Results 1 to 10 of about 1,706,253 (211)
Modulation of fracture healing by the transient accumulation of senescent cells
eLife, 2021 Senescent cells have detrimental effects across tissues with aging but may have beneficial effects on tissue repair, specifically on skin wound healing. However, the potential role of senescent cells in fracture healing has not been defined.
Dominik Saul +7 more
doaj +2 more sources
Cell Proliferation, 2019 Exosomes, as important players in intercellular communication due to their ability to transfer certain molecules to target cells, are believed to take similar effects in promoting bone regeneration with their derived stem cells.
Zichen Hao, Demeng Xia, Shuogui Xu
exaly +2 more sources
Mesenchymal Stem Cell-Derived Exosomes Promote Fracture Healing in a Mouse Model
Stem Cells Translational Medicine, 2016 Paracrine signaling by bone‐marrow‐derived mesenchymal stem cells (MSCs) plays a major role in tissue repair. Although the production of regulatory cytokines by MSC transplantation is a critical modulator of tissue regeneration, we focused on exosomes ...
Taisuke Furuta +2 more
exaly +2 more sources
Effectiveness of Teriparatide on Fracture Healing: A Systematic Review and Meta-Analysis.
PLoS ONE, 2016 PurposeNowadays, the efficacy of teriparatide in treating osteoporosis was widely accepted, but the discussion about using teriparatide to enhance fracture healing hasn't come to an agreement.
Zhongju Shi +7 more
doaj +2 more sources
PLoS ONE, 2016 Biomechanical tests are widely used in animal studies on osteoporotic fracture healing. However, the biomechanical recovery process is still unknown, leading to difficulty in choosing time points for biomechanical tests and in correctly assessing ...
Lin Chen +6 more
doaj +2 more sources
Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence.
Endocrine reviews, 2022 Over 2.1 million age-related fractures occur in the United States annually, resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of bone structure is associated with impaired bone healing. Fracture healing is a dynamic
D. Saul, S. Khosla
semanticscholar +1 more source
Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing
International Journal on Biological Sciences, 2022 The biomechanical environment plays a dominant role in fracture healing, and Piezo1 is regarded as a major mechanosensor in bone homeostasis. However, the role of Piezo1 in fracture healing is not yet well characterized.
Yunlu Liu +11 more
semanticscholar +1 more source
Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice
Journal of Clinical Investigation, 2022 Cellular senescence plays an important role in human diseases, including osteoporosis and osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory phenotype to affect the function of neighboring cells and SCs themselves.
Jiatong Liu +5 more
semanticscholar +1 more source
Gait Analysis to Monitor Fracture Healing of the Lower Leg
Bioengineering, 2023 Fracture healing is typically monitored by infrequent radiographs. Radiographs come at the cost of radiation exposure and reflect fracture healing with a time lag due to delayed fracture mineralization following increases in stiffness.
Elke Warmerdam +3 more
doaj +1 more source
Advancement of science, 2021 The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited.
Jie Mi +16 more
semanticscholar +1 more source