Development Of Gene Deleted Recombinant Pseudorabies Virus [PDF]
, 2004 The glycoprotein E (gE) and thymidine kinase (TK) genes are virulence-associated genes of pseudorabies virus (PrV). The study conducted was to shut down the gE gene from an established local TK defective (TK¯) PrV strain (TK¯gE+PrV).
Alauddin, Zeenathul Nazariah
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Quality, Non-clinical and Clinical Considerations for Biosimilar Monoclonal Antibody Development: EU, WHO, USA, Canada, and BRICS-TM Regulatory Guidelines [PDF]
, 2018 Objective: The aim was to critically evaluate well-established regulatory agencies mAb biosimilar guidelines for development and marketing authorization about quality, efficacy and safety and compare to BRICS-TM regulations to identify challenges ...
Anvisa +20 more
core +5 more sources
Cell Calcification Models and Their Implications for Medicine and Biomaterial Research
Advanced Healthcare Materials, EarlyView.Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter +5 more
wiley +1 more source
Pharmacogenetics driving personalized medicine: Analysis of genetic polymorphisms related to breast cancer medications in Italian isolated populations [PDF]
, 2016 BACKGROUND: Breast cancer is the most common cancer in women characterized by a high variable clinical outcome among individuals treated with equivalent regimens and novel targeted therapies.
Bedognetti, Davide +4 more
core +5 more sources
Fc-engineered antibodies promote neutrophil-dependent control of Mycobacterium tuberculosis
Nature MicrobiologyMounting evidence indicates that antibodies can contribute towards control of tuberculosis (TB). However, the underlying mechanisms of humoral immune protection and whether antibodies can be exploited in therapeutic strategies to combat TB are relatively
Edward B. Irvine +16 more
semanticscholar +1 more source
Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Advanced Healthcare Materials, EarlyView.Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
wiley +1 more source
The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding. [PDF]
, 2019 In eukaryotic meiosis, generation of haploid gametes depends on the formation of inter-homolog crossovers, which enable the pairing, physical linkage, and eventual segregation of homologs in the meiosis I division.
Arora, Kanika, Corbett, Kevin D
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Hepatotoxicity Associated with the Use of Anti-TNF-α Agents [PDF]
, 2015 Medications to inhibit the actions of tumour necrosis factor alpha have revolutionized the treatment of several pro-inflammatory autoimmune conditions.
Bonacini, Maurizio +4 more
core +2 more sources
Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery
Advanced Healthcare Materials, EarlyView.This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo +3 more
wiley +1 more source
A Comparative Study Of Antibody Responses In Tst+ And Tst- Groups With Long Term Exposure To Mycobacterium Tuberculosis [PDF]
, 2017 Tuberkulosis (TB) merupakan penyakit yang disebar oleh Mycobacterium tuberculosis (MTB) melalui udara. Secara tradisinya T-sel diberikan penekanan yang utama dalam pengantaraan jangkitan MTB dengan sedikit penekanan diberikan kepada B-sel dan antibody
Chin, Siang Tean
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