Results 1 to 10 of about 82,324 (247)

PRMT6 inhibitors promote fracture healing by modulating osteoclast glucose metabolism. [PDF]

Front Immunol
IntroductionImpaired fracture healing remains a significant clinical challenge due to the complexity of the healing process. Osteoclasts, derived from monocytes, are pivotal in bone tissue reconstruction, yet no effective clinical tools exist to promote ...
Wu N, Wang R, Nian S, Zhang H, Zhou P, Tang H.   +5 more
europepmc   +2 more sources

Gait Analysis to Monitor Fracture Healing of the Lower Leg

Bioengineering, 2023
Fracture healing is typically monitored by infrequent radiographs. Radiographs come at the cost of radiation exposure and reflect fracture healing with a time lag due to delayed fracture mineralization following increases in stiffness.
Elke Warmerdam, Marcel Orth, Tim Pohlemann, Bergita Ganse   +3 more
doaj   +1 more source

Joint Cartilage in Long-Duration Spaceflight

Biomedicines, 2022
This review summarizes the current literature available on joint cartilage alterations in long-duration spaceflight. Evidence from spaceflight participants is currently limited to serum biomarker data in only a few astronauts.
Bergita Ganse, Magali Cucchiarini, Henning Madry   +2 more
doaj   +1 more source

Simulation-based prediction of bone healing and treatment recommendations for lower leg fractures: Effects of motion, weight-bearing and fibular mechanics

Frontiers in Bioengineering and Biotechnology, 2023
Despite recent experimental and clinical progress in the treatment of tibial and fibular fractures, in clinical practice rates of delayed bone healing and non-union remain high.
Marcel Orth, Bergita Ganse, Bergita Ganse, Annchristin Andres, Kerstin Wickert, Elke Warmerdam, Max Müller, Stefan Diebels, Michael Roland, Tim Pohlemann   +9 more
doaj   +1 more source

Effects of age, body height, body weight, body mass index and handgrip strength on the trajectory of the plantar pressure stance-phase curve of the gait cycle

Frontiers in Bioengineering and Biotechnology, 2023
The analysis of gait patterns and plantar pressure distributions via insoles is increasingly used to monitor patients and treatment progress, such as recovery after surgeries.
Christian Wolff, Patrick Steinheimer, Elke Warmerdam, Tim Dahmen, Philipp Slusallek, Christian Schlinkmann, Fei Chen, Marcel Orth, Tim Pohlemann, Bergita Ganse, Bergita Ganse   +10 more
doaj   +1 more source

A Deep Learning Approach for Gait Event Detection from a Single Shank-Worn IMU: Validation in Healthy and Neurological Cohorts

Sensors, 2022
Many algorithms use 3D accelerometer and/or gyroscope data from inertial measurement unit (IMU) sensors to detect gait events (i.e., initial and final foot contact).
Robbin Romijnders, Elke Warmerdam, Clint Hansen, Gerhard Schmidt, Walter Maetzler   +4 more
doaj   +1 more source

The biology of fracture healing [PDF]

Injury, 2011
The biology of fracture healing is a complex biological process that follows specific regenerative patterns and involves changes in the expression of several thousand genes. Although there is still much to be learned to fully comprehend the pathways of bone regeneration, the over-all pathways of both the anatomical and biochemical events have been ...
Richard Marsell, Thomas A. Einhorn
openaire   +3 more sources

Single-Cell RNA Sequencing Reveals B Cells Are Important Regulators in Fracture Healing

Frontiers in Endocrinology, 2021
The bone marrow microenvironment is composed primarily of immune and stromal cells that play important roles in fracture healing. Although immune cells have been identified in mouse bone marrow, variations in their numbers and type during the fracture ...
Hao Zhang, Renkai Wang, Renkai Wang, Guangchao Wang, Bo Zhang, Chao Wang, Di Li, Chen Ding, Qiang Wei, Zhenyu Fan, Hao Tang, Fang Ji, Fang Ji   +12 more
doaj   +1 more source

Dynamization of the plate in treating nonunion of the tibial fracture: Case report

Journal of Orthopaedic Reports, 2023
Background: Plate osteosynthesis for the tibial fracture is one of the alternative treatments with satisfactory outcomes. Appropriate surgical techniques, including an open or minimally invasive approach, absolute or relative stability regarding fracture
Chittawee Jiamton, Pongsakorn Rungchamrussopa, Pariwat Taweekitikul, Techit Leelasestaporn, Theerachai Apivatthakakul   +4 more
doaj   +1 more source

Research progress in the roles of Notch signaling pathway during fracture healing

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur.
GUO Liqiang, ZHAO Shitian, SHU Bing
doaj   +1 more source