Results 31 to 40 of about 99,561 (267)

CD₈⁺ AND CD₄⁺ REGULATORY T CELLS IN COLORECTAL CANCER

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2020
The pathogenesis of colorectal cancer (CRC) is closely associated with the development of an antitumor immune response. An important role in the regulation of the immune response is given to regulatory T cells (Treg), which may interfere with the ...
Galina Zhulai, Anastasia Novitskaya, Alexei Churov, Alexander Romanov, Kylymbek Mamashov, Anastasia Tonkushina   +5 more
doaj   +1 more source

Anti-regulatory T cell vaccines in immunotherapy: focusing on FoxP3 as target

Human Vaccines & Immunotherapeutics, 2019
Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment.
Neda Mousavi-Niri, Maryam Naseroleslami, Jamshid Hadjati   +2 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Runx proteins regulate Foxp3 expression [PDF]

Journal of Experimental Medicine, 2009
Runx proteins are essential for hematopoiesis and play an important role in T cell development by regulating key target genes, such as CD4 and CD8 as well as lymphokine genes, during the specialization of naive CD4 T cells into distinct T helper subsets.
Bruno, L, Mazzarella, L, Hoogenkamp, M, Hertweck, A, Cobb, BS, Sauer, S, Hadjur, S, Leleu, M, Naoe, Y, Telfer, JC, Bonifer, C, Taniuchi, I, Fisher, AG, Merkenschlager, M   +13 more
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

OncoImmunology, 2019
Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells.
Tao Dao, Sung Soo Mun, Andrew C. Scott, Casey A. Jarvis, Tatyana Korontsvit, Zhiyuan Yang, Lianxing Liu, Martin G. Klatt, Manuel Guerreiro, Annamalai Selvakumar, Elliott J. Brea, Claire Oh, Cheng Liu, David A. Scheinberg   +13 more
doaj   +1 more source

Expression of the mRNA of the inflammatory component of the immune response in the period of the expected window of implantation in women with recurrent pregnancy loss in the programs of assisted reproductive technologies

Репродуктивная эндокринология, 2017
The aim of study. To reveal the peculiarities of mRNA expression of the inflammatory component genes of the immune response in the expected window of the implantation in women with RPL in ART programs. Material and methods.
К. П. Головатюк, В. Г. Дубініна, О. М. Носенко, Е. Т. Макшаєва, І. Л. Головатюк-Юзефпольська   +4 more
doaj   +1 more source

The role of transcription factor FoxP3 as a predictor of acute and chronic urticaria in children

Медицинский вестник Юга России, 2021
Objective: To study the transcription factor FoxP3 in children with acute and chronic spontaneous urticaria as a possible predictor of the severity and chronicity of urticaria.Materials and Methods: A total of 264 children of both sexes aged from 6 to 16
S. V. Maltsev, L. P. Sizyakina, A. A. Lebedenko   +2 more
doaj   +1 more source

Foxo1 and Foxo3 help Foxp3 [PDF]

Immunity, 2010
In this issue of Immunity, Kerdiles et al. (2010) report that Foxo transcription factors are essential for the development and function of Foxp3-expressing regulatory T (Treg) cells via controlling the expression of genes associated with Treg cell function.
Ohkura, Naganari, Sakaguchi, Shimon
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source