Results 51 to 60 of about 142,756 (290)
Systematic Study of the Failure of a Light-Frame Wood Roof in a Tornado
Buildings, 2012 Tornadoes are a particularly devastating natural hazard that affect communities across the United States, particularly the Midwest and South. They are unique from an engineering point-of-view due to their very low probability of occurrence but often ...
Christine Standohar-Alfano +3 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Correction to: Revision of the 1994 World Health Organization T-score definition of osteoporosis for use in older East Asian women and men to reconcile it with their lifetime risk of fragility fracture [PDF]
, 2023 Yì Wáng +10 more
openalex +1 more source
Damage assessment, fragility, and vulnerability analysis of reinforced concrete building
Građevinar, 2023 In addition to a concise literature review, this study presents a comparative analysis of reinforced concrete (RC) buildings through damage index (DI) analysis using different methodologies.
Radomir Folić +3 more
doaj +1 more source
Formes d'appréhension des fragilités matérielles
Revue d'anthropologie des connaissances, 2023 During the Fête des Vignerons, a centuries-old cultural event repeated every 20 to 25 years, many materials and technologies are tested and worked on to be integrated as components of a large-scale stage performance.
Dominique Vinck +2 more
doaj +1 more source
Fragile male, not fragile-X [PDF]
Advances in Psychiatric Treatment, 2008 No doubt the fragile-X chromosome plays a small part in male disadvantage, but the point made in my review ([Kraemer, 2000][1]), referred to by [Branney & White (2008)][2], is that the male is biologically less resilient.
openaire +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
The third space between land and water
Techne, 2018 The essay concentrates on the topic of water as a significant presence of natural and urban landscapes starting from its “mutable” and “dynamic” characteristic assumed as a crucial moment in the search for technological solutions regarding the “resilient
Marina Tornatora
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source