Results 61 to 70 of about 2,213,618 (351)

Uncertainty and Quality rating in Analytical Vulnerability Assessment [PDF]

, 2014
Fragility curves represent a major component of seismic risk and vulnerability assessment of buildings and infrastructure facilities. A recently conducted extensive literature review under the framework of developing the “GEM Guide for Selecting of ...
D'Ayala, D, Ioannou, I, Lang, D, Meslem, A, Rossetto, T   +4 more
core  

Probing equilibrium glass flow up to exapoise viscosities [PDF]

, 2015
Glasses are out-of-equilibrium systems aging under the crystallization threat. During ordinary glass formation, the atomic diffusion slows down rendering its experimental investigation impractically long, to the extent that a timescale divergence is ...
Cerullo, G., Ferrante, C., Pogna, E. A. A., Rodríguez-Tinoco, C., Rodríguez-Viejo, J., Scopigno, T.   +5 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Mechanical behavior of osteoporotic bone at sub-lamellar length scales [PDF]

, 2015
Osteoporosis is a disease known to promote bone fragility but the effect on the mechanical properties of bone material, which is independent of geometric effects, is particularly unclear.
Anna eShipov, Asa eBarber, Asa eBarber, Ines eJimenez-Palomar, Ron eShahar   +4 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Stochastic approach for analytical fragility curves

KSCE Journal of Civil Engineering, 2008
One of the main problems is the assessment of “residual reliability” or “vulnerability” of a single existing structure, or of a given class of similar structures, against seismic actions. The fragility curves describe the probability of a structure to suffer a given damage level when it is subject to a given seismic excitation level. This research work
MARANO, Giuseppe Carlo, GRECO, Rita, MEZZINA M.   +2 more
openaire   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Thermophysical properties of a Cu46Zr42Al7Y5 bulk metallic glass-forming liquid [PDF]

, 2006
The thermophysical properties, including the specific volume V, the surface tension sigma, and the viscosity eta, of a Cu46Zr42Al7Y5 bulk metallic glass in the molten state were investigated using a containerless high-temperature high-vacuum ...
Choo, H., Fan, G. J., Johnson, W. L., Li, J. J. Z., Liaw, P. K., Qiao, D. C., Rhim, Won-Kyu   +6 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Mechanical-Analytical Soil-Dependent Fragility Curves of Existing RC Frames with Column-Driven Failures

Buildings, 2021
In seismic risk estimation, among the different types of fragility curves used (judgement-based, mechanical, empirical/observational, hybrid), the mechanical ones have the twofold advantage of allowing a better control over the basic parameters and of ...
Raihan Rahmat Rabi, Vincenzo Bianco, Giorgio Monti   +2 more
doaj   +1 more source