Results 121 to 130 of about 172,523 (297)
Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges
Advanced Genetics, EarlyView.This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley +1 more source
A Quantitative ELISA Assay for the Fragile X Mental Retardation 1 Protein [PDF]
The Journal of Molecular Diagnostics, 2009 Non-coding (CGG-repeat) expansions in the fragile X mental retardation 1 (FMR1) gene result in a spectrum of disorders involving altered neurodevelopment (fragile X syndrome), neurodegeneration (late-onset fragile X-associated tremor/ataxia syndrome), or primary ovarian insufficiency. While reliable and quantitative assays for the number of CGG repeats
Danh V. Nguyen +7 more
openaire +3 more sources
Observation of Fragile-to-Strong Dynamic Crossover in Protein Hydration Water [PDF]
, 2006 At low temperatures proteins exist in a glassy state, a state which has no conformational flexibility and shows no biological functions. In a hydrated protein, at and above 220 K, this flexibility is restored and the protein is able to sample more conformational sub-states, thus becomes biologically functional. This 'dynamical' transition of protein is
arxiv +1 more source
Glass transition theory based on stress relaxation [PDF]
Journal of Physics: Condensed Matter 18, L251 (2006), 2005 We propose that an onset of glass transition can be defined as the point at which a supercooled liquid acquires the stress relaxation mechanism of a solid glass. We translate this condition into the rate equation for local relaxation events. This equation simultaneously gives two main signatures of glass transition, stretched-exponential relaxation and
arxiv +1 more source
Understanding the Molecular Basis of Fragile X Syndrome Using Differentiated Mesenchymal Stem Cells [PDF]
, 2022 Objectives Fragile X syndrome (FXS) has been known as the most common cause of inherited intellectual disability and autism. This disease results from the loss of fragile X mental retardation protein expression due to the expansion of CGG repeats located
Fazeli, Zahra +3 more
core +2 more sources
Medicinal Research Reviews, EarlyView.ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar +4 more
wiley +1 more source
The Fragile X Mental Retardation Protein in Circadian Rhythmicity and Memory Consolidation [PDF]
Molecular Neurobiology, 2009 The control of new protein synthesis provides a means to locally regulate the availability of synaptic components necessary for dynamic neuronal processes. The fragile X mental retardation protein (FMRP), an RNA-binding translational regulator, is a key player mediating appropriate synaptic protein synthesis in response to neuronal activity levels ...
Kendal Broadie, Cheryl L Gatto
openaire +3 more sources
Hair root FMRP expression for screening of fragile X full mutation females [PDF]
Universa Medicina, 2011 The fragile X syndrome is the most common form of inherited mental retardation in humans, caused by an expansion of the cytosine-guanine-guanine (CGG) repeat in the fragile X mental retardation 1 (FMR1) gene located on the X chromosome.
Lantip Rujito +5 more
doaj
Frontiers in Synaptic Neuroscience, 2018 Dopamine receptors and related signaling pathways have long been implicated in pathophysiology and treatment of mental illnesses, including schizophrenia and bipolar disorder.
Jivan Khlghatyan +3 more
doaj +1 more source
The molecular basis of the Fragile X syndrome
Journal of Experimental and Molecular Biology, 2023 This analysis aimed to clarify the molecular basis of fragile X syndrome and explain the role of genetic material in the genetic disease's development and treatment. Fragile X syndrome is an X-linked mutation inheritance disorder.
Harem Othman smail
doaj +1 more source