Results 1 to 10 of about 1,704,060 (353)
Modulation of fracture healing by the transient accumulation of senescent cells
eLife, 2021 Senescent cells have detrimental effects across tissues with aging but may have beneficial effects on tissue repair, specifically on skin wound healing. However, the potential role of senescent cells in fracture healing has not been defined.
Dominik Saul +7 more
doaj +2 more sources
The biology of fracture healing. [PDF]
Injury, 2011 The biology of fracture healing is a complex biological process that follows specific regenerative patterns and involves changes in the expression of several thousand genes. Although there is still much to be learned to fully comprehend the pathways of bone regeneration, the over-all pathways of both the anatomical and biochemical events have been ...
R. Marsell, T. Einhorn
semanticscholar +4 more sources
Cell Proliferation, 2019 Exosomes, as important players in intercellular communication due to their ability to transfer certain molecules to target cells, are believed to take similar effects in promoting bone regeneration with their derived stem cells.
Zichen Hao, Demeng Xia, Shuogui Xu
exaly +2 more sources
Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model
Stem Cells Translational Medicine, 2016 Paracrine signaling by bone‐marrow‐derived mesenchymal stem cells (MSCs) plays a major role in tissue repair. Although the production of regulatory cytokines by MSC transplantation is a critical modulator of tissue regeneration, we focused on exosomes ...
Taisuke Furuta +2 more
exaly +2 more sources
Osteoimmunology of Fracture Healing. [PDF]
Curr Osteoporos RepAbstract Purpose of Review The purpose of this review is to summarize what is known in the literature about the role inflammation plays during bone fracture healing. Bone fracture healing progresses through four distinct yet overlapping phases: formation of the hematoma, development of the cartilaginous callus ...
Molitoris KH, Huang M, Baht GS.
europepmc +3 more sources
Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis.
PLoS ONE, 2016 PurposeNowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn't come to an agreement.
Zhongju Shi +7 more
doaj +2 more sources
Effects of Aging on Fracture Healing [PDF]
Current Osteoporosis Reports, 2017 This review summarizes research on the physiological changes that occur with aging and the resulting effects on fracture healing.Aging affects the inflammatory response during fracture healing through senescence of the immune response and increased systemic pro-inflammatory status.
D. Clark +3 more
semanticscholar +6 more sources
Near-Infrared Spectroscopy Allows for Monitoring of Bone Fracture Healing via Changes in Oxygenation [PDF]
Journal of Functional BiomaterialsBone fractures are associated with hypoxia, but no longitudinal studies of perfusion measurements in human patients have been reported despite the clinical and research potential.
Cedric Nowicki, Bergita Ganse
doaj +2 more sources
PLoS ONE, 2016 Biomechanical tests are widely used in animal studies on osteoporotic fracture healing. However, the biomechanical recovery process is still unknown, leading to difficulty in choosing time points for biomechanical tests and in correctly assessing ...
Lin Chen +6 more
doaj +2 more sources
Exploring the role of OIP5-AS1 in the mechanisms of delayed fracture healing: functional insights and clinical implications [PDF]
Journal of Orthopaedic Surgery and ResearchObjective Fracture is a common traumatic disease and there is a risk of delayed healing after fracture occurs. This study aimed to explore the regulatory roles and clinical implications of OIP5-AS1 in delayed fracture healing.
Yusen Hu, Meini Cen, Yi Hu
doaj +2 more sources