Results 111 to 120 of about 168,700 (307)

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

HDAC inhibition potentiates immunotherapy in triple negative breast cancer. [PDF]

, 2017
Triple-negative breast cancer (TNBC) represents a more aggressive and difficult subtype of breast cancer where responses to chemotherapy occur, but toxicity is significant and resistance often follows. Immunotherapy has shown promising results in various
Ali, Niwa, Budillon, Alfredo, Krings, Gregor, Munster, Pamela N, Park, Jeenah, Pawlowska, Nela, Rosenblum, Michael D, Terranova-Barberio, Manuela, Thomas, Scott   +8 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA

Медицинская иммунология, 2016
Forty-two patients with allergic bronchial asthma (ABA) forty persons with non-allergic bronchial asthma (NABA), and 47 healthy controls were involved into the study. Expression of FoxP3 mRNA was analyzed by RT-PCR. In patients with bronchial asthma (ABA
A. V. Eremeeva, L. N. Sorokina, V. N. Mineev, V. V. Lim, M. A. Nyoma, V. I. Trofimov   +5 more
doaj   +1 more source

Downregulation of Ezh2 methyltransferase by FOXP3: New insight of FOXP3 into chromatin remodeling?

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013
Transcription factor FOXP3 (forkhead box P3) is found initially as a key regulator in regulatory T cells. Recently its expression has been demonstrated in some non-lymphoid normal and cancerous cells. Now FOXP3 has been proven to regulate cancer-related genes, especially suppressor genes in breast cancer.
Shen, Zhu, Chen, Ling, Yang, Xiaojun, Zhao, Yun, Pier, Eric, Zhang, Xia, Yang, Xichuan, Xiong, Ya   +7 more
openaire   +2 more sources

IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

, 2012
It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the temporal and tissue-specific cellular sources of IFN-γ during P.
Blount, Daniel G, Couper, Kevin N, de Souza, J Brian, Greig, Rachel, Gwyer Findlay, Emily, Hafalla, Julius CR, Hunter, Christopher A, Riley, Eleanor M, Shaw, Tovah N, Stumhofer, Jason S, Villegas-Mendez, Ana   +10 more
core   +1 more source

Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]

, 2016
Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo, CARONNA, Roberto, CHIRLETTI, Piero, CIARDI, Antonio, DEL BENE, GABRIELLA, FARELLI, FRANCESCO, Focaccetti, Chiara, Longo, Flavia, MORELLI, Sergio, PACELLA, ILENIA, PICONESE, SILVIA, SACCO, LUCA, SCHINZARI, VALERIA, TIMPERI, ELEONORA, VESTRI, Anna Rita   +14 more
core   +1 more source

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

Perbedaan Ekspresi Foxp3+ dan Cd8+ Tumor Infiltrating Lymphocytes Karsinoma Payudara pada Berbagai Stadium T

Indonesian Journal of Cancer, 2018
Background: Breast carcinoma, the most common malignancy in women, are often accompanied by tumor infiltrating lymphocytes (TIL) which has controversial clinical relevance. TIL is thought to reflect the host’s immune response to malignant tumors.
Anisia Indiralia, Alphania Rahniayu, Sjahjenny Mustokoweni   +2 more
doaj   +1 more source