Results 1 to 10 of about 1,759,920 (268)
Age‐related changes to macrophages are detrimental to fracture healing in mice [PDF]
Aging Cell, 2020 The elderly population suffers from higher rates of complications during fracture healing that result in increased morbidity and mortality. Inflammatory dysregulation is associated with increased age and is a contributing factor to the myriad of age ...
D. Clark +8 more
semanticscholar +4 more sources
Cell Proliferation, 2019 Exosomes, as important players in intercellular communication due to their ability to transfer certain molecules to target cells, are believed to take similar effects in promoting bone regeneration with their derived stem cells.
Yun-tong Zhang +7 more
semanticscholar +3 more sources
Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence.
Endocrine reviews, 2022 Over 2.1 million age-related fractures occur in the United States annually, resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of bone structure is associated with impaired bone healing. Fracture healing is a dynamic
D. Saul, S. Khosla
semanticscholar +1 more source
Advancement of science, 2021 The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited.
Jie Mi +16 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Bone fracture represents a significant problem in public health. State-of-the-art clinical study demonstrated that by correlating the stimulation amplitude and frequency directly to dynamic locomotion, biofeedback electrostimulation therapy ...
Guang Yao +12 more
semanticscholar +1 more source
Stem cell research & therapeutics, 2020 As important players in cell-to-cell communication, exosomes (exo) are believed to play a similar role in promoting fracture healing. This study investigated whether exosomes derived from bone marrow mesenchymal stem cells (BMMSC-Exos) could improve ...
Lu Zhang +9 more
semanticscholar +1 more source
Heterogeneity of murine periosteum progenitors involved in fracture healing
bioRxiv, 2020 The periosteum is the major source of cells involved in fracture healing. We sought to characterize progenitor cells and their contribution to bone fracture healing. The periosteum is highly enriched for progenitor cells, including Sca1+ cells, CFU-F and
B. Matthews +7 more
semanticscholar +1 more source
The Role of the Immune Cells in Fracture Healing
Current Osteoporosis Reports, 2018 Purpose of reviewBone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of ...
G. Baht, Linda Vi, B. Alman
semanticscholar +1 more source
Cellular biology of fracture healing
Journal of Orthopaedic Research, 2018 The biology of bone healing is a rapidly developing science. Advances in transgenic and gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal regeneration.
C. Bahney +8 more
semanticscholar +1 more source
The Impact of Type 2 Diabetes on Bone Fracture Healing
Frontiers in Endocrinology, 2018 Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease known by the presence of elevated blood glucose levels. Nowadays, it is perceived as a worldwide epidemic, with a very high socioeconomic impact on public health.
C. Marín +4 more
semanticscholar +1 more source