Results 1 to 10 of about 1,593,826 (46)

Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence.

open access: yesEndocrine reviews, 2022
Over 2.1 million age-related fractures occur in the United States annually, resulting in an immense socioeconomic burden. Importantly, the age-related deterioration of bone structure is associated with impaired bone healing. Fracture healing is a dynamic
D. Saul, S. Khosla
semanticscholar   +1 more source

Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene‐Related Peptide

open access: yesAdvancement of science, 2021
The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited.
Jie Mi   +16 more
semanticscholar   +1 more source

A self-powered implantable and bioresorbable electrostimulation device for biofeedback bone fracture healing

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2021
Significance Bone fracture represents a significant problem in public health. State-of-the-art clinical study demonstrated that by correlating the stimulation amplitude and frequency directly to dynamic locomotion, biofeedback electrostimulation therapy ...
Guang Yao   +12 more
semanticscholar   +1 more source

Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion

open access: yesStem cell research & therapeutics, 2020
As important players in cell-to-cell communication, exosomes (exo) are believed to play a similar role in promoting fracture healing. This study investigated whether exosomes derived from bone marrow mesenchymal stem cells (BMMSC-Exos) could improve ...
Lu Zhang   +9 more
semanticscholar   +1 more source

Age‐related changes to macrophages are detrimental to fracture healing in mice

open access: yesAging Cell, 2020
The elderly population suffers from higher rates of complications during fracture healing that result in increased morbidity and mortality. Inflammatory dysregulation is associated with increased age and is a contributing factor to the myriad of age ...
D. Clark   +8 more
semanticscholar   +1 more source

Heterogeneity of murine periosteum progenitors involved in fracture healing

open access: yesbioRxiv, 2020
The periosteum is the major source of cells involved in fracture healing. We sought to characterize progenitor cells and their contribution to bone fracture healing. The periosteum is highly enriched for progenitor cells, including Sca1+ cells, CFU-F and
B. Matthews   +7 more
semanticscholar   +1 more source

Exosomes from human umbilical cord mesenchymal stem cells enhance fracture healing through HIF‐1α‐mediated promotion of angiogenesis in a rat model of stabilized fracture

open access: yesCell Proliferation, 2019
Exosomes, as important players in intercellular communication due to their ability to transfer certain molecules to target cells, are believed to take similar effects in promoting bone regeneration with their derived stem cells.
Yun-tong Zhang   +7 more
semanticscholar   +1 more source

The Role of the Immune Cells in Fracture Healing

open access: yesCurrent Osteoporosis Reports, 2018
Purpose of reviewBone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of ...
G. Baht, Linda Vi, B. Alman
semanticscholar   +1 more source

Cellular biology of fracture healing

open access: yesJournal of Orthopaedic Research, 2018
The biology of bone healing is a rapidly developing science. Advances in transgenic and gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal regeneration.
C. Bahney   +8 more
semanticscholar   +1 more source

The Impact of Type 2 Diabetes on Bone Fracture Healing

open access: yesFrontiers in Endocrinology, 2018
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease known by the presence of elevated blood glucose levels. Nowadays, it is perceived as a worldwide epidemic, with a very high socioeconomic impact on public health.
C. Marín   +4 more
semanticscholar   +1 more source

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