

Immunology, 2022
AbstractThe tumour microenvironment (TME) is a complex system composed of cancer cells, stromal cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance of tumours and suppress antitumor immune responses. Transcription factor forkhead box protein 3 (FOXP3) is the main marker of Tregs, which dominates the function of ...
Jia Wang, Ruining Gong, Chenyang Zhao, Ke Lei, Xiaoyuan Sun, He Ren   +5 more
openaire   +2 more sources

FOXP3: Of Mice and Men

Annual Review of Immunology, 2006
The immune system has evolved mechanisms to recognize and eliminate threats, as well as to protect against self-destruction. Tolerance to self-antigens is generated through two fundamental mechanisms: (a) elimination of self-reactive cells in the thymus during selection and (b) generation of a variety of peripheral regulatory cells to control self ...
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