Dysfunctional stem and progenitor cells impair fracture healing with age [PDF]
, 2019 Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies ...
Clauss, Matthias +12 more
core +1 more source
Development of a Step Counting Algorithm Using the Ambulatory Tibia Load Analysis System for Tibia Fracture Patients [PDF]
, 2018 Introduction: Ambulation can be used to monitor the healing of lower extremity fractures. However, the ambulatory behavior of tibia fracture patients remains unknown due to an inability to continuously quantify ambulation outside of the clinic.
Ackerman, Matt +7 more
core +2 more sources
Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy [PDF]
, 2020 Purpose: The classic fracture model, described by Bonnarens and Einhorn in 1984, enlists a blunt guillotine to generate a closed fracture in a pre-stabilized rodent femur.
Akkus, O. +6 more
core +1 more source
Early pH Changes in Musculoskeletal Tissues upon Injury-Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH [PDF]
, 2020 Local pH is stated to acidify after bone fracture. However, the time course and degree of acidification remain unknown. Whether the acidification pattern within a fracture hematoma is applicable to adjacent muscle hematoma or is exclusive to this ...
Berkmann, Julia C. +8 more
core +2 more sources
Properties of commonly used calcium phosphate cements in trauma and orthopaedic surgery [PDF]
, 2013 Introduction Half of the population sustains at least one fracture during their lifetime, and the majority of these fractures heal successfully.
Kops, N. (Nicole) +5 more
core +3 more sources
Clinical and Translational Medicine, 2023 Background Approximately 10% of all bone fractures result in delayed fracture healing or non‐union; thus, the identification of biomarkers and prognostic factors is of great clinical interest. MicroRNAs (miRNAs) are known to be involved in the regulation
Franziska Lioba Breulmann +6 more
doaj +1 more source
Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels [PDF]
, 2019 Macrophages are essential players in the process of fracture healing, acting by remodeling of the extracellular matrix and enabling vascularization. Whilst activated macrophages of M1-like phenotype are present in the initial pro-inflammatory phase of ...
Aulich, Linus +11 more
core +1 more source
Near-Infrared Spectroscopy Allows for Monitoring of Bone Fracture Healing via Changes in Oxygenation
Journal of Functional BiomaterialsBone fractures are associated with hypoxia, but no longitudinal studies of perfusion measurements in human patients have been reported despite the clinical and research potential.
Cedric Nowicki, Bergita Ganse
doaj +1 more source
Genetic polymorphisms of NOS2 and predisposition to fracture non-union: A case control study based on Han Chinese population. [PDF]
PLoS ONE, 2018 A non-union, especially atrophic non-unions, is a permanent failure of healing following a fracture and can be difficult to treat. Approximately 5-10% of fractures will result in a non-union during the healing process.
Wei Huang +5 more
doaj +1 more source
Frontiers in Digital HealthBackgroundGait can be continuously monitored via vertical ground reaction force (VGRF) and centre of pressure (COP) measurement with pressure-sensing insoles.
Elke Warmerdam +6 more
doaj +1 more source