miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway [PDF]
Experimental and Molecular Medicine, 2021 Bone marrow mesenchymal stem cell (BMSC)-derived exosomes have been found to enhance fracture healing. In addition, microRNAs contributing to the healing of various bone fractures have attracted widespread attention in recent years, but knowledge of the ...
Yan Huang +5 more
openalex +2 more sources
Advances in Animal Models for Studying Bone Fracture Healing
Bioengineering, 2023 Fracture is a common traumatic injury that is mostly caused by traffic accidents, falls, and falls from height. Fracture healing is a long-term and complex process, and the mode of repair and rate of healing are influenced by a variety of factors.
Hui Gao +3 more
semanticscholar +1 more source
Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence.
Endocrine reviews, 2022 Over 2.1 million age-related fractures occur in the United States annually, resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of bone structure is associated with impaired bone healing. Fracture healing is a dynamic
D. Saul, S. Khosla
semanticscholar +1 more source
SATB2 promotes humeral fracture healing in rats by activating the PI3K/AKT pathway. [PDF]
Open Life SciLiu L +6 more
europepmc +2 more sources
Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing
International Journal on Biological Sciences, 2022 The biomechanical environment plays a dominant role in fracture healing, and Piezo1 is regarded as a major mechanosensor in bone homeostasis. However, the role of Piezo1 in fracture healing is not yet well characterized.
Yunlu Liu +11 more
semanticscholar +1 more source
Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice
Journal of Clinical Investigation, 2022 Cellular senescence plays an important role in human diseases, including osteoporosis and osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory phenotype to affect the function of neighboring cells and SCs themselves.
Jiatong Liu +5 more
semanticscholar +1 more source
Advancement of science, 2021 The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited.
Jie Mi +16 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Bone fracture represents a significant problem in public health. State-of-the-art clinical study demonstrated that by correlating the stimulation amplitude and frequency directly to dynamic locomotion, biofeedback electrostimulation therapy ...
Guang Yao +12 more
semanticscholar +1 more source
Modulation of fracture healing by the transient accumulation of senescent cells
bioRxiv, 2021 Senescent cells have detrimental effects across tissues with aging but may have beneficial effects on tissue repair, specifically on skin wound healing. However, the potential role of senescent cells in fracture healing has not been defined.
D. Saul +7 more
semanticscholar +1 more source
Single-Cell RNA Sequencing Reveals B Cells Are Important Regulators in Fracture Healing
Frontiers in Endocrinology, 2021 The bone marrow microenvironment is composed primarily of immune and stromal cells that play important roles in fracture healing. Although immune cells have been identified in mouse bone marrow, variations in their numbers and type during the fracture ...
Hao Zhang +10 more
semanticscholar +1 more source