Results 51 to 60 of about 3,730 (264)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Certain inequalities via generalized proportional Hadamard fractional integral operators

Advances in Difference Equations, 2019
In the article, we introduce the generalized proportional Hadamard fractional integrals and establish several inequalities for convex functions in the framework of the defined class of fractional integrals.
Gauhar Rahman, Thabet Abdeljawad, Fahd Jarad, Aftab Khan, Kottakkaran Sooppy Nisar   +4 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Some New Approaches to Fractional Euler–Maclaurin-Type Inequalities via Various Function Classes

Fractal and Fractional
This paper aims to examine an approach that studies many Euler–Maclaurin-type inequalities for various function classes applying Riemann–Liouville fractional integrals.
Mehmet Gümüş, Fatih Hezenci, Hüseyin Budak   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Partial, Composite Fractional Operators, and Their Properties and Applications

MATEC Web of Conferences, 2017
The paper discusses the properties of the partial fractional integrals, the partial fractional derivatives, and the composite fractional integrals and derivatives.
Deng Kaiying, Deng Jingwei, Li Suduo
doaj   +1 more source

Fractional Definite Integral [PDF]

Fractal and Fractional, 2017
This paper proposes the definition of fractional definite integral and analyses the corresponding fundamental theorem of fractional calculus. In this context, we studied the relevant properties of the fractional derivatives that lead to such a definition. Finally, integrals on R2 R 2 and R3 R 3 are also proposed.
Manuel Ortigueira, José Machado
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Elements of fractional calculus. Fractional integrals

Bulletin of Taras Shevchenko National University of Kyiv. Series: Physics and Mathematics, 2022
The paper is devoted to the basic properties of fractional integrals. It is a survey of the well-known properties of fractional integrals, however, the authors tried to present the known information about fractional integrals as short and transparently as possible. We introduce fractional integrals on the compact interval and on the semi-axes, consider
Yuliya Mishura, Olha Hopkalo, Hanna Zhelezniak   +2 more
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source