Results 51 to 60 of about 134,443 (312)

Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

OncoImmunology, 2019
Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells.
Tao Dao, Sung Soo Mun, Andrew C. Scott, Casey A. Jarvis, Tatyana Korontsvit, Zhiyuan Yang, Lianxing Liu, Martin G. Klatt, Manuel Guerreiro, Annamalai Selvakumar, Elliott J. Brea, Claire Oh, Cheng Liu, David A. Scheinberg   +13 more
doaj   +1 more source

Expression of the mRNA of the inflammatory component of the immune response in the period of the expected window of implantation in women with recurrent pregnancy loss in the programs of assisted reproductive technologies

Репродуктивная эндокринология, 2017
The aim of study. To reveal the peculiarities of mRNA expression of the inflammatory component genes of the immune response in the expected window of the implantation in women with RPL in ART programs. Material and methods.
К. П. Головатюк, В. Г. Дубініна, О. М. Носенко, Е. Т. Макшаєва, І. Л. Головатюк-Юзефпольська   +4 more
doaj   +1 more source

Value of Foxp3 expressing T-regulatory cells in renal tissue in lupus nephritis; an immunohistochemical study [PDF]

Journal of Nephropathology, 2016
Background: Forkhead box P3 (Foxp3) functions as a master regulator in the development and function of T-regulatory (Treg) cells. Recent studies have shown that autoimmune diseases including systemic lupus erythematosus (SLE) are associated with an ...
Marwa M Shakweer, Maha Behairy, Nadia G Elhefnawy, Tamer W Elsaid   +3 more
doaj   +1 more source

Maintaining immunological tolerance with Foxp3 [PDF]

Cell Research, 2007
Central tolerance in the thymus is the primary mechanism for deleting autoreactive T cells. Despite this, escape of self-reactive T lymphocytes into the periphery reveals the threat of autoimmunity. To compensate for its imperfection, the thymus also produces a naturally occurring subset of Foxp3+ CD4+ CD25+ regulatory T cells with suppressive function,
Lauren E, Mays, Youhai H, Chen
openaire   +2 more sources

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Foxp3

RCSB Protein Data Bank
Citation: 'Foxp3' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13141 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

The role of Foxp3 and Tbet co-expressing Treg cells in lung carcinoma

OncoImmunology, 2018
Despite the opposite roles of Tbet and Foxp3 in the immune system as well as in tumour biology, recent studies have demonstrated the presence of of CD4+ T cells, expressing both, Tbet and Foxp3.
Katerina Kachler, Corinna Holzinger, Denis I. Trufa, Horia Sirbu, Susetta Finotto   +4 more
doaj   +1 more source

Dysregulation of Foxp3-upregulated and Foxp3-downregulated genes by Foxp3 ProR subdomain mutations.

, 2015
P values were calculated with binomial tests to compare the distribution of Foxp3-upregulated and—downregulated genes with the distribution within all 2,407 Foxp3-regulated, TReg-relevant genes.Dysregulation of Foxp3-upregulated and Foxp3-downregulated ...
Xin Xie (311744), Kristian G. Andersen (225212), Alexander G. Betz (69342), Jesper K. Nissen (760010), Daniel Hebenstreit (760011), Sarah A. Teichmann (14212), Michael J. T. Stubbington (760009)   +6 more
core   +1 more source

Ex-Th17 Foxp3+ T cells - a novel subset of Foxp3+ T cells induced in cancer [PDF]

, 2015
Th17 and regulatory T (Treg) cells are integral in maintaining immune homeostasis and Th17-Treg misbalance associates with inflammation.\ud \ud We demonstrate that in addition to natural (n)Treg and induced (i)Treg cells developed from naïve precursors ...
Bartlett, David L, Stephanie Downs-Canner, David L Bartlett, Odunsi, Kunle, Kunle Odunsi, Natasa Obermajer, Ravindranathan, Roshni, Roshni Ravindranathan, Downs-Canner, Stephanie, Pawel Kalinski, Edwards, Robert P., Obermajer, Natasa, Kalinski, Pawel, Bartlett, David L., Edwards, Robert P, Robert P Edwards   +15 more
core   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source