Results 11 to 20 of about 99,561 (267)
Off-Target Deletion of Conditional Dbc1 Allele in the Foxp3YFP-Cre Mouse Line under Specific Setting
Cells, 2019 The Cre-LoxP conditional knockout strategy has been used extensively to study gene function in a specific cell-type. In this study, the authors tried to engineer mice in which the Dbc1 gene is conditionally knocked out in Treg cells.
Chichu Xie +8 more
doaj +1 more source
Oncogene, 2010 FOXP3 is a transcription factor necessary and sufficient for induction of the immunosuppressive functions in regulatory T lymphocytes. Its expression was first considered as specific of this cell type, but FOXP3 can also be transiently expressed in T-cell antigen receptor-activated human nonregulatory T cells.
F, Martin +4 more
openaire +2 more sources
Journal of the Egyptian Women’s Dermatologic Society, 2020 Background Objective assessment of stability is still lacking in nonsegmental vitiligo (NSV). Objective To suggest immunohistochemical cutoff values that can predict a good response to surgical therapy of NSV cases.
Dalia A Bassiouny +4 more
doaj +1 more source
Promiscuous Foxp3‐cre activity reveals a differential requirement for CD28 in Foxp3+ and Foxp3− T cells [PDF]
Immunology & Cell Biology, 2014 Costimulatory signals by CD28 are critical for thymic regulatory T‐cell (Treg) development. To determine the functional relevance of CD28 for peripheral Treg post thymic selection, we crossed the widely used Forkhead box protein 3 (Foxp3)‐CreYFP mice to mice bearing a conditional Cd28 allele.
Franckaert, Dean +9 more
openaire +3 more sources
OncoImmunology, 2013 Forkhead box P3 (FOXP3)-specific cytotoxic CD8+ T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3 and regulatory T cells, but also to kill FOXP3+ malignant T cells. The
openaire +2 more sources
Impact of breast milk miR-155 on the health of preterm neonates
Zdorovʹe Rebenka, 2022 Background. Breast milk (BM) is an important source of microRNAs (miRs). MicroRNAs are highly resistant to gastrointestinal enzymes and are well absorbed in the intestine. MiR-155 is one of the most expressed miR of BM.
O.E. Abaturov, A.O. Tovarnytska
doaj +1 more source
FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells [PDF]
Oncogene, 2011 The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target
McInnes, N. +8 more
openaire +4 more sources
Autoimmunity, 2020 Background: CXCL4 plays an essential role in the regulation of multiple immune diseases. However, the underlying role of CXCL4 is still not clear in sepsis. Aim: In the present study, we aimed to investigate the function of CXCL4 in sepsis.
Tao Xu +8 more
doaj +1 more source
Медицинская иммунология, 2023 T regulatory lymphocytes (Treg) are present is adipose tissue. Their frequency, as well as the level of FoxP3 nuclear translocation, in epicardial and thymus adipose tissue remains unexplored.
I. V. Kologrivova +6 more
doaj +1 more source
Expression levels of MIF, NLRP1 and FOXP3 genes along with biomarker levels in patients with active form of non-segmental generalized vitiligo: A study in South Indian population [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2022 Vitiligo, the most widespread hypopigmentary syndrome, is considered to be a multifactorial disease in which the active melanocytes are lost. Vitiligo has been studied in a variety of ways, and several genes have been implicated.
Alokananda Chakraborty +10 more
doaj +1 more source