Results 11 to 20 of about 129,408 (207)
FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells [PDF]
Oncogene, 2011 The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target
Stephen Pederson +2 more
exaly +6 more sources
Oncogene, 2010 FOXP3 is a transcription factor necessary and sufficient for induction of the immunosuppressive functions in regulatory T lymphocytes. Its expression was first considered as specific of this cell type, but FOXP3 can also be transiently expressed in T-cell antigen receptor-activated human nonregulatory T cells.
Gregoire Mignot +2 more
exaly +3 more sources
Searching for the Achilles Heel of FOXP3 [PDF]
Frontiers in Oncology, 2013 FOXP3 is a multifaceted transcription factor with a major role in the control of immune homeostasis mediated by T regulatory cells (Treg). The immunoregulatory function of FOXP3 may hinder the induction of immune responses against cancer and infectious agents, and thus, development of inhibitors of its functions might give new therapeutic opportunities
Lozano, Teresa +2 more
openaire +5 more sources
Role of Epigenetic Modifications in The Aberrant Expression of The FOXP3 Gene in Endometriosis: A Case-Control Study [PDF]
International Journal of Fertility and SterilityBackground: Various studies have reported aberrant function of the immune system in endometriosis. This highlyprevalent disease can initiate and progress by numerous genetic and epigenetic alterations that affect immune systemfunctions.
Samaneh Chegeni +7 more
doaj +2 more sources
Downregulation of Ezh2 methyltransferase by FOXP3: New insight of FOXP3 into chromatin remodeling? [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013 Transcription factor FOXP3 (forkhead box P3) is found initially as a key regulator in regulatory T cells. Recently its expression has been demonstrated in some non-lymphoid normal and cancerous cells. Now FOXP3 has been proven to regulate cancer-related genes, especially suppressor genes in breast cancer.
Shen, Zhu +7 more
openaire +3 more sources
Regulatory T cells and Foxp3 [PDF]
Immunological Reviews, 2011 Summary: Regulatory T (Treg) cells play central role in regulation of immune responses to self‐antigens, allergens, and commensal microbiota as well as immune responses to infectious agents and tumors. Transcriptional factor Foxp3 serves as a lineage specification factor of Treg cells.
Alexander Rudensky
exaly +3 more sources
The Potential of FOXP3 in Predicting Survival and Treatment Response in Breast Cancer [PDF]
International Journal of General MedicineLuyao Liu,1 Wang Xiao,2 Chaojie Zhang,1 Peizhi Fan,1 Jie Zeng,1 Jianing Yi1 1Department of Breast and Thyroid Surgery, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, People’s Republic of China ...
Liu L +5 more
doaj +1 more source
Immunomodulatory Effect of Propolis on Foxp3 Gene Expression in Human Peripheral Blood Mononuclear Cells Stimulated in vitro with Pseudomonas Aeruginosa Ag [PDF]
Archives of Razi Institute, 2021 Immune balance during infection is critical for both supporting the defense of the immune system of the body and preventing an overly aggressive immune response.
F. A Alwaeely, K. N Madlum, M. A Alsaadi
doaj +1 more source
Upregulation of Cytotoxic T-Lymphocyte-Associated Protein 4 and Forkhead Box P3 Transcripts in Peripheral Blood of Patients with Bladder Cancer [PDF]
Iranian Journal of Medical Sciences, 2021 Background: Regulatory T cells (Tregs) play a key role in the progression of tumors. These cells express forkhead box P3 (FOXP3) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4), which are the potential targets for cancer immunotherapy.
Ali Ariafar +7 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2022 Autoimmune diseases are caused when immune cells act against self-protein. This biological self–non-self-discrimination phenomenon is controlled by a distinct group of lymphocytes known as regulatory T cells (Tregs), which are key inflammatory response ...
Tapas Kumar Goswami +9 more
doaj +1 more source