Results 101 to 110 of about 197,879 (225)

Unveiling Salt Tolerance Mechanisms in Plants: Integrating the KANMB Machine Learning Model With Metabolomic and Transcriptomic Analysis

Advanced Science, EarlyView.
Salt stress endangers coastal cereal crops, requiring resilient crop solutions. This study employs machine learning (KANMB) to analyze multi‐omics data from halophyte Spartina alterniflora, revealing 226 salt‐stress biomarkers and linking them to tolerance pathways. The MYB gene SaMYB35 regulates flavonoid biosynthesis under salinity.
Shoukun Chen, Hao Zhang, Shuqiang Gao, Kunhui He, Tingxi Yu, Shang Gao, Jiankang Wang, Huihui Li   +7 more
wiley   +1 more source

Safety and Efficacy of Avaren-Fc Lectibody Targeting HCV High-Mannose Glycans in a Human Liver Chimeric Mouse ModelSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Infection with hepatitis C virus (HCV) remains a major cause of morbidity and mortality worldwide despite the recent advent of highly effective direct-acting antivirals.
Matthew Dent, Krystal Hamorsky, Thibaut Vausselin, Jean Dubuisson, Yoshinari Miyata, Yoshio Morikawa, Nobuyuki Matoba   +6 more
doaj  

Smart Organic–Inorganic Copolymer Nanoparticles Distinguish Between Microglia and Cancer Cells for Synergistic Immunotherapy in Glioma

Advanced Science, EarlyView.
The tumor microenvironment‐responsive nanoagonists are developed using an organic–inorganic copolymer composed of the polymer (PC6AB) and manganous phosphate ionic oligomers (MnP). PC6AB with membranolytic activity selectively interacts with tumor cell membranes to induce immunogenic cell death, while MnP activates the STING pathway in immune cells ...
Shiming Zhang, Kun Shang, Lidong Gong, Qian Xie, Jianfei Sun, Meng Xu, Xunbin Wei, Zhaoheng Xie, Xinyu Liu, Hao Tang, Zhengren Xu, Wei Wang, Haihua Xiao, Zhiqiang Lin, Hongbin Han   +14 more
wiley   +1 more source

Super-Jeans fragmentation in massive star-forming regions revealed by triangulation analysis [PDF]

arXiv
Understanding the fragmentation of the gas cloud and the formation of massive stars remains one of the most challenging questions of modern astrophysical research. Either the gas fragmentation in a Jeans-like fashion, after which the fragments grow through accretion, or the fragmentation length is larger than the Jeans length from the start.
arxiv  

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Enhanced Reaction Kinetics in Sodium‐Ion Batteries Achieved by 3D Heterostructure CoS2/CoS with Self‐Induced Internal Electric Field

Advanced Science, EarlyView.
A novel HC@CoS2/CoS/NC composite with optimized heterointerfaces is successfully synthesized as an ultrastable and fast‐charging anode material for SIBs. This composite features a 3D architecture, characterized by highly dispersed CoS2/CoS/NC nanoparticles embedded within honeycomb carbon nanosheets.
Jin Liang, Jiawen Sun, Xin Cao, Xiaoshan Li, Xiaoyi Chen, Ruizhe Xing, Jie Kong   +6 more
wiley   +1 more source

Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca, Andrea Angeli, Federico Ricci, Claudiu T. Supuran, Rosaria Gitto   +4 more
wiley   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

Advanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, Asmaa Mohamed Ismail, Millie Robinson, Teresa Dallinger, Claudia Gutfleisch, Jochen Kurz, Maytê Toledo, Jessica Dias da Silva Ferraz, Mohammad Tarek, Danilo Dias, Ricardo Sobhie Diaz, Mahmoud ElHefnawi, Mattia Forcato, Hugo P Monteiro, Marina Lusic, Iart Luca Shytaj, Andrea Savarino   +20 more
wiley   +1 more source

Unveiling the Over‐Lithiation Behavior of NCM523 Cathode Towards Long‐Life Anode‐Free Li Metal Batteries

Advanced Science, EarlyView.
A comprehensive investigation of the over‐lithiation behavior of Li1+xNi0.5Co0.2Mn0.3O2 (Li1+xNCM523) reveals a critical threshold at x = 0.7, beyond which the structural stability of the cathode deteriorates due to irreversible reduction of transition metal ions.
Ruimin Gao, Minzhi Zhan, Tingcan Li, Pei Xiong, Qian Zhang, Zhefeng Chen, Jike Wang, Xinping Ai, Feng Pan, Liumin Suo, Jiangfeng Qian   +10 more
wiley   +1 more source

Recent Advances in Enhancing the Sensitivity of Biosensors Based on Field Effect Transistors

Advanced Electronic Materials, EarlyView.
This paper discusses the methods to enhancing the detection sensitivity of biosensors in three aspects: overcoming the influence of Debye shielding effects, promoting the binding efficiency of analytes and transistor surface, and improving the structures of device.
Yuying Zhou, Tongshi Feng, Yao Li, Xiang Ao, Shengfa Liang, Xiaonan Yang, Lingfei Wang, Xiaoxin Xu, Wenchang Zhang   +8 more
wiley   +1 more source