Results 31 to 40 of about 1,759,920 (268)

Impact of osteoporosis and osteoporosis medications on fracture healing: a narrative review [PDF]

open access: yes
UNLABELLED Antiresorptive medications do not negatively affect fracture healing in humans. Teriparatide may decrease time to fracture healing. Romosozumab has not shown a beneficial effect on human fracture healing.
Akesson, K E   +17 more
core   +4 more sources

Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels [PDF]

open access: yes, 2019
Macrophages are essential players in the process of fracture healing, acting by remodeling of the extracellular matrix and enabling vascularization. Whilst activated macrophages of M1-like phenotype are present in the initial pro-inflammatory phase of ...
Aulich, Linus   +11 more
core   +1 more source

The role of neurohumoral modulation in fracture healing:lifting a tip of the veil [PDF]

open access: yes, 2020
The process of fracture healing is an extremely complex process in which an immense amount of biological factors from the musculoskeletal-, neurological-, vascular- and immune-system interact with each other.
Hofman, Martijn
core   +2 more sources

Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover.

open access: yesEuropean Cells & Materials, 2018
Calcium and vitamin D are essential for maintaining bone health. Therefore, deficiencies in calcium and vitamin D are major risk factors for osteoporosis development.
V. Fischer   +3 more
semanticscholar   +1 more source

Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response [PDF]

open access: yes, 2015
The mechanism by which trauma initiates healing remains unclear. Precise understanding of these events may define interventions for accelerating healing that could be translated to the clinical arena.
Adel Ersek   +21 more
core   +1 more source

Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2019
Significance Our results show that one single systemic administration of the β-adrenoreceptor blocker propranolol prior to femur osteotomy in psychosocially stressed mice prevents stress-induced bone marrow mobilization of neutrophils and their ...
M. Haffner-Luntzer   +10 more
semanticscholar   +1 more source

Hydrogel delivery of lysostaphin eliminates orthopedic implant infection by Staphylococcus aureus and supports fracture healing

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2018
Significance Orthopedic implant infections require long-term antibiotic therapy and surgical debridement to successfully retain the implant; however, therapeutic failure can lead to implant removal.
Christopher T. Johnson   +7 more
semanticscholar   +1 more source

The interplay between tissue healing and bone remodeling around immediately loaded tooth replacement implants [PDF]

open access: yes, 2019
Long-term bone healing/adaptation after a dental implant treatment starts with diffusion of mesenchymal stem cells to the fracture callus and their subsequent differentiation. The healing phase is followed by the bone-remodeling phase. In this work, a mechano-regulatory cellular differentiation model was used to simulate tissue healing around an ...
arxiv   +1 more source

Failure mechanisms of single-crystal silicon electrodes in lithium-ion batteries [PDF]

open access: yesNature Communications, vol. 7, June 14, 2016, pp. 11886, 2016
Long-term durability is a major obstacle limiting the widespread use of lithium ion batteries (LIBs) in heavy-duty applications and others demanding extended lifetime. As one of the root causes of degradation and failure of battery performance, the electrode failure mechanisms are still unknown.
arxiv   +1 more source

Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma

open access: yesNaunyn-Schmiedeberg's Archives of Pharmacology, 2018
Patients with multiple injuries frequently suffer bone fractures and are at high risk to develop fracture healing complications. Because of its key role both in systemic posttraumatic inflammation and fracture healing, the pleiotropic cytokine ...
Kathrin Kaiser   +8 more
semanticscholar   +1 more source

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