Results 21 to 30 of about 101,900 (265)
Searching for the Achilles Heel of FOXP3 [PDF]
Frontiers in Oncology, 2013 FOXP3 is a multifaceted transcription factor with a major role in the control of immune homeostasis mediated by T regulatory cells (Treg). The immunoregulatory function of FOXP3 may hinder the induction of immune responses against cancer and infectious agents, and thus, development of inhibitors of its functions might give new therapeutic opportunities
Lozano, Teresa +2 more
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The role of FOXP3 in autoimmunity
Current Opinion in Immunology, 2016 FOXP3 controls the development and function of T regulatory cells (Tregs). Autoimmunity is linked to changes in FOXP3 activity that can occur at multiple levels and lead to Treg dysfunction. For example, changes in IL-2 signaling, FOXP3 transcription and/or post-translational modifications can all contribute to loss of self-tolerance.
Pesenacker, AM, Cook, L, Levings, MK
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Foxp3 and dominant tolerance [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2005 The hallmark of the adaptive immune system is the random generation of antigen receptors in developing lymphocyte clones through a process of somatic cell gene rearrangement mediated by the recombination-activating gene recombinase.
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OncoImmunology, 2013 Forkhead box P3 (FOXP3)-specific cytotoxic CD8+ T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3 and regulatory T cells, but also to kill FOXP3+ malignant T cells. The
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GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice
Journal of Inflammation Research, 2021 Yifan Cai,1 Qiutang Zeng,1 Yuzhou Liu,2 Ruirui Zhu,1 Kunwu Yu,1 Wenbin Xu,1 Yue Wang,1 Yan Ding,1 Jian Yu,1 Chengliang Pan,1 Yudong Peng,1 Yi Mao,1 Peng Cheng,1 Lun Huang,1 Xiaobo Mao,1 Yucheng Zhong1 1Department of Cardiology, Union Hospital, Tongji ...
Cai Y +15 more
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A2 adenosine receptor contributes to the development of cow’s milk protein allergy via regulating regulatory T cells [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): A2 adenosine receptor (A2AR) is a novel promising target for the treatment of inflammatory and allergic diseases. However, its role in the development of cow’s milk protein allergy (CMPA) has not been elucidated.
Chuan-Ying Li +4 more
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Clinical Significance of FOXP3 Expression in BRCA1/2-Mutant Breast Cancer
Zhongliu Fangzhi YanjiuObjectiveTo investigate the potential significance of FOXP3 expression in BRCA1/2-mutant breast cancer. MethodsA total of 48 BRCA mutation carriers (16 with BRCA1 and 32 with BRCA2) and 78 age-matched non-carriers were included in this study ...
Linxi CHEN +6 more
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Association of FoxP3/Scurfin Germline Polymorphism (C-2383T/rs3761549) with Colorectal Cancer [PDF]
Iranian Journal of Colorectal Research, 2013 Background FoxP3 gene encodes a transcription factor with crucial roles in the development and function of regulatory T cells. Objectives The present study was conducted to investigate whether the C-2383T (rs3761549) polymorphism in the promoter ...
Zahra Mojtahedi +4 more
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IPEX as a Result of Mutations in FOXP3 [PDF]
Clinical and Developmental Immunology, 2007 Immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare disorder caused by mutations in theFOXP3gene that result in the defective development ofCD4+CD25+regulatory T cells which constitute an important T cell subset involved in immune homeostasis and protection against autoimmunity.
Hans J. J. van der Vliet +1 more
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IPEX Syndrome, FOXP3 and Cancer [PDF]
Journal of Syndromes, 2013 In this review, we introduce the IPEX syndrome and its relationship with germline mutations of the FOXP3 gene. We then describe the multiple functional roles of FOXP3 in regulatory T cells and epithelial cells as well as in IPEX syndrome and tumor progression.
Runhua, Liu +3 more
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