Results 41 to 50 of about 134,443 (312)

Natural T Regulatory Cells (n Treg) in the Peripheral Blood of Healthy Subjects and Subjects with Chronic Periodontitis – A Pilot Study [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: The T cells play a central role in the aetiopathogenesis of periodontal disease. Natural T regulatory cells (nTreg) are the key stone immunoregulatory elements having an anergic phenotype and play an important role in the suppression of
Ram Sabarish, Suresh Ranga Rao, Vamsi Lavu   +2 more
doaj   +1 more source

Foxo1 and Foxo3 help Foxp3 [PDF]

Immunity, 2010
In this issue of Immunity, Kerdiles et al. (2010) report that Foxo transcription factors are essential for the development and function of Foxp3-expressing regulatory T (Treg) cells via controlling the expression of genes associated with Treg cell function.
Ohkura, Naganari, Sakaguchi, Shimon
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Anti-regulatory T cell vaccines in immunotherapy: focusing on FoxP3 as target

Human Vaccines & Immunotherapeutics, 2019
Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment.
Neda Mousavi-Niri, Maryam Naseroleslami, Jamshid Hadjati   +2 more
doaj   +1 more source

CD4(+)FoxP3(+) regulatory T-cells in human systemic lupus erythematosus

, 2014
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a loss of immune tolerance to self antigens and by the persistent production of pathogenic autoantibodies.
Suen, Jau-Ling;Chiang, Bor-Luen, 江伯倫   +1 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions

Cancer Management and Research, 2020
Guoming Zeng,1,2,* Libo Jin,3,4,* Qinsi Ying,5 Haojie Chen,3 Murinda Charmaine Thembinkosi,3 Chunguang Yang,6 Jinlong Zhao,6 Hao Ji,3 Sue Lin,3 Renyi Peng,3 Maolan Zhang,1,3 Da Sun3 1Chongqing University of Science and Technology, Chongqing 401331 ...
Zeng G, Jin L, Ying Q, Chen H, Thembinkosi MC, Yang C, Zhao J, Ji H, Lin S, Peng R, Zhang M, Sun D   +11 more
doaj  

Evaluation of the Relationship of PD-L1 and FOXP3 Expressions With Clinicopathological Parameters in Gastric Carcinomas

Forbes Tıp Dergisi, 2021
Objective: At the time of diagnosis, gastric cancers are generally at an advanced stage and the survival rates are very low. The aim of this study is to determine the prognostic values of PD-L1 expression in gastric carcinomas and to detect the presence ...
Sevil Sayhan, Gulden Diniz, Duygu Ayaz, Dudu Solakoglu Kahraman, Pınar Ayvat, Bulent Calik   +5 more
doaj   +1 more source

FOXP3-hESC and NF1-hESC lines differentiate into cells of all three germ layers.

, 2016
(A) FOXP3-hESC and NF1-hESC lines were differentiated into endoderm, mesoderm and ectoderm. Immunofluorescence staining showed expression of SOX17, BRACHYURY and OTX2, representing differentiation into endoderm, mesoderm and ectoderm, respectively. Scale
Julie Baker (3175686), Hui Zhu (87035), Barry Behr (120359), Vikrant V. Reddy (3175683), Mark Hughes (1717240), Yuqiong Pan (227983)   +5 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source