Results 81 to 90 of about 134,443 (312)

The gating strategies for identifying FOXP3+ Tregs (panel 8).

, 2019
For panel 8, the strategies of the first to fifth gates were the same as in panels 5 and 6 (Figs 4B and 5A). After gating on CD3+CD4+ T cells (G6), FOXP3 vs CD127 was used to assess the proportions of CD4+FOXP3- effector cells (G7), CD4+FOXP3+Tregs (G8 ...
Hsiao-Ting Chen (6725804), Negar Talaei Zanjani (6725813), Heather Burns (6725798), Suat Dervish (6725816), Yi Vee Chew (6725792), Ellis Patrick (4219258), Philip J. O’Connell (6725825), Xin Maggie Wang (6725819), Karen Keung (6725810), Wayne Hawthorne (6725822), Patricia Anderson (6725801), Lindy Williams (6725807), Elvira Jimenez Vera (6725789), Stephen Alexander (452429), Shounan Yi (510456), Min Hu (41912), Leigh Nicholson (6725795)   +16 more
core   +1 more source

Kickstarting Foxp3 with c-Rel [PDF]

Immunity, 2009
In this issue of Immunity, reports by Long et al. (2009) and Ruan et al. (2009) suggest that the transcription factor NF-kappaB-c-Rel is an important molecular mechanism by which T cell receptor-specificity for self-antigens instructs the selection of Foxp3(+) regulatory T cells.
openaire   +2 more sources

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Cytokine production by Foxp3- effector T cells.

, 2016
(a) The fraction of BAL CD4+ Foxp3- T cells that are Helios+ compared in smokers and non-smokers; and the fraction of BAL CD4+ Helios+ T cells that are Foxp3- compared in smokers and non-smokers (b) Comparison of IFNγ production between Foxp3-Helios+ and
Anders Eklund (177880), Johan Öckinger (150935), Anders Lindén (462052), Susanna Kullberg (3092739), Johan Grunewald (177876), Jan Wahlström (440880), Malin Müller (3308340), Mahyar Ostadkarampour (425762)   +7 more
core   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Effect of RUNX1/FOXP3 axis on apoptosis of T and B lymphocytes and immunosuppression in sepsis

Open Medicine, 2023
Lymphocyte apoptosis is a latent factor for immunosuppression in sepsis. Forkhead box protein P3 (FOXP3) can interact with RUNX family transcription factor 1 (RUNX1) in regulatory T cells.
Chao Yangfa, Huang Wenting, Xu Zhiheng, Li Ping, Gu Shaodong   +4 more
doaj   +1 more source

Lower number of peripheral FoxP3⁺ Treg cells in aged Tg4 FoxP3^gfp males.

, 2013
A. Frequency of FoxP3 expressing CD4+ T cells in the spleen of Tg4 FoxP3wt and Tg4 FoxP3gfp males aged 16–24 weeks (left) and the frequency of Helios and PD-1 expression gated on CD4+FoxP3+ splenocytes (middle and right).
Bronwen R. Burton (400298), Johan Verhagen (400297), Graham J. Britton (400299), Ella R. Shepard (400300), Stephen M. Anderton (297580), David C. Wraith (400301)   +5 more
core   +1 more source

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source