Results 61 to 70 of about 54,055 (308)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Buildings, 2021 In seismic risk estimation, among the different types of fragility curves used (judgement-based, mechanical, empirical/observational, hybrid), the mechanical ones have the twofold advantage of allowing a better control over the basic parameters and of ...
Raihan Rahmat Rabi +2 more
doaj +1 more source
Probing equilibrium glass flow up to exapoise viscosities [PDF]
, 2015 Glasses are out-of-equilibrium systems aging under the crystallization threat. During ordinary glass formation, the atomic diffusion slows down rendering its experimental investigation impractically long, to the extent that a timescale divergence is ...
Cerullo, G. +5 more
core +2 more sources
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Fragility and Vulnerability Analysis of an RC Building with the Application of Nonlinear Analysis
Buildings, 2021 In this paper, the seismic response of a five-story reinforced concrete (RC) frame system building is analysed through fragility analysis. The structure is designed in accordance with structural Eurocodes EN1990, EN1991, EN1992 and EN1998, as a high ...
Radomir Folić, Miloš Čokić
doaj +1 more source
An efficient methodology to estimate probabilistic seismic damage curves [PDF]
, 2019 The incremental dynamic analysis (IDA) is a powerful methodology that can be easily extended for calculating probabilistic seismic damage curves. These curves are metadata to assess the seismic risk of structures.
Barbat Barbat, Horia Alejandro +3 more
core +2 more sources
Empirical fragility curves for Peruvian school buildings [PDF]
WIT Transactions on The Built Environment, Vol 93, 2007 This paper describes an estimation of economic losses in Peruvian educational buildings for different levels of seismic action. Opinions of experts were processed to generate seismic intensity versus damage relationships. Economic losses were then expressed through fragility curves and damage matrices. For frequent earthquakes (50-year return period) a
A. Muñoz +3 more
openaire +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Applied Sciences, 2020 Fragility curves are essential tools to quantitatively assess the physical vulnerability of structures and infrastructures at risk for a given seismic hazard.
Angelo Anelli, Federico Mori, Marco Vona
doaj +1 more source
Mechanical behavior of osteoporotic bone at sub-lamellar length scales [PDF]
, 2015 Osteoporosis is a disease known to promote bone fragility but the effect on the mechanical properties of bone material, which is independent of geometric effects, is particularly unclear.
Anna eShipov +4 more
core +2 more sources