Results 41 to 50 of about 129,408 (207)

Clinical Significance of FOXP3 Expression in BRCA1/2-Mutant Breast Cancer

Zhongliu Fangzhi Yanjiu
ObjectiveTo investigate the potential significance of FOXP3 expression in BRCA1/2-mutant breast cancer. MethodsA total of 48 BRCA mutation carriers (16 with BRCA1 and 32 with BRCA2) and 78 age-matched non-carriers were included in this study ...
Linxi CHEN, Li HU, Jiuan CHEN, Lu YAO, Juan ZHANG, Ye XU, Yuntao XIE   +6 more
doaj   +1 more source

Genetic polymorphism and allele frequency of the FOXP3 gene (rs2232365) in Iraqi patients with rheumatoid arthritis [PDF]

Romanian Journal of Rheumatology
Background. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, leading to joint destruction and disability.
Fatima Sami Hmoud, Manal Badi Salih
doaj   +1 more source

Association of FoxP3/Scurfin Germline Polymorphism (C-2383T/rs3761549) with Colorectal Cancer [PDF]

Iranian Journal of Colorectal Research, 2013
Background FoxP3 gene encodes a transcription factor with crucial roles in the development and function of regulatory T cells. Objectives The present study was conducted to investigate whether the C-2383T (rs3761549) polymorphism in the promoter ...
Zahra Mojtahedi, Nasrollah Erfani, Mohammad Reza Haghshenas, Seyed Vahid Hosseini, Abbas Ghaderi   +4 more
doaj   +1 more source

The correlation between rheumatoid factor and anti cyclic citrullinated peptides with gene expression of FoxP3 in rheumatoid artheritis patients [PDF]

International Journal of Biomedicine and Public Health, 2018
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affect 1-2% of people worldwide. Inflammation is an important factor in the pathogenesis of RA. Anti- Cyclic Citrullinated Peptid (Anti-CCP) antibody and Rheumatoid Factor (RF)
Nasrin Iranshahi, Seyed Mojtaba Amiri, Parisa Zafari, Mahdi Taghaddosi   +3 more
doaj   +1 more source

IPEX as a Result of Mutations in FOXP3 [PDF]

Clinical and Developmental Immunology, 2007
Immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare disorder caused by mutations in theFOXP3gene that result in the defective development ofCD4+CD25+regulatory T cells which constitute an important T cell subset involved in immune homeostasis and protection against autoimmunity.
Hans J. J. van der Vliet, Edward E. Nieuwenhuis   +1 more
openaire   +3 more sources

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce, Wenda Gao, Terry B Strom, Gao Wenda, Strom, Terry B., Strom Terry B., Strom, TB, Putheti, P, Popoola, J, Awasthi, A, Amit Awasthi, Awasthi Amit, Prabhakar Putheti, Popoola Joyce, Awasthi, Amit, Putheti Prabhakar, Joyce Popoola, Gao, W   +17 more
core   +2 more sources

NATURAL REGULATORY T CELLS AND THEIR MOLECULAR MARKER FOXP3 IN FREQUENTLY ILL PRE-SCHOOL CHILDREN LIVING IN AREAS WITH HUMAN-INDUCED IMPACT

Педиатрическая фармакология, 2013
The study presents the review of recent literature on microbial resistance in children suffered from reccurent respiratory infaction (RRI). Special aspects of immune system in children with allergy and acute respiratory infection are discussed. We report
A. D. Pertseva, N. Z. Zokirov, V. V. Troshina, L. S. Namazova-Baranova, S. Y. Tarakanova   +4 more
doaj   +1 more source

Natural T Regulatory Cells (n Treg) in the Peripheral Blood of Healthy Subjects and Subjects with Chronic Periodontitis – A Pilot Study [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: The T cells play a central role in the aetiopathogenesis of periodontal disease. Natural T regulatory cells (nTreg) are the key stone immunoregulatory elements having an anergic phenotype and play an important role in the suppression of
Ram Sabarish, Suresh Ranga Rao, Vamsi Lavu   +2 more
doaj   +1 more source

IPEX Syndrome, FOXP3 and Cancer [PDF]

Journal of Syndromes, 2013
In this review, we introduce the IPEX syndrome and its relationship with germline mutations of the FOXP3 gene. We then describe the multiple functional roles of FOXP3 in regulatory T cells and epithelial cells as well as in IPEX syndrome and tumor progression.
Runhua, Liu, Silin, Li, Wei-Hsiung, Yang, Lizhong, Wang   +3 more
openaire   +2 more sources

CD4(+)FoxP3(+) regulatory T-cells in human systemic lupus erythematosus

, 2014
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a loss of immune tolerance to self antigens and by the persistent production of pathogenic autoantibodies.
Suen, Jau-Ling;Chiang, Bor-Luen, 江伯倫   +1 more
core   +1 more source