Results 1 to 10 of about 1,770,950 (407)

The effect of osteoporosis and its treatment on fracture healing a systematic review of animal and clinical studies

Bone Reports, 2021
Introduction: Osteoporosis is characterised by low bone mass and micro-architectural deterioration of bone structure. Its treatment is directed at the processes of bone formation or resorption, that are of utmost importance in fracture healing.
E.A. Gorter, C.R. Reinders, P. Krijnen, N.M. Appelman-Dijkstra, I.B. Schipper   +4 more
doaj  

Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat [PDF]

, 2008
Background Fracture healing in osteoporosis is delayed. Quality and speed of fracture healing in osteoporotic fractures are crucial with regard to the outcome of patients. The question arises whether established antiosteoporotic drugs can further improve
A Nakajima, BA Rahn, C Li, CC Danielsen, D Seidlova-Wuttke, D. Seidlova-Wuttke, DN Kalu, E Tsiridis, E. K. Stuermer, E. Wenda, EK Stuermer, G Schmidmaier, GA Rodan, H Hatano, H Namkung-Matthai, HM Frost, HM Frost, J Aerssens, J Li, JG Blythe, K. H. Frosch, K. M. Stuermer, KM Stuermer, L Claes, LE Claes, M Miwa, M. Tezval, MC Faugerer, ME Bolander, NF Ray, P Aspenberg, P Klein, P Seebeck, RA Brand, RK Schenk, RM McCann, S. Sehmisch, T Kubo, T Ohishi, T. Rack, TJ Wronski, TJ Wronski, TJ Wronski, UT Iwaniec, W. Wuttke, WR Walsh, XJ Li, Y Cao, YL Hao, Z Peng   +49 more
core   +2 more sources

Fracture healing physiology and the quest for therapies for delayed healing and nonunion

Journal of Orthopaedic Research, 2016
Delayed healing and nonunion of fractures represent enormous burdens to patients and healthcare systems. There are currently no approved pharmacological agents for the treatment of established nonunions, or for the acceleration of fracture healing, and ...
P. Kostenuik, Faisal M Mirza
semanticscholar   +1 more source

Finite element simulations of smart fracture plates capable of cyclic shortening and lengthening: which stroke for which fracture?

Frontiers in Bioengineering and Biotechnology
Introduction: Bone healing can be improved by axial micromovement, as has been shown in animals and human patients with external fixators. In the development of smart fracture plates, the ideal amount of stroke for different fracture types in the ...
Michael Roland, Stefan Diebels, Kerstin Wickert, Tim Pohlemann, Bergita Ganse, Bergita Ganse   +5 more
doaj   +1 more source

Stem cell‐derived exosomes: A promising strategy for fracture healing

Cell Proliferation, 2017
To describe the biological characteristics of exosomes and to summarize the current status of stem cell‐derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed.
Zi-Chen Hao, Jun Lu, Shan-zheng Wang, Hao Wu, Yun-tong Zhang, Shuo-gui Xu   +5 more
semanticscholar   +1 more source

Predictive Model Development to Identify Failed Healing in Patients after Non-Union Fracture Surgery [PDF]

2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando, FL, USA, 2024, pp. 1-4
Bone non-union is among the most severe complications associated with trauma surgery, occurring in 10-30% of cases after long bone fractures. Treating non-unions requires a high level of surgical expertise and often involves multiple revision surgeries, sometimes even leading to amputation.
arxiv   +1 more source

Nutritional Aspects of Bone Health and Fracture Healing

Journal of Osteoporosis, 2017
Introduction Fractures are quite common, especially among the elderly. However, they can increase in prevalence in younger ages too if the bone health is not good. This may happen as a result of bad nutrition.
Athanasios Karpouzos, E. Diamantis, Paraskevi Farmaki, S. Savvanis, T. Troupis   +4 more
semanticscholar   +1 more source

Computational Modeling of the Effects of Inflammatory Response and Granulation Tissue Properties on Human Bone Fracture Healing [PDF]

arXiv, 2018
Bone healing process includes four phases: inflammatory response, soft callus formation, hard callus development, and remodeling. Mechanobiological models have been used to investigate the role of various mechanical and biological factors on the bone healing.
arxiv  

On penalization in variational phase-field models of brittle fracture [PDF]

, 2018
Irreversible evolution is one of the central concepts as well as implementation challenges of both the variational approach to fracture by Francfort and Marigo (1998) and its regularized counterpart by Bourdin, Francfort and Marigo (2000, 2007 and 2008), which is commonly referred to as a phase-field model of brittle fracture.
arxiv   +1 more source

TRPV1 deletion impaired fracture healing and inhibited osteoclast and osteoblast differentiation

Scientific Reports, 2017
Fracture healing, in which osteoclasts and osteoblasts play important roles, has drawn much clinical attention. Osteoclast deficiency or decreased osteoblast activity will impair fracture healing.
Linhai He, Meng Liu, Yang He, E. Xiao, Lu Zhao, Ting Zhang, Hua-Qian Yang, Yi Zhang   +7 more
semanticscholar   +1 more source