Results 31 to 40 of about 134,443 (312)

Searching for the Achilles Heel of FOXP3 [PDF]

Frontiers in Oncology, 2013
FOXP3 is a multifaceted transcription factor with a major role in the control of immune homeostasis mediated by T regulatory cells (Treg). The immunoregulatory function of FOXP3 may hinder the induction of immune responses against cancer and infectious agents, and thus, development of inhibitors of its functions might give new therapeutic opportunities
Lozano, Teresa, Casares, Noelia, Lasarte, Juan José   +2 more
openaire   +3 more sources

GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice

Journal of Inflammation Research, 2021
Yifan Cai,1 Qiutang Zeng,1 Yuzhou Liu,2 Ruirui Zhu,1 Kunwu Yu,1 Wenbin Xu,1 Yue Wang,1 Yan Ding,1 Jian Yu,1 Chengliang Pan,1 Yudong Peng,1 Yi Mao,1 Peng Cheng,1 Lun Huang,1 Xiaobo Mao,1 Yucheng Zhong1 1Department of Cardiology, Union Hospital, Tongji ...
Cai Y, Zeng Q, Liu Y, Zhu R, Yu K, Xu W, Wang Y, Ding Y, Yu J, Pan C, Peng Y, Mao Y, Cheng P, Huang L, Mao X, Zhong Y   +15 more
doaj  

FOXP3-specific immunity [PDF]

OncoImmunology, 2013
Forkhead box P3 (FOXP3)-specific cytotoxic CD8+ T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3 and regulatory T cells, but also to kill FOXP3+ malignant T cells. The
openaire   +2 more sources

FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells [PDF]

Oncogene, 2011
The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target
McInnes, N., Sadlon, T., Brown, C., Pederson, S., Beyer, M., Schultze, J., McColl, S., Goodall, G., Barry, S.   +8 more
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Genetic polymorphism and allele frequency of the FOXP3 gene (rs2232365) in Iraqi patients with rheumatoid arthritis [PDF]

Romanian Journal of Rheumatology
Background. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, leading to joint destruction and disability.
Fatima Sami Hmoud, Manal Badi Salih
doaj   +1 more source

Association of FoxP3/Scurfin Germline Polymorphism (C-2383T/rs3761549) with Colorectal Cancer [PDF]

Iranian Journal of Colorectal Research, 2013
Background FoxP3 gene encodes a transcription factor with crucial roles in the development and function of regulatory T cells. Objectives The present study was conducted to investigate whether the C-2383T (rs3761549) polymorphism in the promoter ...
Zahra Mojtahedi, Nasrollah Erfani, Mohammad Reza Haghshenas, Seyed Vahid Hosseini, Abbas Ghaderi   +4 more
doaj   +1 more source

IPEX as a Result of Mutations in FOXP3 [PDF]

Clinical and Developmental Immunology, 2007
Immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare disorder caused by mutations in theFOXP3gene that result in the defective development ofCD4+CD25+regulatory T cells which constitute an important T cell subset involved in immune homeostasis and protection against autoimmunity.
Hans J. J. van der Vliet, Edward E. Nieuwenhuis   +1 more
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The correlation between rheumatoid factor and anti cyclic citrullinated peptides with gene expression of FoxP3 in rheumatoid artheritis patients [PDF]

International Journal of Biomedicine and Public Health, 2018
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affect 1-2% of people worldwide. Inflammation is an important factor in the pathogenesis of RA. Anti- Cyclic Citrullinated Peptid (Anti-CCP) antibody and Rheumatoid Factor (RF)
Nasrin Iranshahi, Seyed Mojtaba Amiri, Parisa Zafari, Mahdi Taghaddosi   +3 more
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IPEX Syndrome, FOXP3 and Cancer [PDF]

Journal of Syndromes, 2013
In this review, we introduce the IPEX syndrome and its relationship with germline mutations of the FOXP3 gene. We then describe the multiple functional roles of FOXP3 in regulatory T cells and epithelial cells as well as in IPEX syndrome and tumor progression.
Runhua, Liu, Silin, Li, Wei-Hsiung, Yang, Lizhong, Wang   +3 more
openaire   +2 more sources

NATURAL REGULATORY T CELLS AND THEIR MOLECULAR MARKER FOXP3 IN FREQUENTLY ILL PRE-SCHOOL CHILDREN LIVING IN AREAS WITH HUMAN-INDUCED IMPACT

Педиатрическая фармакология, 2013
The study presents the review of recent literature on microbial resistance in children suffered from reccurent respiratory infaction (RRI). Special aspects of immune system in children with allergy and acute respiratory infection are discussed. We report
A. D. Pertseva, N. Z. Zokirov, V. V. Troshina, L. S. Namazova-Baranova, S. Y. Tarakanova   +4 more
doaj   +1 more source