Results 51 to 60 of about 77,385 (311)

Genetic analysis of fragile X-syndrome.

Indian journal of medical sciences, 2001
Fragile X-syndrome is the most common inherited cause of mental retardation. The key clinical features of the fragile X-syndrome in males are mental retardation, a long face with large everted ears and large testes. The disorder is associated with a visible fragile site at Xq27.3 at FMR-1 loucs with the amplification of (CGC) n repeat sequence.
, Badaruddoza, G G, Shadab, M, Afzal, M D, Ahmad   +3 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Seismic Fragility Analysis of Existing Old Newari Brick Masonry Building in Pokhara Valley

Structural Mechanics of Engineering Constructions and Buildings
Most of the building stock in Nepal is based on masonry construction, which includes monumental, administrative, and residential structures. These structures are vulnerable during earthquakes, as evidenced by the massive structural damage, loss of human ...
Krishna Chapagain, Hemchandra Chaulagain
doaj   +1 more source

Stochastic Vulnerability Assessment of Masonry Structures: Concepts, Modeling and Restoration Aspects

Applied Sciences, 2019
A methodology aiming to predict the vulnerability of masonry structures under seismic action is presented herein. Masonry structures, among which many are cultural heritage assets, present high vulnerability under earthquake.
Panagiotis G. Asteris, Antonia Moropoulou, Athanasia D. Skentou, Maria Apostolopoulou, Amin Mohebkhah, Liborio Cavaleri, Hugo Rodrigues, Humberto Varum   +7 more
doaj   +1 more source

Seismic fragility analysis using stochastic polynomial chaos expansions

Probabilistic Engineering Mechanics, 2023
Within the performance-based earthquake engineering (PBEE) framework, the fragility model plays a pivotal role. Such a model represents the probability that the engineering demand parameter (EDP) exceeds a certain safety threshold given a set of selected intensity measures (IMs) that characterize the earthquake load.
Zhu X., Broccardo M., Sudret B.
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Fragility Analysis of Power Transmission Tower Subjected to Wind–Sand Loads

Energies
With the increasing construction of power transmission towers in desert regions for the transportation of wind or solar energy, structural safety under wind and sand loads has become critical.
Xiaoqian Ma, Jun Lu, Benliang Li, Weiguang Tian, Yaxiao Zhang, Peng Zhang   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Longitudinal seismic fragility analysis of utility tunnel structures based on IDA method

Yantu gongcheng xuebao
This study aims to propose a fragility analysis method for evaluating the longitudinal seismic performance of long-line utility tunnels based on nonlinear incremental dynamic analysis (IDA).
LI Jinqiang , ZHONG Zilan , SHEN Jiaxu , ZHANG Bu , ZHANG Yabo , DU Xiuli
doaj   +1 more source