Foxp3: Shades of Tolerance [PDF]
Immunity, 2012 In this issue of Immunity, Darce et al. (2012) and Bettini et al. (2012) demonstrate that seemingly subtle alterations in the interaction of Foxp3 with its transcriptional partners have a ripple effect on the outcome of autoimmune phenotypes, worsening some while ameliorating others.
Chatila, Talal A., Williams, Calvin B.
openaire +2 more sources
Characterization of human epithelial resident memory regulatory T cells
Frontiers in Immunology, 2022 Human resident memory regulatory T cells (Tregs) exist in the normal, noninflamed skin. Except one, all previous studies analyzed skin Tregs using full-thickness human skin.
Takuya Sato +11 more
doaj +1 more source
FOXP3 expression in FOXP3+ tumor cells promotes hepatocellular cells metastasis [PDF]
Translational Cancer Research, 2020 Forkhead transcription factor 3 (FOXP3) is a key molecule for the development of regulatory T cell. Recent studies showed that FOXP3 was also expressed in tumor cells. This study is designed to identify the expression of FOXP3 and its pathogenesis in hepatocellular carcinoma (HCC).Through immunohistochemistry, RNA extraction and Real-Time Quantitative ...
Zhang, Henghui +9 more
openaire +2 more sources
T regulatory cells in cord blood--FOXP3 demethylation as reliable quantitative marker [PDF]
, 2010 Regulatory T-cells (Tregs), characterized as CD4+CD25(hi) T-cells expressing FOXP3, play a crucial role in controlling healthy immune development during early immune maturation. Recently, FOXP3 demethylation was suggested to be a novel marker for natural
Laura Layland +14 more
core +2 more sources
Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer [PDF]
, 2013 Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also
Kim, Mia +38 more
core +2 more sources
ICOS controls Foxp3+ regulatory T-cell expansion, maintenance, and IL-10 production during helminth infection [PDF]
, 2012 Foxp3+ regulatory T (Treg) cells are key immune regulators during helminth infections, and identifying the mechanisms governing their induction is of principal importance for the design of treatments for helminth infections, allergies and autoimmunity ...
van der Werf, Nienke +22 more
core +1 more source
Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice. [PDF]
, 2007 Investigation of the role of regulatory T cells (Treg) in model systems is facilitated by their depletion using anti-CD25 Abs, but there has been considerable debate about the effectiveness of this strategy.
Couper, Kevin N +9 more
core +1 more source
Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance. [PDF]
, 2014 BACKGROUND: Colorectal cancer (CRC) progression is associated with suppression of host cell-mediated immunity and local immune escape mechanisms. Our aim was to assess the immune function in terms of expression of TNF, IFNG and FOXP3 in CRC. METHODS:
Kumar, D +10 more
core +1 more source
IL-10 from CD4(+)CD25(-)Foxp3(-)CD127(-) adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection [PDF]
, 2008 The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite replication, whilst failure to ...
Couper, Kevin N +40 more
core +2 more sources
Autoimmunity, 2020 Background: CXCL4 plays an essential role in the regulation of multiple immune diseases. However, the underlying role of CXCL4 is still not clear in sepsis. Aim: In the present study, we aimed to investigate the function of CXCL4 in sepsis.
Tao Xu +8 more
doaj +1 more source