Results 71 to 80 of about 16,590 (205)
Communications Biology, 2021 Shen et al. propose a mechanism for the metastasis of hepatocellular carcinoma (HCC) cells through the localization and translation modulation of the STAT3 oncogene by fragile X mental retardation protein (FMRP).
Zhifa Shen +10 more
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The molecular basis of the Fragile X syndrome
Journal of Experimental and Molecular Biology, 2023 This analysis aimed to clarify the molecular basis of fragile X syndrome and explain the role of genetic material in the genetic disease's development and treatment. Fragile X syndrome is an X-linked mutation inheritance disorder.
Harem Othman smail
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Fragile X-Associated Neuropsychiatric Disorders (FXAND)
Frontiers in Psychiatry, 2018 Fragile X syndrome (FXS) is caused by the full mutation (>200 CGG repeats) in the Fragile X Mental Retardation 1 (FMR1) gene. It is the most common inherited cause of intellectual disability (ID) and autism.
Randi J. Hagerman +11 more
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A Guide to Machine Learning Epistemic Ignorance, Hidden Paradoxes, and Other Tensions
WIREs Data Mining and Knowledge Discovery, Volume 15, Issue 3, September 2025.ABSTRACT Machine learning (ML) has rapidly scaled in capacity and complexity, yet blind spots persist beneath its high performance façade. In order to shed more light on this argument, this paper presents a curated catalogue of 175 unconventional concepts, each capturing a paradox, tension, or overlooked risk in modern ML practice.
M. Z. Naser
wiley +1 more source
Conformational-Dependent and Independent RNA Binding to the Fragile X Mental Retardation Protein
Journal of Nucleic Acids, 2011 The interaction between the fragile X mental retardation protein (FMRP) and BC1 RNA has been the subject of controversy. We probed the parameters of RNA binding to FMRP in several ways. Nondenaturing agarose gel analysis showed that BC1 RNA transcripts
Xin Yan, Robert B. Denman
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Deep developmental phenotyping in children with tuberous sclerosis complex, with and without autism
Developmental Medicine &Child Neurology, Volume 67, Issue 9, Page 1165-1175, September 2025.Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16312 This original article is commented by Bonemazzi on pages 1113–1114 of this issue. Abstract Aim To characterize autism and co‐occurring tuberous sclerosis‐associated neuropsychiatric disorders (TAND) in children with tuberous sclerosis complex (TSC), addressing evidence gaps ...
Rebecca A. Mitchell +4 more
wiley +1 more source
Nature Communications, 2016 Alcohol is thought to lead to neuroadaptive changes, although the underlying molecular mechanisms are unclear. Here, the authors find ethanol treatment alters GABAB-receptor expression via fragile-X mental retardation protein in mice, leading to ...
Sarah A. Wolfe +10 more
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Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, Volume 12, Issue 29, August 7, 2025.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice
Neurobiology of Disease, 2008 Lack of fragile X mental retardation protein (FMRP) causes Fragile X Syndrome, the most common form of inherited mental retardation. FMRP is an RNA-binding protein and is a component of messenger ribonucleoprotein complexes, associated with brain ...
Femke M.S. de Vrij +7 more
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Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, Volume 12, Issue 29, August 7, 2025.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source