Results 61 to 70 of about 99,483 (169)

Immunohistochemistry method and diagnostics of mycosis fungoides

Vestnik Dermatologii i Venerologii, 2017
Clinical patient examinations are not enough for diagnosing lymphoproliferative skin diseases now. Histological diagnostics is an important auxiliary method; however, it is not always applicable.
A. S. Zhukov, I. E. Belousova, A. V. Samtsov   +2 more
doaj   +1 more source

Re-redefining Foxp3 function [PDF]

The Journal of Experimental Medicine, 2007
![Graphic][1] Foxp3 deletion in T cells (CD4-Cre) but not thymic epithelial cells (Foxn1-Cre) causes an autoimmune wasting disease. Liston et al. (page [475][2]) report that a transcription factor that protects mice against autoimmunity is required for regulatory T cell (T reg)
openaire   +1 more source

Transcription Factor Forkhead Box Protein 3 (FOXP3) as a Prognostic Indicator for Postoperative Outcomes in Patients with Breast Cancer: Establishment of a Prognostic Nomogram

Breast Cancer: Targets and Therapy
Chunlei Tan,1 Jinling Xu,2 Shiyuan Zhang,1 Shuqiang Liu,1 Xiaotian Yang,1 Danping Wu,1 Boqian Yu,1 Yuanxi Huang1 1Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, People’s Republic of China ...
Tan C, Xu J, Zhang S, Liu S, Yang X, Wu D, Yu B, Huang Y   +7 more
doaj  

OX40 costimulation turns off Foxp3+ Tregs

Blood, 2007
OX40 is a recently identified T-cell costimulatory molecule that belongs to the TNF/TNFR superfamily. OX40 can be expressed by both activated T effector cells and Foxp3+ Tregs. It is well known that OX40 delivers a potent costimulatory signal to T effector cells, but very little is known about the role of OX40 in regulating the suppressor properties of
Minh Diem, Vu, Xiang, Xiao, Wenda, Gao, Nicolas, Degauque, Ming, Chen, Alexander, Kroemer, Nigel, Killeen, Naoto, Ishii, Xian Chang, Li   +8 more
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使用FLAG标签肽及慢病毒载体共同筛选小鼠foxp3基因RNA干扰的有效靶点

Zhongshan Daxue xuebao. Yixue kexue ban, 2007
【目的】筛选高效的foxp3 RNA干扰的靶点用于阻断CD4^＋CD25^＋ Treg细胞的免疫抑制功能。【方法】使用oligoengine软件设计foxp3基因shRNA序列，化学合成法合成4条shRNA序列，构建含foxp3的靶序列的慢病毒载体：构建出表达FLAG融合蛋白和目的基因的工具细胞293T细胞用于筛选RNA干扰的有效靶点。【结果】成功包装了4条foxp3基因靶序列相应的慢病毒颗粒；成功构建了表达融合蛋白和目的基因的293T工具细胞：在工具细胞上筛选出了2条RNAi效率分别为91.3％和95．
史艳侠, 韩文杰, 彭柔君, 张景航, 黄慧强, 姜文奇   +5 more
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Transcription Factor Assay of Peripheral Blood T cells in Different Groups of Rheumatoid Arthritis Patients

Research in Molecular Medicine, 2020
Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and other tissues and organs of the body.
Saeid Taghiloo, Abolghasem Ajami, Mohsen Tehrani, Arezou Abbasi, Reza Alizadeh-Navaei, Mohsen Akhiani, Alireza Salami   +6 more
doaj  

Regulatory T-cells: The Face-off of the Immune Balance

Frontiers in Bioscience-Landmark
Regulatory T-cells (Tregs) play a crucial role in maintaining immune homeostasis, ensuring a balanced immune response. Tregs primarily operate in an antigen-specific fashion, facilitated by their distinct distribution within discrete niches.
Mahmoud Singer, Ahmed M. Elsayed, Mohamed I. Husseiny   +2 more
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ENTPD1, NT5E, ADORA2A, FOXP3 and RORγ gene expression in peripheral blood of patients with ulcerative colitis

Медицинская иммунология
Development of ulcerative colitis (UC) is accompanied by activation of the purinergic signaling pathway and an increased level of extracellular adenosine.
D. A. Atorin, G. A. Zhulai, L. V. Tophieva, I. V. Kurbatova, O. P. Dudanova   +4 more
doaj   +1 more source

New approach in Understanding Colorectal Cancer Immunosuppression and Immunotherapy-Based Strategies in the Treatment of Microsatellite Stable Colorectal Cancer

Acta Medica Bulgarica
Except the widely accepted use of immune Checkpoint inhibitors in the treatment of microsatellite instability-high (MSI-H) mismatch repair-deficient (MMRd) CRCs representing about 5% of all metastatic (m)CRC patients, new strategies are applied to cure ...
Gulubova M., Chonov D., Ignatova M. M., Yovchev Y.   +3 more
doaj   +1 more source

Unstable Foxp3 [PDF]

Nature Immunology, 2013
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