Results 31 to 40 of about 129,408 (207)

T regulatory lymphocytes and FoxP3 nuclear translocation in various adipose tissue depots in patients with coronary artery disease

Медицинская иммунология, 2023
T regulatory lymphocytes (Treg) are present is adipose tissue. Their frequency, as well as the level of FoxP3 nuclear translocation, in epicardial and thymus adipose tissue remains unexplored.
I. V. Kologrivova, A. A. Dmitriukov, O. A. Kharitonova, E. S. Kravchenko, N. V. Naryzhnaya, O. A. Koshelskaya, T. E. Suslova   +6 more
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The role of FOXP3 in autoimmunity

Current Opinion in Immunology, 2016
FOXP3 controls the development and function of T regulatory cells (Tregs). Autoimmunity is linked to changes in FOXP3 activity that can occur at multiple levels and lead to Treg dysfunction. For example, changes in IL-2 signaling, FOXP3 transcription and/or post-translational modifications can all contribute to loss of self-tolerance.
Pesenacker, AM, Cook, L, Levings, MK
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CD4CD25 Regulatory Cells Contribute to the Regulation of Colonic Th2 Granulomatous Pathology Caused by Schistosome Infection [PDF]

, 2011
Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down- modulated in size as the infection proceeds to chronicity.
Adrian P. Mountford, Aynsley, Sarah A, Sarah A. Aynsley, Cook, Peter C, Hogg, Karen G., Karen G. Hogg, Peter C. Cook, Mark C. Coles, Cook, Peter C; id_orcid, Peter C Cook, Cook Peter C., Cook, Peter C., Aynsley, Sarah A., Mountford Adrian P., Joseph D. Turner, Gavin R Jenkins, Aynsley Sarah A., Mountford, Adrian P, Paveley, Ross A., Ross A Paveley, Ross A. Paveley, Coles, Mark C, Turner, Joseph, Karen G Hogg, Hogg Karen G., Jenkins, Gavin R., Adrian P Mountford, Turner, Joseph D, Sarah A Aynsley, Paveley Ross A., Coles Mark C., Gavin R. Jenkins, Paveley, Ross A, Jenkins, Gavin R, Mark C Coles, Coles, Mark C., Hogg, Karen G, Joseph D Turner, Jenkins Gavin R., Mountford, Adrian P., Turner Joseph D.   +40 more
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Conjunctival FOXP3 expression in trachoma: do regulatory T cells have a role in human ocular Chlamydia trachomatis infection? [PDF]

, 2006
BACKGROUND: Trachoma, caused by ocular infection with Chlamydia trachomatis, remains the leading infectious cause of blindness and in 2002 was responsible for 3.6% of total global blindness.
Faal Nkoyo, Jeffries, David, Sarr Isatou, Joof Hassan, Nkoyo Faal, David Jeffries, Laye Mass, Martin J Holland, Robin L Bailey, Bailey Robin L, Bailey, Robin L, Holland, Martin J, Jeffries David, Joof, Hassan, Laye, Mass, Holland Martin J, Hassan Joof, Mass Laye, Mabey David C. W, Sarr, Isatou, David C W Mabey, Faal, Nkoyo, Isatou Sarr, Mabey, David CW   +23 more
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Expansion of Foxp3+ T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge [PDF]

, 2014
Research Funding Wellcome Trust, UK. Grant Numbers: 086827, 080088 NIH.
Maccallum, Donna M, Shohei Hori, Sarah L. Gaffen, Natasha Whibley, Herman Waldmann, Gow, Neil A R, Gaffen, SL, Gaffen, Sarah L, Hall, Andrew M, Sadia Zafreen, Whibley, N, Neil A. R. Gow, Hall, AM, Vickers, MA, Barker, Robert N, Hori, S, Robert N. Barker, Barker, RN, Andrew M. Hall, Waldmann, H, Mark A. Vickers, Gow, NA, Hori, Shohei, Donna M. Maccallum, Zafreen, Sadia, Maccallum, DM, Waldmann, Herman, Zafreen, S, Whibley, Natasha, Vickers, Mark A   +29 more
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FOXP3-specific immunity [PDF]

OncoImmunology, 2013
Forkhead box P3 (FOXP3)-specific cytotoxic CD8+ T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3 and regulatory T cells, but also to kill FOXP3+ malignant T cells. The
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IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]

, 2014
IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M., Katherine A. Smith, Maizels, Rick M, Rick M. Maizels, Smith, Katherine A., Smith, Katherine A   +5 more
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GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice

Journal of Inflammation Research, 2021
Yifan Cai,1 Qiutang Zeng,1 Yuzhou Liu,2 Ruirui Zhu,1 Kunwu Yu,1 Wenbin Xu,1 Yue Wang,1 Yan Ding,1 Jian Yu,1 Chengliang Pan,1 Yudong Peng,1 Yi Mao,1 Peng Cheng,1 Lun Huang,1 Xiaobo Mao,1 Yucheng Zhong1 1Department of Cardiology, Union Hospital, Tongji ...
Cai Y, Zeng Q, Liu Y, Zhu R, Yu K, Xu W, Wang Y, Ding Y, Yu J, Pan C, Peng Y, Mao Y, Cheng P, Huang L, Mao X, Zhong Y   +15 more
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Prostate cancer with different ERG status may show different FOXP3-positive cell numbers [PDF]

, 2016
Prostatic carcinoma is the most frequent cancer in males in the Western world. A significant proportion of these cancers have a recurrent translocation involving ETS family genes, which leads to the overexpression of ERG transcription factor.
Krystyna Gałązka, Mateusz Rubinkiewicz, Tomasz Gołąbek, Okoń, Krzysztof, Glajcar, Anna, Karolina Kaczmarczyk-Sekuła, Gałązka, Krystyna, Piotr Chłosta, Chłosta, Piotr, Kaczmarczyk-Sekuła, Karolina, Szpor, Joanna, Szopiński, Tomasz, Dyduch, Grzegorz, Krzysztof Okoń, Joanna Szpor, Gołąbek, Tomasz, Anna Glajcar, Grzegorz Dyduch, Katarzyna Miłek, Rubinkiewicz, Mateusz, Katarzyna Tyrak, Tyrak, Katarzyna, Miłek, Katarzyna, Tomasz Szopiński   +23 more
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Foxp3 and dominant tolerance [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2005
The hallmark of the adaptive immune system is the random generation of antigen receptors in developing lymphocyte clones through a process of somatic cell gene rearrangement mediated by the recombination-activating gene recombinase.
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