Results 61 to 70 of about 129,408 (207)
Foxo1 and Foxo3 help Foxp3 [PDF]
Immunity, 2010 In this issue of Immunity, Kerdiles et al. (2010) report that Foxo transcription factors are essential for the development and function of Foxp3-expressing regulatory T (Treg) cells via controlling the expression of genes associated with Treg cell function.
Ohkura, Naganari, Sakaguchi, Shimon
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The regulation of immune tolerance by FOXP3 [PDF]
Nature Reviews Immunology, 2017 The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes.
Ling, Lu, Joseph, Barbi, Fan, Pan
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Evaluation of FOXP3 and IL10 as immunosuppressant markers in pediatric acute lymphocytic leukemia patients in Iraq [PDF]
Romanian Journal of PediatricsBackground. Increased FOXP3+ Treg levels in the TME were positively correlated with a worse prognosis in certain cancer patients. FOXP3 was significantly overexpressed in pediatric B-ALL patients, and this overexpression was associated with a worse ...
Zainab Jasim Mohammed +3 more
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Archives of Medical Science, 2021 Introduction Patients with primary nephrotic syndrome (PNS) were reported to exhibit an evident imbalance between the number of Th17 and Treg cells in their peripheral blood monocytes (PBMCs), which might be the immunological basis of the disease ...
Li Jin +4 more
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Maintaining immunological tolerance with Foxp3 [PDF]
Cell Research, 2007 Central tolerance in the thymus is the primary mechanism for deleting autoreactive T cells. Despite this, escape of self-reactive T lymphocytes into the periphery reveals the threat of autoimmunity. To compensate for its imperfection, the thymus also produces a naturally occurring subset of Foxp3+ CD4+ CD25+ regulatory T cells with suppressive function,
Lauren E, Mays, Youhai H, Chen
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Association study of FOXP3 gene and the risk of 0020 pre-eclampsia
Clinical and Experimental Hypertension, 2018 Pre-eclampsia (PE) is a multifactorial pregnancy disorder, with serious consequences for both the mother and the fetus. Despite intense studies, the pathophysiology of PE remains enigmatic.
Milad Gholami +7 more
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FOXP3 and NFAT: Partners in Tolerance [PDF]
Cell, 2006 Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional ...
Rudensky, Alexander Y. +2 more
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Foxp3 mutants impair Foxp3 DNA binding ability.
, 2012 293T cells were transfected with EV, WT Foxp3, K17R or K18R without or with p300 expression vectors, and 48 h later, cell lysates were harvested. (A) Equal amounts of cell lysates were incubated with biotin-labeled Foxp3 binding site nucleotide, and ...
Ulf H. Beier (188290) +4 more
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Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky system
Biophysics and PhysicobiologyUnderstanding the temporal dynamics of T-cell transcription is crucial for insights into immune cell function and development. In this study, we show the features of the Timer-of-Cell-Kinetics-and-Activity (Tocky) system, which enables analysis of ...
Masahiro Ono
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Immunohistochemistry method and diagnostics of mycosis fungoides
Vestnik Dermatologii i Venerologii, 2017 Clinical patient examinations are not enough for diagnosing lymphoproliferative skin diseases now. Histological diagnostics is an important auxiliary method; however, it is not always applicable.
A. S. Zhukov +2 more
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