Results 91 to 100 of about 129,408 (207)
REGULATORY T CELLS IN CHILDREN WITH ALLERGY
Медицинская иммунология, 2014 . Percentage of CD4+CD25hi is increased in children with allergy, and it is independent on their nosology, severity, sensitization and IgE level in blood. FOXP3 expression virtually was not altered. Inhalation of corticosteroids in asthma causes increase
A. Donetskova +7 more
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Kickstarting Foxp3 with c-Rel [PDF]
Immunity, 2009 In this issue of Immunity, reports by Long et al. (2009) and Ruan et al. (2009) suggest that the transcription factor NF-kappaB-c-Rel is an important molecular mechanism by which T cell receptor-specificity for self-antigens instructs the selection of Foxp3(+) regulatory T cells.
openaire +2 more sources
使用FLAG标签肽及慢病毒载体共同筛选小鼠foxp3基因RNA干扰的有效靶点
Zhongshan Daxue xuebao. Yixue kexue ban, 2007 【目的】筛选高效的foxp3 RNA干扰的靶点用于阻断CD4^＋CD25^＋ Treg细胞的免疫抑制功能。【方法】使用oligoengine软件设计foxp3基因shRNA序列，化学合成法合成4条shRNA序列，构建含foxp3的靶序列的慢病毒载体：构建出表达FLAG融合蛋白和目的基因的工具细胞293T细胞用于筛选RNA干扰的有效靶点。【结果】成功包装了4条foxp3基因靶序列相应的慢病毒颗粒；成功构建了表达融合蛋白和目的基因的293T工具细胞：在工具细胞上筛选出了2条RNAi效率分别为91.3％和95．
史艳侠 +5 more
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Association of two FOXP3 polymorphisms with breast cancer susceptibility in Chinese Han women
, 2018 Tian Tian,1,* Meng Wang,1,* Yi Zheng,1,* Tielin Yang,2 Wenge Zhu,3 Hongtao Li,4 Shuai Lin,1 Kang Liu,1 Peng Xu,1 Yujiao Deng,1 Linghui Zhou,1 Zhijun Dai1 1Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’
Wang M +11 more
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A tumour suppressor role for FOXP3 and FOXP3-regulated microRNAs in breast cancer cells. [PDF]
, 2013 During their lifetime, 1 in 9 Australian women will be diagnosed with breast cancer, a disease that arises due to mutations and epigenetic modifications to tumour suppressor genes and cancer-promoting oncogenes.
McInnes, Natasha Jacqueline
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Comparison of the nuclear translocation abilities of WT Foxp3 and Foxp3 mutants.
, 2013 A. Schematic diagram showing the approximate locations of the zinc-finger (ZF), leucine-zipper (LZ) and the forkhead domain (FHD) in the full-length WT mouse Foxp3. Vertical arrows indicate sites of proteolytic cleavage.
Wayne W. Hancock (44791) +1 more
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Canonical miRNAs stabilize FoxP3 expression.
, 2013 Flow cytometric analysis of FoxP3 stability in lymphocytes isolated from FoxP3-GFP-hCre:DGCR8wt/lox (het) and FoxP3-GFP-hCre:DGCR8lox/lox (KO) mice. (a) Representative FACS histograms of FoxP3 intracellular staining of CD4+GFP− Tconv and CD4+GFP+ Treg ...
Lukas T. Jeker (163456) +3 more
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The molecular mechanisms of Foxp3 gene regulation.
, 2011 Induction of Foxp3 gene expression and acquisition of regulatory T cell fate is, understandably, a highly controlled process and one which many investigators want to illuminate.
Konkel, Joanne E; id_orcid +7 more
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Exploration of ImmunologyThe impaired function of regulatory T (Treg) cells and the imbalance of Treg/Th17 cells play a central role in developing autoimmune diseases such as systemic lupus erythematosus (SLE).
Parnian Fakour +3 more
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Acta Medica Indonesiana, 2023 Cancer is a complex group of diseases which arises from uncontrolled growth and spread of abnormal cells in the body. The pathophysiology of cancer involves a sequence of events at the cellular and molecular levels, often initiated by genetic mutations ...
Ikhwan Rinaldi
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