Results 121 to 130 of about 134,443 (312)

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Table_5_Characterizing Foxp3+ and Foxp3- T cells in the homeostatic state and after allo-activation: resting CD4+Foxp3+ Tregs have molecular characteristics of activated T cells.xlsx

Due to the intracellular expression of Foxp3 it is impossible to purify viable Foxp3+ cells on the basis of Foxp3 staining. Consequently CD4+Foxp3+ regulatory T cells (Tregs) in mice have mostly been characterized using CD4+CD25+ T cells or GFP-Foxp3 ...
Natalie M. Niessen (17844470), Zilei Liu (1357500), Katherine J. Baines (10984584), David Clark (738), Munish K. Heer (17844473), G. Alexander Bishop (17844476), Paul R. Trevillian (17844479)   +6 more
core   +1 more source

Impaired FoxP3 induction in naive Tg4 FoxP3^gfp CD4⁺ T cells.

, 2013
A. In vitro FoxP3 induction in male, naive CD4+CD62L+ T cells by stimulation with peptide and antigen-presenting cells or plate-bound anti-CD3 and anti-CD28 antibody in the presence of IL-2 and TGF-β1 for 7 days. n = 6 each for peptide stimulation, n = 8
Bronwen R. Burton (400298), Johan Verhagen (400297), Graham J. Britton (400299), Ella R. Shepard (400300), Stephen M. Anderton (297580), David C. Wraith (400301)   +5 more
core   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Table_3_Characterizing Foxp3+ and Foxp3- T cells in the homeostatic state and after allo-activation: resting CD4+Foxp3+ Tregs have molecular characteristics of activated T cells.xlsx

Due to the intracellular expression of Foxp3 it is impossible to purify viable Foxp3+ cells on the basis of Foxp3 staining. Consequently CD4+Foxp3+ regulatory T cells (Tregs) in mice have mostly been characterized using CD4+CD25+ T cells or GFP-Foxp3 ...
Natalie M. Niessen (17844470), Zilei Liu (1357500), Katherine J. Baines (10984584), David Clark (738), Munish K. Heer (17844473), G. Alexander Bishop (17844476), Paul R. Trevillian (17844479)   +6 more
core   +1 more source

SIRT1-mediated deacetylation increases Foxp3 poly-ubiquitination.

, 2013
(A) HEK293 cells ectopically expressing HA-Foxp3 were transfected with Flag-SIRT1. Cell lysates were prepared and HA-Foxp3 was immunoprecipitated. Acetylated Foxp3 was visualized by Western blotting using anti-acetylated lysine antibodies.
Jorg van Loosdregt (352938), Cornelieke E. G. M. Pals (352946), Paul J. Coffer (105354), Diede Brunen (352940), Eric W. F. Lam (352948), Veerle Fleskens (352943)   +5 more
core   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Table_4_Characterizing Foxp3+ and Foxp3- T cells in the homeostatic state and after allo-activation: resting CD4+Foxp3+ Tregs have molecular characteristics of activated T cells.xlsx

Due to the intracellular expression of Foxp3 it is impossible to purify viable Foxp3+ cells on the basis of Foxp3 staining. Consequently CD4+Foxp3+ regulatory T cells (Tregs) in mice have mostly been characterized using CD4+CD25+ T cells or GFP-Foxp3 ...
Natalie M. Niessen (17844470), Zilei Liu (1357500), Katherine J. Baines (10984584), David Clark (738), Munish K. Heer (17844473), G. Alexander Bishop (17844476), Paul R. Trevillian (17844479)   +6 more
core   +1 more source

Sensitivity to apoptosis under stimulation in reference to FoxP3 expression.

, 2013
A. CD4+ T cells do not upregulated FoxP3 expression under CD3/CD28 stimulation in mixed splenocyte cultures from FoxP3-GFP transgenes. Apoptosis was determined in control medium and with FasL under CD3 and CD3/CD28 stimulation in (B) gated FoxP3− T cells
Enosh M. Askenasy (349060), Ayelet Kaminitz (349057), Jerry Stein (349062), Esma S. Yolcu (299557), Isaac Yaniv (349064), Haval Shirwan (299564), Nadir Askenasy (349066)   +6 more
core   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source