Microstructural injury to the optic nerve with vigabatrin treatment in West syndrome: A DTI study
Scientific ReportsTo evaluate optic nerve injury associated with vigabatrin treatment in children with West syndrome using diffusion tensor imaging. Thirty-five children with West syndrome (aged 9 days–22 months) were retrospectively analyzed and grouped as follows: (1 ...
Junjie Hu +7 more
doaj +1 more source
Orthogonal invariant sets of the diffusion tensor and the development of a curvilinear set suitable for low-anisotropy tissues. [PDF]
PLoS ONE, 2013 We develop a curvilinear invariant set of the diffusion tensor which may be applied to Diffusion Tensor Imaging measurements on tissues and porous media.
Robin A Damion +4 more
doaj +1 more source
Mean fractional anisotropy map from 21 chimpanzees.
, 2013 Mean fractional anisotropy map from 21 chimpanzees.
Kimberley A. Phillips (332996) +1 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Isolated focal dystonia phenotypes are associated with distinct patterns of altered microstructure
NeuroImage: Clinical, 2018 Objective: Isolated adult-onset focal dystonia is considered a network disorder with disturbances to the motor basal ganglia and cerebellar circuits playing a pathophysiological role, but why specific body regions become affected remains unknown.
Brian D. Berman +4 more
doaj +1 more source
White matter fractional anisotropy values from seed-based analysis of fractional anisotropy maps.
, 2013 DTI fractional anisotropy was measured in four different white matter seed regions. Boxplots display for 5-HTT-/- and 5-HTT+/+ animals the average value in each of the regions.
Rick M. Dijkhuizen (316059) +3 more
core +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Fractional anisotropy data for peak voxels of athletes > novices.
, 2019 Fractional anisotropy data for peak voxels of athletes > novices.
Yan-Ling Pi (6307811) +6 more
core +1 more source
Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
FEBS Open Bio, EarlyView.Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley +1 more source