Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Memory effects in measure transport equations
, 2019 Transport equations with a nonlocal velocity field have been introduced as a continuum model for interacting particle systems arising in physics, chemistry and biology.
Camilli, Fabio, De Maio, Raul
core +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Properties of a subclass of analytic functions defined by Riemann-Liouville fractional integral applied to convolution product of multiplier transformation and Ruscheweyh derivative [PDF]
, 2023 Alina Alb Lupaş, Mugur Acu
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Type of Leibniz Rule on Riemann-Liouville Variable-Order Fractional\n Integral and Derivative Operator [PDF]
, 2021 Dagnachew Jenber, Mollalign Haile
openalex +2 more sources
Generalized Fractional ρ,k,φ-Proportional Hilfer Derivatives and Some Properties
Journal of MathematicsBuilding on previous work in fractional calculus, this paper introduces new definitions for the ρ,k,φ-proportional integral and ρ,k,φ-proportional H fractional derivative.
Haihua Wang
doaj +1 more source
Non-Instantaneous Impulsive Boundary Value Problems Containing Caputo Fractional Derivative of a Function with Respect to Another Function and Riemann–Stieltjes Fractional Integral Boundary Conditions [PDF]
, 2021 Suphawat Asawasamrit +3 more
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Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
On fractional derivatives with generalized Mittag-Leffler kernels
Advances in Difference Equations, 2018 Fractional derivatives with three parameter generalized Mittag-Leffler kernels and their properties are studied. The corresponding integral operators are obtained with the help of Laplace transforms.
Thabet Abdeljawad, Dumitru Baleanu
doaj +1 more source