Results 1 to 10 of about 190,164 (332)

Low‐dose TNF augments fracture healing in normal and osteoporotic bone by up‐regulating the innate immune response [PDF]

EMBO Molecular Medicine, 2015
The mechanism by which trauma initiates healing remains unclear. Precise understanding of these events may define interventions for accelerating healing that could be translated to the clinical arena.
James K Chan, Graeme E Glass, Adel Ersek, Andrew Freidin, Garry A Williams, Kate Gowers, Ana I Espirito Santo, Rosemary Jeffery, William R Otto, Richard Poulsom, Marc Feldmann, Sara M Rankin, Nicole J Horwood, Jagdeep Nanchahal   +13 more
doaj   +2 more sources

PRMT6 inhibitors promote fracture healing by modulating osteoclast glucose metabolism [PDF]

Frontiers in Immunology
IntroductionImpaired fracture healing remains a significant clinical challenge due to the complexity of the healing process. Osteoclasts, derived from monocytes, are pivotal in bone tissue reconstruction, yet no effective clinical tools exist to promote ...
Nan Wu, Renkai Wang, Shensheng Nian, Hao Zhang, Panyu Zhou, Hao Tang   +5 more
doaj   +2 more sources

A micromechanical fracture analysis to investigate the effect of healing particles on the overall mechanical response of a self-healing particulate composite [PDF]

, 2019
A computational fracture analysis is conducted on a self‐healing particulate composite employing a finite element model of an actual microstructure. The key objective is to quantify the effects of the actual morphology and the fracture properties of the ...
Krishnasamy, J., Ponnusami, S. A., Turteltaub, S., van der Zwaag, S.   +3 more
core   +10 more sources

Gait Analysis to Monitor Fracture Healing of the Lower Leg

Bioengineering, 2023
Fracture healing is typically monitored by infrequent radiographs. Radiographs come at the cost of radiation exposure and reflect fracture healing with a time lag due to delayed fracture mineralization following increases in stiffness.
Elke Warmerdam, Marcel Orth, Tim Pohlemann, Bergita Ganse   +3 more
doaj   +1 more source

Joint Cartilage in Long-Duration Spaceflight

Biomedicines, 2022
This review summarizes the current literature available on joint cartilage alterations in long-duration spaceflight. Evidence from spaceflight participants is currently limited to serum biomarker data in only a few astronauts.
Bergita Ganse, Magali Cucchiarini, Henning Madry   +2 more
doaj   +1 more source

Simulation-based prediction of bone healing and treatment recommendations for lower leg fractures: Effects of motion, weight-bearing and fibular mechanics

Frontiers in Bioengineering and Biotechnology, 2023
Despite recent experimental and clinical progress in the treatment of tibial and fibular fractures, in clinical practice rates of delayed bone healing and non-union remain high.
Marcel Orth, Bergita Ganse, Bergita Ganse, Annchristin Andres, Kerstin Wickert, Elke Warmerdam, Max Müller, Stefan Diebels, Michael Roland, Tim Pohlemann   +9 more
doaj   +1 more source

Effects of age, body height, body weight, body mass index and handgrip strength on the trajectory of the plantar pressure stance-phase curve of the gait cycle

Frontiers in Bioengineering and Biotechnology, 2023
The analysis of gait patterns and plantar pressure distributions via insoles is increasingly used to monitor patients and treatment progress, such as recovery after surgeries.
Christian Wolff, Patrick Steinheimer, Elke Warmerdam, Tim Dahmen, Philipp Slusallek, Christian Schlinkmann, Fei Chen, Marcel Orth, Tim Pohlemann, Bergita Ganse, Bergita Ganse   +10 more
doaj   +1 more source

Age-related changes to macrophages are detrimental to fracture healing in mice. [PDF]

, 2020
The elderly population suffers from higher rates of complications during fracture healing that result in increased morbidity and mortality. Inflammatory dysregulation is associated with increased age and is a contributing factor to the myriad of age ...
Brazina, Sloane, Clark, Daniel, Hsieh, Christine L, Hu, Diane, Marcucio, Ralph, Miclau, Theodore, Nakamura, Mary C, Niemi, Erene C, Yang, Frank   +8 more
core   +2 more sources

The biology of fracture healing [PDF]

Injury, 2011
The biology of fracture healing is a complex biological process that follows specific regenerative patterns and involves changes in the expression of several thousand genes. Although there is still much to be learned to fully comprehend the pathways of bone regeneration, the over-all pathways of both the anatomical and biochemical events have been ...
Richard, Marsell, Thomas A, Einhorn
openaire   +2 more sources

A Deep Learning Approach for Gait Event Detection from a Single Shank-Worn IMU: Validation in Healthy and Neurological Cohorts

Sensors, 2022
Many algorithms use 3D accelerometer and/or gyroscope data from inertial measurement unit (IMU) sensors to detect gait events (i.e., initial and final foot contact).
Robbin Romijnders, Elke Warmerdam, Clint Hansen, Gerhard Schmidt, Walter Maetzler   +4 more
doaj   +1 more source