A micromechanical fracture analysis to investigate the effect of healing particles on the overall mechanical response of a self-healing particulate composite [PDF]
, 2019 A computational fracture analysis is conducted on a self‐healing particulate composite employing a finite element model of an actual microstructure. The key objective is to quantify the effects of the actual morphology and the fracture properties of the ...
Krishnasamy, J. +3 more
core +5 more sources
Age-related changes to macrophages are detrimental to fracture healing in mice. [PDF]
, 2020 The elderly population suffers from higher rates of complications during fracture healing that result in increased morbidity and mortality. Inflammatory dysregulation is associated with increased age and is a contributing factor to the myriad of age ...
Brazina, Sloane +8 more
core +2 more sources
Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing [PDF]
, 2020 Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs) negatively influence bone metabolism and fracture healing.
Brinkman, Antonia Clara Katharina +10 more
core +1 more source
Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy [PDF]
, 2020 Purpose: The classic fracture model, described by Bonnarens and Einhorn in 1984, enlists a blunt guillotine to generate a closed fracture in a pre-stabilized rodent femur.
Akkus, O. +6 more
core +1 more source
Accelerated Calvarial Healing in Mice Lacking Toll-Like Receptor 4 [PDF]
, 2012 The bone and immune systems are closely interconnected. The immediate inflammatory response after fracture is known to trigger a healing cascade which plays an important role in bone repair.
Adam A. Kubala +7 more
core +5 more sources
Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels [PDF]
, 2019 Macrophages are essential players in the process of fracture healing, acting by remodeling of the extracellular matrix and enabling vascularization. Whilst activated macrophages of M1-like phenotype are present in the initial pro-inflammatory phase of ...
Aulich, Linus +11 more
core +1 more source
VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing [PDF]
, 2018 A significant number of fractures develop non‐union. Mesenchymal stem cell (MSC) therapy may be beneficial, however, this requires cell acquisition, culture and delivery. Endogenous mobilization of stem cells offers a non‐invasive alternative.
Blunn, G +3 more
core +4 more sources
Fracture healing following high energy tibial trauma: Ilizarov versus Taylor Spatial Frame [PDF]
, 2014 Introduction: The optimal treatment of high energy tibial fractures remains controversial and a challenging orthopaedic problem. The role of external fi xators for all these tibial fractures has been shown to be crucial. Methods: A fi ve-year consecutive
AS Rigby +11 more
core +1 more source
Computer simulation of fatigue under diametrical compression [PDF]
, 2007 We study the fatigue fracture of disordered materials by means of computer simulations of a discrete element model. We extend a two-dimensional fracture model to capture the microscopic mechanisms relevant for fatigue, and we simulate the diametric ...
Andrade Jr., J. S. +3 more
core +2 more sources
Early pH Changes in Musculoskeletal Tissues upon Injury-Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH [PDF]
, 2020 Local pH is stated to acidify after bone fracture. However, the time course and degree of acidification remain unknown. Whether the acidification pattern within a fracture hematoma is applicable to adjacent muscle hematoma or is exclusive to this ...
Berkmann, Julia C. +8 more
core +2 more sources