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Modulation of fracture healing by the transient accumulation of senescent cells

open access: yeseLife, 2021
Senescent cells have detrimental effects across tissues with aging but may have beneficial effects on tissue repair, specifically on skin wound healing. However, the potential role of senescent cells in fracture healing has not been defined.
Dominik Saul   +7 more
doaj   +2 more sources

The biology of fracture healing. [PDF]

open access: yesInjury, 2011
The biology of fracture healing is a complex biological process that follows specific regenerative patterns and involves changes in the expression of several thousand genes. Although there is still much to be learned to fully comprehend the pathways of bone regeneration, the over-all pathways of both the anatomical and biochemical events have been ...
R. Marsell, T. Einhorn
semanticscholar   +4 more sources

Exosomes from human umbilical cord mesenchymal stem cells enhance fracture healing through HIF‐1α‐mediated promotion of angiogenesis in a rat model of stabilized fracture

open access: yesCell Proliferation, 2019
Exosomes, as important players in intercellular communication due to their ability to transfer certain molecules to target cells, are believed to take similar effects in promoting bone regeneration with their derived stem cells.
Zichen Hao, Demeng Xia, Shuogui Xu
exaly   +2 more sources

Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model

open access: yesStem Cells Translational Medicine, 2016
Paracrine signaling by bone‐marrow‐derived mesenchymal stem cells (MSCs) plays a major role in tissue repair. Although the production of regulatory cytokines by MSC transplantation is a critical modulator of tissue regeneration, we focused on exosomes ...
Taisuke Furuta   +2 more
exaly   +2 more sources

Osteoimmunology of Fracture Healing. [PDF]

open access: yesCurr Osteoporos Rep
Abstract Purpose of Review The purpose of this review is to summarize what is known in the literature about the role inflammation plays during bone fracture healing. Bone fracture healing progresses through four distinct yet overlapping phases: formation of the hematoma, development of the cartilaginous callus ...
Molitoris KH, Huang M, Baht GS.
europepmc   +3 more sources

Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis.

open access: yesPLoS ONE, 2016
PurposeNowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn't come to an agreement.
Zhongju Shi   +7 more
doaj   +2 more sources

Effects of Aging on Fracture Healing [PDF]

open access: yesCurrent Osteoporosis Reports, 2017
This review summarizes research on the physiological changes that occur with aging and the resulting effects on fracture healing.Aging affects the inflammatory response during fracture healing through senescence of the immune response and increased systemic pro-inflammatory status.
D. Clark   +3 more
semanticscholar   +6 more sources

Near-Infrared Spectroscopy Allows for Monitoring of Bone Fracture Healing via Changes in Oxygenation [PDF]

open access: yesJournal of Functional Biomaterials
Bone fractures are associated with hypoxia, but no longitudinal studies of perfusion measurements in human patients have been reported despite the clinical and research potential.
Cedric Nowicki, Bergita Ganse
doaj   +2 more sources

Biomechanical Characteristics of Osteoporotic Fracture Healing in Ovariectomized Rats: A Systematic Review.

open access: yesPLoS ONE, 2016
Biomechanical tests are widely used in animal studies on osteoporotic fracture healing. However, the biomechanical recovery process is still unknown, leading to difficulty in choosing time points for biomechanical tests and in correctly assessing ...
Lin Chen   +6 more
doaj   +2 more sources

Exploring the role of OIP5-AS1 in the mechanisms of delayed fracture healing: functional insights and clinical implications [PDF]

open access: yesJournal of Orthopaedic Surgery and Research
Objective Fracture is a common traumatic disease and there is a risk of delayed healing after fracture occurs. This study aimed to explore the regulatory roles and clinical implications of OIP5-AS1 in delayed fracture healing.
Yusen Hu, Meini Cen, Yi Hu
doaj   +2 more sources

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