Results 111 to 120 of about 134,443 (312)

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

REGULATORY T CELLS IN CHILDREN WITH ALLERGY

Медицинская иммунология, 2014
. Percentage of CD4+CD25hi is increased in children with allergy, and it is independent on their nosology, severity, sensitization and IgE level in blood. FOXP3 expression virtually was not altered. Inhalation of corticosteroids in asthma causes increase
A. Donetskova, N. Sharova, M. Litvina, O. Burmenskaya, D. Trofimov, M. Yartsev, L. Alexeev, A. Yarilin   +7 more
doaj   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

CD25+CD134+ CD39+FoxP3+ cells have bona fide Tregs phenotype.

, 2018
(A) Gating strategy used for detecting CMV-specific CD4+CD25+CD134+ CD39+FoxP3+ Tregs, and IFN-γ producing CD25+CD134+CD39-FoxP3- and CD25+CD134+ CD39-FoxP3+. PBMCs from CMV+ individuals were stimulated with CMV lysate for 44hrs.
Yves Levy (119516), Jean-Daniel Lelièvre (3173220), Vedran Brezar (337452), Nabila Seddiki (214661), Christine Lacabaratz (567696), Lylia Hani (4249249), Mathieu Surenaud (78141), Audrey Hubert (4249252)   +7 more
core   +1 more source

Conjunctival FOXP3 expression in trachoma: do regulatory T cells have a role in human ocular Chlamydia trachomatis infection? [PDF]

, 2006
BACKGROUND: Trachoma, caused by ocular infection with Chlamydia trachomatis, remains the leading infectious cause of blindness and in 2002 was responsible for 3.6% of total global blindness.
Faal Nkoyo, Jeffries, David, Sarr Isatou, Joof Hassan, Nkoyo Faal, David Jeffries, Laye Mass, Martin J Holland, Robin L Bailey, Bailey Robin L, Bailey, Robin L, Holland, Martin J, Jeffries David, Joof, Hassan, Laye, Mass, Holland Martin J, Hassan Joof, Mass Laye, Mabey David C. W, Sarr, Isatou, David C W Mabey, Faal, Nkoyo, Isatou Sarr, Mabey, David CW   +23 more
core   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

使用FLAG标签肽及慢病毒载体共同筛选小鼠foxp3基因RNA干扰的有效靶点

Zhongshan Daxue xuebao. Yixue kexue ban, 2007
【目的】筛选高效的foxp3 RNA干扰的靶点用于阻断CD4^＋CD25^＋ Treg细胞的免疫抑制功能。【方法】使用oligoengine软件设计foxp3基因shRNA序列，化学合成法合成4条shRNA序列，构建含foxp3的靶序列的慢病毒载体：构建出表达FLAG融合蛋白和目的基因的工具细胞293T细胞用于筛选RNA干扰的有效靶点。【结果】成功包装了4条foxp3基因靶序列相应的慢病毒颗粒；成功构建了表达融合蛋白和目的基因的293T工具细胞：在工具细胞上筛选出了2条RNAi效率分别为91.3％和95．
史艳侠, 韩文杰, 彭柔君, 张景航, 黄慧强, 姜文奇   +5 more
doaj  

Table_6_Characterizing Foxp3+ and Foxp3- T cells in the homeostatic state and after allo-activation: resting CD4+Foxp3+ Tregs have molecular characteristics of activated T cells.xlsx

Due to the intracellular expression of Foxp3 it is impossible to purify viable Foxp3+ cells on the basis of Foxp3 staining. Consequently CD4+Foxp3+ regulatory T cells (Tregs) in mice have mostly been characterized using CD4+CD25+ T cells or GFP-Foxp3 ...
Natalie M. Niessen (17844470), Zilei Liu (1357500), Katherine J. Baines (10984584), David Clark (738), Munish K. Heer (17844473), G. Alexander Bishop (17844476), Paul R. Trevillian (17844479)   +6 more
core   +1 more source

Phenotyping of FOXP3⁺ Tregs.

, 2016
A) Gating strategy for accurate determination of the proportion of regulatory T cells in PBMCs 1. Lymphocytes; 2. CD4+ T cells; 3. CD4+CD45RA+FOXP3low T cells; 4. CD4+CD45RA-FOXP3low T cells; 5.CD4+CD45RA-FOXP3high T cells); B) Percentage of blood CD45RA-
Jun Li (6494), Xunya Hou (842959), Odette Mariani (470823), Hongbin He (312136), Xavier Sastre (340023), Mathieu Sertorio (842960), Hélia Dessein (3213444), Alain Dessein (191161), Anne-Marie Dombey (842967), Pablo Oliveira (842962), Martine Chavanieu (842966), Xinsong Luo (842965), Audrey Romano (437176), Sandrine Oyegue (842963), Yuesheng Li (219117), Sandrine Cabantous (842961), Violaine Arnaud (842964)   +16 more
core   +1 more source