Results 21 to 30 of about 134,443 (312)

Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice. [PDF]

, 2007
Investigation of the role of regulatory T cells (Treg) in model systems is facilitated by their depletion using anti-CD25 Abs, but there has been considerable debate about the effectiveness of this strategy.
Couper, Kevin N, Riley, Eleanor M, Blount, Daniel G, Blount, Daniel G., Couper, Kevin N., De Souza, J. Brian, de Souza, J Brian, Suffia, Isabelle, Riley, Eleanor M., Belkaid, Yasmine   +9 more
core   +1 more source

ICOS controls Foxp3+ regulatory T-cell expansion, maintenance, and IL-10 production during helminth infection [PDF]

, 2012
Foxp3+ regulatory T (Treg) cells are key immune regulators during helminth infections, and identifying the mechanisms governing their induction is of principal importance for the design of treatments for helminth infections, allergies and autoimmunity ...
van der Werf, Nienke, MacDonald, Andrew, Redpath, Stephen A, Taylor, Matthew, Cervera, Ana M, Macdonald, Andrew S; id_orcid, Cervera, Ana, Taylor, Matthew D., Maizels, Rick M, Andrew S. MacDonald, Cervera, Ana M., Gray, David, Maizels, Rick, Stephen A. Redpath, Maizels, Rick M., Taylor, Matthew D, Macdonald, Andrew S.; id_orcid, Redpath, Stephen A., Matthew D. Taylor, Rick M. Maizels, David Gray, Nienke van der Werf, Ana M. Cervera   +22 more
core   +1 more source

Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance. [PDF]

, 2014
BACKGROUND: Colorectal cancer (CRC) progression is associated with suppression of host cell-mediated immunity and local immune escape mechanisms. Our aim was to assess the immune function in terms of expression of TNF, IFNG and FOXP3 in CRC. METHODS:
Kumar, D, S V Hodgson, D Kumar, Beggs, A D; id_orcid, S K Ganapathi, Hodgson, SV, Hodgson, S V, Ganapathi, SK, Beggs, AD, Ganapathi, S K, A D Beggs   +10 more
core   +1 more source

IL-10 from CD4(+)CD25(-)Foxp3(-)CD127(-) adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection [PDF]

, 2008
The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite replication, whilst failure to ...
Couper, Kevin N, Hafalla, Julius C, Riley, Eleanor M, Daniel G. Blount, Eleanor M Riley, Blount, Daniel G., Kevin N Couper, Richard A Flavell, Wilson, MS, de Souza, J Brian, Daniel G Blount, Mark S Wilson, Couper, KN, Blount, DG, Kamanaka, Masahito, Wilson, Mark S, Julius C. Hafalla, Belkaid, Yasmine, Masahito Kamanaka, Blount, Daniel G, Flavell, Richard A, Flavell, Richard A., J. Brian de Souza, Flavell, RA, De Souza, J. Brian, Kevin N. Couper, Kamanaka, M, Hafalla, Julius C., Julius C Hafalla, Eleanor M. Riley, Hafalla, JC, Riley, Eleanor M., Belkaid, Y, Yasmine Belkaid, De Souza, JB, Mark S. Wilson, Richard A. Flavell, Couper, Kevin N., Wilson, Mark S., Riley, EM, J Brian de Souza   +40 more
core   +2 more sources

CXCL4 promoted the production of CD4+CD25+FOXP3+treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway

Autoimmunity, 2020
Background: CXCL4 plays an essential role in the regulation of multiple immune diseases. However, the underlying role of CXCL4 is still not clear in sepsis. Aim: In the present study, we aimed to investigate the function of CXCL4 in sepsis.
Tao Xu, Jie Zhao, Xiaolin Wang, Yan Meng, Zhenzhen Zhao, Rui Bao, Xiaoming Deng, Jinjun Bian, Tao Yang   +8 more
doaj   +1 more source

Impact of breast milk miR-155 on the health of preterm neonates

Zdorovʹe Rebenka, 2022
Background. Breast milk (BM) is an important source of microRNAs (miRs). MicroRNAs are highly resistant to gastrointestinal enzymes and are well absorbed in the intestine. MiR-155 is one of the most expressed miR of BM.
O.E. Abaturov, A.O. Tovarnytska
doaj   +1 more source

T regulatory lymphocytes and FoxP3 nuclear translocation in various adipose tissue depots in patients with coronary artery disease

Медицинская иммунология, 2023
T regulatory lymphocytes (Treg) are present is adipose tissue. Their frequency, as well as the level of FoxP3 nuclear translocation, in epicardial and thymus adipose tissue remains unexplored.
I. V. Kologrivova, A. A. Dmitriukov, O. A. Kharitonova, E. S. Kravchenko, N. V. Naryzhnaya, O. A. Koshelskaya, T. E. Suslova   +6 more
doaj   +1 more source

CD4CD25 Regulatory Cells Contribute to the Regulation of Colonic Th2 Granulomatous Pathology Caused by Schistosome Infection [PDF]

, 2011
Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down- modulated in size as the infection proceeds to chronicity.
Adrian P. Mountford, Aynsley, Sarah A, Sarah A. Aynsley, Cook, Peter C, Hogg, Karen G., Karen G. Hogg, Peter C. Cook, Mark C. Coles, Cook, Peter C; id_orcid, Peter C Cook, Cook Peter C., Cook, Peter C., Aynsley, Sarah A., Mountford Adrian P., Joseph D. Turner, Gavin R Jenkins, Aynsley Sarah A., Mountford, Adrian P, Paveley, Ross A., Ross A Paveley, Ross A. Paveley, Coles, Mark C, Turner, Joseph, Karen G Hogg, Hogg Karen G., Jenkins, Gavin R., Adrian P Mountford, Turner, Joseph D, Sarah A Aynsley, Paveley Ross A., Coles Mark C., Gavin R. Jenkins, Paveley, Ross A, Jenkins, Gavin R, Mark C Coles, Coles, Mark C., Hogg, Karen G, Joseph D Turner, Jenkins Gavin R., Mountford, Adrian P., Turner Joseph D.   +40 more
core   +1 more source

The role of FOXP3 in autoimmunity

Current Opinion in Immunology, 2016
FOXP3 controls the development and function of T regulatory cells (Tregs). Autoimmunity is linked to changes in FOXP3 activity that can occur at multiple levels and lead to Treg dysfunction. For example, changes in IL-2 signaling, FOXP3 transcription and/or post-translational modifications can all contribute to loss of self-tolerance.
Pesenacker, AM, Cook, L, Levings, MK
openaire   +4 more sources

Foxp3 and dominant tolerance [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2005
The hallmark of the adaptive immune system is the random generation of antigen receptors in developing lymphocyte clones through a process of somatic cell gene rearrangement mediated by the recombination-activating gene recombinase.
openaire   +2 more sources