Results 281 to 290 of about 160,147 (340)

The Human Bone Marrow May Offer an IL-15-Dependent Survival Niche for EOMES⁺ Tr1-Like Cells. [PDF]

Eur J Immunol
Pulvirenti N, Vasco C, Righetti C, Dadova P, Boffa G, Laroni A, Vigo T, Raiola AM, Crosti MC, Maglie S, Valenti L, Prati D, Abrigani S, Uccelli A, Geginat J.   +14 more
europepmc   +1 more source

IFNγ Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy

Allergy, EarlyView.
We used patient samples and a murine model to understand the contribution of Bregs to EoE immunopathology. We find that Breg‐derived IL‐10 is important for controlling EoE, but that Breg expansion and function are impaired in this condition. We identify IFNγ as a key negative regulator of Breg function in mice and patients with EoE. Bregs, regulatory B
Rachel L. Clement, Julie Dilollo, Eric M. Rodríguez‐López, Cleandre M. Guerrier, David A. Hill   +4 more
wiley   +1 more source

GPER1-mediated suppression of acute cellular rejection in murine cervical heart transplantation by estradiol. [PDF]

J Cardiothorac Surg
Liu Y, Wang R, Han B, Zhu B, Ma Y, Yu Y, Bai L, Wei Q, Yang P.   +8 more
europepmc   +1 more source

Echinococcus granulosus antigen B regulates T‐cell function through inhibition of signal transducer and activator of transcription 3 in experimental immune thrombocytopenia

British Journal of Haematology, EarlyView.
During the pathological process of immune thrombocytopenia, signal transducer and activator of transcription 3 (STAT3) is activated by JAKs, leading to the production of a large number of inflammatory cytokines and promoting the activation of Th1, Th2 and Th17 cells.
Yingbin Yue, Yunfei Zhang, Yongfeng Cheng, Hongjie Jiao, Mei Yan   +4 more
wiley   +1 more source

Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application. [PDF]

Cell Death Dis
Pan Y, Zhou H, Sun Z, Zhu Y, Zhang Z, Han J, Liu Y, Wang Q.   +7 more
europepmc   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent T_reg-microglia crosstalk. [PDF]

Nat Neurosci
Izzy S, Yahya T, Albastaki O, Abou-El-Hassan H, Aronchik M, Cao T, De Oliveira MG, Lu KJ, Moreira TG, da Silva P, Boucher ML, Beauchamp LC, S LeServe D, Brandao WN, Carolina Durão A, Lanser T, Montini F, Lee JH, Bernstock JD, Kaul M, Pasquarelli-do-Nascimento G, Chopra K, Krishnan R, Mannix R, Rezende RM, Quintana FJ, Butovsky O, Weiner HL.   +27 more
europepmc   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Calcineurin Inhibitors, but not Rapamycin, Reduce Percentages of CD4+CD25+FOXP3+ Regulatory T Cells in Renal Transplant Recipients

, 2006
David San Segundo, Juan Carlos Ruiz, María Jesús Izquierdo, Gema Fernández‐Fresnedo, C. Gómez-Alamillo, Ramón Merino, M.J. Benito, Eva Cacho, Emilio Rodrigo, R. Palomar, Marcos López‐Hoyos, Manuel Arias   +11 more
openalex   +1 more source

Interaction between nasal epithelial cells and Tregs in allergic rhinitis responses to allergen via CCL1/CCR8. [PDF]

Front Immunol
Sha J, Yang M, Lei Y, Sun L, Meng C, Zhu D.   +5 more
europepmc   +1 more source