Results 71 to 80 of about 134,443 (312)

FOXP3 and NFAT: Partners in Tolerance [PDF]

Cell, 2006
Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional ...
Rudensky, Alexander Y., Gavin, Marc, Zheng, Ye   +2 more
openaire   +2 more sources

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

SIRT1 regulates Foxp3 degradation.

, 2013
(A) HEK293 cells were co-transfected with HA-Foxp3 and Flag-SIRT1 and treated with 2 µM MG132 for 16 hours. Cells were lysed and Foxp3 protein levels were visualized by Western blotting using anti-HA antibodies.
Jorg van Loosdregt (352938), Cornelieke E. G. M. Pals (352946), Paul J. Coffer (105354), Diede Brunen (352940), Eric W. F. Lam (352948), Veerle Fleskens (352943)   +5 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky system

Biophysics and Physicobiology
Understanding the temporal dynamics of T-cell transcription is crucial for insights into immune cell function and development. In this study, we show the features of the Timer-of-Cell-Kinetics-and-Activity (Tocky) system, which enables analysis of ...
Masahiro Ono
doaj   +1 more source

Clinical Significance of FOXP3 Expression in BRCA1/2-Mutant Breast Cancer

Zhongliu Fangzhi Yanjiu
ObjectiveTo investigate the potential significance of FOXP3 expression in BRCA1/2-mutant breast cancer. MethodsA total of 48 BRCA mutation carriers (16 with BRCA1 and 32 with BRCA2) and 78 age-matched non-carriers were included in this study ...
Linxi CHEN, Li HU, Jiuan CHEN, Lu YAO, Juan ZHANG, Ye XU, Yuntao XIE   +6 more
doaj   +1 more source

Association study of FOXP3 gene and the risk of 0020 pre-eclampsia

Clinical and Experimental Hypertension, 2018
Pre-eclampsia (PE) is a multifactorial pregnancy disorder, with serious consequences for both the mother and the fetus. Despite intense studies, the pathophysiology of PE remains enigmatic.
Milad Gholami, Reza Mirfakhraie, Reihaneh Pirjani, Robabeh Taheripanah, Sahar Bayat, Seyyedeh Anita Daryabari, Matina Noori, Sayyed Mohamad Hossein Ghaderian   +7 more
doaj   +1 more source

The relationship between the CD45RA/FoxP3-definded subsets of T cells and CD25/FoxP3-defined Treg cells in SLE.

, 2013
(A) The proportion of CD45RA+ FoxP3low (I), CD45RA−FoxP3high (II), CD45RA−FoxP3low cells (III), CD45RA−FoxP3− cells (IV) and CD45RA−FoxP3− cells (V) were analyzed in relation to CD25 expression in active SLE patients.
Fujun Lin (326910), Xiujun Pan (326906), Jianping Shan (326909), Dakang Xu (326915), Yuan H. Yang (21739), Lisong Shen (326917), Weiwei Wang (105069), Xiangliang Yuan (326907), Yingxia Zheng (326908), Gengru Jiang (326911), Die Wang (326913)   +10 more
core   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Immunohistochemistry method and diagnostics of mycosis fungoides

Vestnik Dermatologii i Venerologii, 2017
Clinical patient examinations are not enough for diagnosing lymphoproliferative skin diseases now. Histological diagnostics is an important auxiliary method; however, it is not always applicable.
A. S. Zhukov, I. E. Belousova, A. V. Samtsov   +2 more
doaj   +1 more source