Results 291 to 300 of about 171,978 (359)

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

CD8⁺HLA-DR⁺CD27⁺ T cells define a population of naturally occurring regulatory precursors in humans. [PDF]

Sci Adv
Guo H, Wang B, Wu Z, Zhang Q, Jiang X, Zhang F, Zhou J, Fan S, Zhou Y, Xu ZL, Wang Y, Zhao XY, Huang XJ.   +12 more
europepmc   +1 more source

Liposomal 188Rhenium Plus Macrophage Depletion Enhances Anti‐PD‐L1 Efficacy and B Cell Infiltration Against Lung Metastatic Cancer

Cancer Science, EarlyView.
This study demonstrates that combining liposomal Rhenium‐188 (Lipo‐Re188) with macrophage depletion and anti–PD‐L1 therapy enhances therapeutic efficacy against lung metastatic colon cancer. The triple therapy promotes B cell infiltration, restores T cell function, and suppresses MDSC, creating a tumor‐suppressive immune microenvironment.
Shin‐Yi Liu, Liang‐Ting Lin, Chih‐Hsien Chang, Yu‐Jen Chen   +3 more
wiley   +1 more source

Lactic acid improves Treg manufacturing and <i>in vivo</i> function. [PDF]

Mol Ther Methods Clin Dev
Tuomela K, Leong ESY, Haque M, Mangat S, Fung VCW, Garcia RV, Archambault AS, Boardman DA, Klein Geltink RI, Mojibian M, Levings MK.   +10 more
europepmc   +1 more source

Single‐Cell RNA‐Seq Reveals the Effect of Commensal Bacteria on the Multistep Development of Esophageal Cancer

Cancer Science, EarlyView.
These results shed light on the impact of commensal microbiome on phenotypes and transition fates of different cell types across the tumorigenic processes of ESCC and may have implications for ESCC prevention and treatment. ABSTRACT Microbiomes within the tumor microenvironment (TME) are intricately linked to the modulation of cancer cell properties ...
Xuan Xie, Shuyue Zhang, Zihang Mai, Jing Zhan, Sheng Lei, Zhiqiang Ouyang, Zelin Weng, Xiuying Xie, Jingjing Han, Jing Wen   +9 more
wiley   +1 more source

Introducing the Dish Soap Protocol: A Unified Approach for Multi-Modal Intracellular Staining. [PDF]

Curr Protoc
Burton OT, Dooley J, Liston A.
europepmc   +1 more source

Autophagy in PE: Dispute, Role and Potential Target

Cell Proliferation, EarlyView.
Autophagy homeostasis serves as a central hub regulating vascular remodelling during pregnancy. It integrates maternal, genetic, and fetal factors; shapes the functions of immune cells (NK cells, macrophages, and T cells); restrains endothelial inflammatory responses (cytokines, endothelial cell, oxidative/ER stress, and protein aggregation); and ...
Miao Xu, Qi Wang, Fang Wang, Li Kang, Huijing Ma, Mengnan Li, Zhuanghui Hao, Zhengrui Li, Ji'an Liu, Xufeng Huang, Hengrui Liu, Shouxin Wei, Hailan Yang   +12 more
wiley   +1 more source

OGG1 augments the transcriptional activation of <i>Foxp3</i> to promote iTreg differentiation for IBD alleviation. [PDF]

Proc Natl Acad Sci U S A
Tian M, Hao F, Wang X, Zheng X, Wang H, Li J, Li Z, Xia M, Li C, Zhao Z, Han J, Li D, Nakabeppu Y, Boldogh I, Wei M, Ba X.   +15 more
europepmc   +1 more source

Sex as a modifier of genetic risk for type 1 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Sex differences influence the pathogenesis of type 1 diabetes (T1D), yet most genetic studies have treated sex as a control covariate rather than a dynamic effect modifier. Sex influences immune cell behaviour, including CD4+ and CD8+ T cell activation, regulatory T cell stability, B cell autoantibody production, dendritic cell priming and ...
Hui‐Qi Qu, Hakon Hakonarson
wiley   +1 more source

PI3K GOF leads to dysregulation of T and B cells that both contribute to extrinsically driving activation and differentiation of other CD4⁺ T cells. [PDF]

Immunol Cell Biol
Bier J, Lau A, Jackson KJ, Ruiz-Diaz S, Peters TJ, Brink R, Tangye SG, Deenick EK.   +7 more
europepmc   +1 more source