Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells. [PDF]
Immunology & Cell Biology, 2015 Costimulatory signals by CD28 are critical for thymic regulatory T-cell (Treg) development. To determine the functional relevance of CD28 for peripheral Treg post thymic selection, we crossed the widely used Forkhead box protein 3 (Foxp3)-CreYFP mice to ...
Dooley, James +21 more
core +5 more sources
The Potential of FOXP3 in Predicting Survival and Treatment Response in Breast Cancer [PDF]
International Journal of General MedicineLuyao Liu,1 Wang Xiao,2 Chaojie Zhang,1 Peizhi Fan,1 Jie Zeng,1 Jianing Yi1 1Department of Breast and Thyroid Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, People’s Republic of China ...
Liu L +5 more
doaj +1 more source
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans [PDF]
FEBS Open BioIn vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Muller L +3 more
europepmc +2 more sources
FOXP3 expression in FOXP3+ tumor cells promotes hepatocellular cells metastasis [PDF]
Translational Cancer Research, 2020 Forkhead transcription factor 3 (FOXP3) is a key molecule for the development of regulatory T cell. Recent studies showed that FOXP3 was also expressed in tumor cells. This study is designed to identify the expression of FOXP3 and its pathogenesis in hepatocellular carcinoma (HCC).Through immunohistochemistry, RNA extraction and Real-Time Quantitative ...
Zhang, Henghui +9 more
openaire +2 more sources
Foxp3: Shades of Tolerance [PDF]
Immunity, 2012 In this issue of Immunity, Darce et al. (2012) and Bettini et al. (2012) demonstrate that seemingly subtle alterations in the interaction of Foxp3 with its transcriptional partners have a ripple effect on the outcome of autoimmune phenotypes, worsening some while ameliorating others.
Chatila, Talal A., Williams, Calvin B.
openaire +2 more sources
T regulatory cells in cord blood--FOXP3 demethylation as reliable quantitative marker [PDF]
, 2010 Regulatory T-cells (Tregs), characterized as CD4+CD25(hi) T-cells expressing FOXP3, play a crucial role in controlling healthy immune development during early immune maturation. Recently, FOXP3 demethylation was suggested to be a novel marker for natural
Laura Layland +14 more
core +2 more sources
Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer [PDF]
, 2013 Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also
Kim, Mia +38 more
core +2 more sources
Prospective validation of CD4 CD25 FOXP3 T-regulatory cells as an immunological marker to differentiate intestinal tuberculosis from Crohn’s disease [PDF]
Intestinal Research, 2021 Background/Aims Crohn’s disease (CD) and intestinal tuberculosis (ITB) remain “difficult-to-differentiate” diseases. We have previously documented peripheral blood frequency of CD4+ CD25+ FOXP3+ T-regulatory cells (Treg) as a biomarker to differentiate ...
Ritika Rampal +9 more
doaj +1 more source
Journal of the Egyptian Women’s Dermatologic Society, 2020 Background Objective assessment of stability is still lacking in nonsegmental vitiligo (NSV). Objective To suggest immunohistochemical cutoff values that can predict a good response to surgical therapy of NSV cases.
Dalia A Bassiouny +4 more
doaj +1 more source
FOXP3 Gene Variants in Patients with Systemic Lupus Erythematosus: Association with Disease Susceptibility in Men and Relationship with Abortion in Women [PDF]
Iranian Journal of Immunology, 2022 Background: FOXP3, an important transcription factor of regulatory T cells has shown a contribution to the development of various autoimmune diseases. Objectives: To investigate the influence of FOXP3 polymorphisms (rs3761548 and rs2294021) on systemic ...
Paria Heydarinezhad +4 more
doaj +1 more source