Results 1 to 10 of about 897,836 (307)

The local and systemic effects of immune function on fracture healing

OTA International
. The immune system plays an integral role in the regulation of cellular processes responsible for fracture healing. Local and systemic influences on fracture healing correlate in many ways with fracture-related outcomes, including soft tissue healing ...
Andrew R. Evans, MD, Peter V. Giannoudis, BSc, MD, PhD, FRCS, FACS, Philip Leucht, MD, Todd O. McKinley, MD, Greg E. Gaski, MD, Katherine P. Frey, PhD, RN, Joseph C. Wenke, MD, Christopher Lee, MD   +7 more
doaj   +1 more source

THE EFFECT OF DENERVATION ON FRACTURE HEALING , AN EXPERIMENTAL STUDY ON RABBITS [PDF]

Basrah Journal of Surgery, 2014
THE EFFECT OF DENERVATION ON FRACTURE HEALING , AN EXPERIMENTAL STUDY ON RABBITS Thamer A Hamdan , Mubder A Mohammed Saeed & Abbas Salman Ismael Abstract Many studies suggested a relation between denervation and fracture healing either in positive or ...
THAMIR A. HAMDAN, Mubder A Mohammed Saeed, Abbas Salman ISMAEL   +2 more
doaj   +1 more source

Glucosamine-Sulfate On Fracture Healing

Turkish Journal of Trauma and Emergency Surgery, 2013
The aim of this study is to determine whether glucosamine-sulfate has any effects on bone-healing.A unilateral fracture was created in the tibia of sixty-one female rats. Rats were given no drug or 230 mg/kg glucosamine-sulfate daily. Fractures were analyzed during the first, second and fourth weeks after creation of fracture.
Uğraş, Akın, Güzel, Elif, Korkusuz, Petek, Kaya, İbrahim, Dikici, Fatih, Demirbaş, Emrah, Çetinüs, Ercan   +6 more
openaire   +6 more sources

Finite element simulations of smart fracture plates capable of cyclic shortening and lengthening: which stroke for which fracture?

Frontiers in Bioengineering and Biotechnology
Introduction: Bone healing can be improved by axial micromovement, as has been shown in animals and human patients with external fixators. In the development of smart fracture plates, the ideal amount of stroke for different fracture types in the ...
Michael Roland, Stefan Diebels, Kerstin Wickert, Tim Pohlemann, Bergita Ganse, Bergita Ganse   +5 more
doaj   +1 more source

Fracture Healing Is Delayed in Immunodeficient NOD/scid‑IL2Rγcnull Mice. [PDF]

PLoS ONE, 2016
Following bone fracture, the repair process starts with an inflammatory reaction at the fracture site. Fracture healing is disturbed when the initial inflammation is increased or prolonged, whereby, a balanced inflammatory response is anticipated to be ...
Anna E Rapp, Ronny Bindl, Stefan Recknagel, Annika Erbacher, Ingo Müller, Hubert Schrezenmeier, Christian Ehrnthaller, Florian Gebhard, Anita Ignatius   +8 more
doaj   +1 more source

The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis

Clinics, 2019
The very large economic and social burdens of fracture-related complications make rapid fracture healing a major public health goal. The role of parathyroid hormone (PTH) in treating osteoporosis is generally accepted, but the effect of PTH on fracture ...
Hao Hong, Ting Song, Yang Liu, Jun Li, Qilong Jiang, Qizhi Song, Zhongliang Deng   +6 more
doaj   +1 more source

Exploring the role of OIP5-AS1 in the mechanisms of delayed fracture healing: functional insights and clinical implications

Journal of Orthopaedic Surgery and Research
Objective Fracture is a common traumatic disease and there is a risk of delayed healing after fracture occurs. This study aimed to explore the regulatory roles and clinical implications of OIP5-AS1 in delayed fracture healing.
Yusen Hu, Meini Cen, Yi Hu
doaj   +1 more source

Effects of local and systemic ketorolac application on rat femur fracture healing

OTA International
. Objectives:. Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently administered in patients with orthopaedic trauma because of their effectiveness in pain reduction and managing inflammation, but clinicians are concerned regarding the ...
Bailey V. Fearing, PhD, Katherine K. Li, MD, Sarah M. Romereim, PhD, Matthew R. Smykowski, BS, K. Eddie Afetse, BS, BA, Elaina K. Ball, BS, Susan Odum, PhD, Marc Duemmler, MS, Nahir A. Habet, MS, Rachel B. Seymour, PhD, Joseph R. Hsu, MD   +10 more
doaj   +1 more source

PRMT6 inhibitors promote fracture healing by modulating osteoclast glucose metabolism

Frontiers in Immunology
IntroductionImpaired fracture healing remains a significant clinical challenge due to the complexity of the healing process. Osteoclasts, derived from monocytes, are pivotal in bone tissue reconstruction, yet no effective clinical tools exist to promote ...
Nan Wu, Renkai Wang, Shensheng Nian, Hao Zhang, Panyu Zhou, Hao Tang   +5 more
doaj   +1 more source

Low‐dose TNF augments fracture healing in normal and osteoporotic bone by up‐regulating the innate immune response

EMBO Molecular Medicine, 2015
The mechanism by which trauma initiates healing remains unclear. Precise understanding of these events may define interventions for accelerating healing that could be translated to the clinical arena.
James K Chan, Graeme E Glass, Adel Ersek, Andrew Freidin, Garry A Williams, Kate Gowers, Ana I Espirito Santo, Rosemary Jeffery, William R Otto, Richard Poulsom, Marc Feldmann, Sara M Rankin, Nicole J Horwood, Jagdeep Nanchahal   +13 more
doaj   +1 more source