Results 11 to 20 of about 101,900 (265)

Prospective validation of CD4 CD25 FOXP3 T-regulatory cells as an immunological marker to differentiate intestinal tuberculosis from Crohn’s disease [PDF]

Intestinal Research, 2021
Background/Aims Crohn’s disease (CD) and intestinal tuberculosis (ITB) remain “difficult-to-differentiate” diseases. We have previously documented peripheral blood frequency of CD4+ CD25+ FOXP3+ T-regulatory cells (Treg) as a biomarker to differentiate ...
Ritika Rampal, Saurabh Kedia, Mohamad Nahidul Wari, Deepak Madhu, Amit Kumar Singh, Veena Tiwari, V. Pratap Mouli, Srikant Mohta, Govind Makharia, Vineet Ahuja   +9 more
doaj   +1 more source

Promiscuous Foxp3‐cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells [PDF]

Immunology & Cell Biology, 2014
Costimulatory signals by CD28 are critical for thymic regulatory T‐cell (Treg) development. To determine the functional relevance of CD28 for peripheral Treg post thymic selection, we crossed the widely used Forkhead box protein 3 (Foxp3)‐CreYFP mice to mice bearing a conditional Cd28 allele.
Franckaert, Dean, Dooley, James, Roos, Evelyne, Floess, Stefan, Huehn, Jochen, Luche, Herve, Fehling, Hans Joerg, Liston, Adrian, Linterman, Michelle A., Schlenner, Susan   +9 more
openaire   +3 more sources

The Role of Leukemia Inhibitory Factor in Counteracting the Immunopathology of Acute and Chronic Lung Inflammatory Diseases

Journal of Respiration, 2023
Leukemia inhibitory factor (LIF), a member of the IL-6 cytokine family, is highly expressed throughout the body in multiple tissues and cell types. LIF is primarily known to induce the differentiation of myeloid leukemia cells, but recent studies show ...
Howard Yu, Sahil Zaveri, Meshach Pillai, Harsha Taluru, Michael Schaible, Sahil Chaddha, Asad Ahmed, Said Tfaili, Patrick Geraghty   +8 more
doaj   +1 more source

FOXP3 Gene Variants in Patients with Systemic Lupus Erythematosus: Association with Disease Susceptibility in Men and Relationship with Abortion in Women [PDF]

Iranian Journal of Immunology, 2022
Background: FOXP3, an important transcription factor of regulatory T cells has shown a contribution to the development of various autoimmune diseases. Objectives: To investigate the influence of FOXP3 polymorphisms (rs3761548 and rs2294021) on systemic ...
Paria Heydarinezhad, Nasser Gholijani, Zahra Habibagahi, Mohammad Reza Malekmakan, Zahra Amirghofran   +4 more
doaj   +1 more source

Relationship between vitamin D plasma level and Foxp3 gene expression among rheumatoid arthritis patients

مجله علمی دانشگاه علوم پزشکی کردستان, 2018
Background and Aim: Rheumatoid arthritis (RA) is an autoimmune disease. It seems that the function of regulatory T cells (Tregs) is compromised in RA. Foxp3 is a critical transcription factor of these cells.
Zafari P, Mostafaei Sh, Iranshahi N, Jalili C, Taghadosi M   +4 more
doaj   +1 more source

Off-Target Deletion of Conditional Dbc1 Allele in the Foxp3^YFP-Cre Mouse Line under Specific Setting

Cells, 2019
The Cre-LoxP conditional knockout strategy has been used extensively to study gene function in a specific cell-type. In this study, the authors tried to engineer mice in which the Dbc1 gene is conditionally knocked out in Treg cells.
Chichu Xie, Fangming Zhu, Julie Wang, Weizhou Zhang, Joseph A. Bellanti, Bin Li, David Brand, Nancy Olsen, Song Guo Zheng   +8 more
doaj   +1 more source

Prediction of response to surgical therapy in nonsegmental vitiligo based on an immunohistochemical cutoff value

Journal of the Egyptian Women’s Dermatologic Society, 2020
Background Objective assessment of stability is still lacking in nonsegmental vitiligo (NSV). Objective To suggest immunohistochemical cutoff values that can predict a good response to surgical therapy of NSV cases.
Dalia A Bassiouny, Samar El Tahlawy, Amira El Tawdy, Mostafa Abdellatif, Doaa Ibrahim Eldesouky Amin   +4 more
doaj   +1 more source

Impact of breast milk miR-155 on the health of preterm neonates

Zdorovʹe Rebenka, 2022
Background. Breast milk (BM) is an important source of microRNAs (miRs). MicroRNAs are highly resistant to gastrointestinal enzymes and are well absorbed in the intestine. MiR-155 is one of the most expressed miR of BM.
O.E. Abaturov, A.O. Tovarnytska
doaj   +1 more source

CXCL4 promoted the production of CD4+CD25+FOXP3+treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway

Autoimmunity, 2020
Background: CXCL4 plays an essential role in the regulation of multiple immune diseases. However, the underlying role of CXCL4 is still not clear in sepsis. Aim: In the present study, we aimed to investigate the function of CXCL4 in sepsis.
Tao Xu, Jie Zhao, Xiaolin Wang, Yan Meng, Zhenzhen Zhao, Rui Bao, Xiaoming Deng, Jinjun Bian, Tao Yang   +8 more
doaj   +1 more source

T regulatory lymphocytes and FoxP3 nuclear translocation in various adipose tissue depots in patients with coronary artery disease

Медицинская иммунология, 2023
T regulatory lymphocytes (Treg) are present is adipose tissue. Their frequency, as well as the level of FoxP3 nuclear translocation, in epicardial and thymus adipose tissue remains unexplored.
I. V. Kologrivova, A. A. Dmitriukov, O. A. Kharitonova, E. S. Kravchenko, N. V. Naryzhnaya, O. A. Koshelskaya, T. E. Suslova   +6 more
doaj   +1 more source