Results 171 to 180 of about 197,879 (225)

Enhancing vaccine half-life as a novel strategy for improving immune response durability of subunit vaccines. [PDF]

PLoS Pathog
Shen Z, Li C, Song W, Liu L, Kong Y, Huang A, Bao Q, Ying T, Wu Y.   +8 more
europepmc   +1 more source

Recent Advances in Enzymes and Chemoenzymatic Synthesis of Tetrasaccharide Linkage Region of Proteoglycans

ChemBioChem, Accepted Article.
Proteoglycans (PGs) play roles in many important biological events including growth factor signaling, wound repair, blood coagulation, brain development, and neural stem cell migration. As the glycosaminoglycan chain of PGs is attached to the core protein through a tetrasaccharide linkage region, it is important to decipher the intricate control of the
Po-han Lin, Xuefei Huang
wiley   +1 more source

Intranasal administration of a panreactive influenza antibody reveals Fc-independent mode of protection. [PDF]

Sci Rep
Beukenhorst AL, Rice KL, Frallicciardi J, Koldijk MH, Boudreau CM, Crawford J, Cornelissen LAHM, da Costa KAS, de Jong BA, Fischinger S, Julg B, Klap JM, Koch CM, Magyarics Z, Mohamed FAN, Okonkwo V, Adams L, McCarthy CM, Ronsard L, Temperton N, Vietsch H, Wichapong K, Ziere B, Lingwood D, Goudsmit J.   +24 more
europepmc   +1 more source

Engineering and Structural Elucidation of a Sac7d‐Derived IgG Fc‐Specific Affitin and Its Application for the Light‐Controlled Affinity Purification of Antibodies

ChemBioChem, EarlyView.
An affitin derived from the Sac7d scaffold enables the light‐controlled affinity purification of antibodies under physiological conditions, thus overcoming limitations of protein A chromatography. X‐ray crystallographic analysis and affinity measurements reveal complex formation with Fc at the CH2/CH3 junction, similar to protein A/G and FnRn. Combined
Felix Veitl, Andreas Eichinger, Peter Mayrhofer, Markus R. Anneser, Mauricio Testanera, Kilian Rauscher, Matthias Lenz, Arne Skerra   +7 more
wiley   +1 more source

Preclinical B cell depletion and safety profile of a brain-shuttled crystallizable fragment-silenced CD20 antibody. [PDF]

Clin Transl Med
Schumacher VL, Pichereau S, Bessa J, Bachl J, Herter S, Weber FC, Auer J, Kipar A, Winter M, Stirn M, Otteneder MB, Brady K, Eichinger-Chapelon A, Roth A, Stokar-Regenscheit N, Clemann N, Seger S, Senn C, Hönig J, Jany C, Lenarda ED, Tissot AC, Klein C, von Büdingen HC, Mader R, Ullah M, Janssen N, Urich E.   +27 more
europepmc   +1 more source

The Molecular Toolbox for Linkage Type‐Specific Analysis of Ubiquitin Signaling

ChemBioChem, EarlyView.
Ubiquitin modifications regulate virtually all aspects of eukaryotic cell biology through an array of polyubiquitin chain signals that adopt distinct structures, enabling the individual polyubiquitin linkages to mediate specific functions in cells.
Julian Koch, Camilla Reiter Elbæk, Dominik Priesmann, Rune Busk Damgaard   +3 more
wiley   +1 more source

<i>Neospora caninum</i> as delivery vehicle for anti-PD-L1 scFv-Fc: A novel approach for cancer immunotherapy. [PDF]

Mol Ther Oncol
Riviere C, Aljieli M, Mévélec MN, Lantier L, Boursin F, Lajoie L, Ducournau C, Germon S, Moiré N, Dimier-Poisson I, Aubrey N, di Tommaso A.   +11 more
europepmc   +1 more source

Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele

Chronic Diseases and Translational Medicine, EarlyView.
Mechanism of action of monoclonal antibodies targeting Aβ in the treatment of AD. (A) Targets of various mAbs. (B) Mechanism of monoclonal antibody‐mediated clearance of Aβ. mAbs facilitate the clearance of Aβ by enhancing microglial‐mediated phagocytosis through the upregulation of TREM2 expression.
Valentinus Besin, Farizky Martriano Humardani, Fenny Lanawati Yudiarto, Paulus Anam Ong, Sulistyo Emantoko Dwi Putra, Ratih Asmana Ningrum   +5 more
wiley   +1 more source

Mechanochemical Synthesis of Pillar[5]arene‐based [c2]Daisy Chain Rotaxanes

ChemistryEurope, EarlyView.
[c2]Daisy chain rotaxanes have been prepared under solvent‐free mechanochemical conditions by acylation of pillar[5]arene derivatives bearing either a 11‐hydroxy‐undecyl or 11‐amino‐undecyl subunit. Concentration effects are clearly beneficial as daisy chain assemblies are effectively present in the solid state despite the very weak affinity of the ...
Boram Park, Iwona Nierengarten, Jean‐François Nierengarten   +2 more
wiley   +1 more source

Introduction of a Phosphine Group onto the Ferrocene Moiety in Ferrociphenol Opens Access to New Heterobimetallic Complexes with Anticancer Activity

ChemistryEurope, EarlyView.
Modification of the ferrociphenol structure by a phosphine moiety appended to the originally unsubstituted cyclopentadienyl ring of the ferrocene unit represents a new and useful modification of this potent anticancer agent and opens a way to the preparation of new biologically active derivatives (e.g., phosphonium salts) and, mainly, heterobimetallic ...
Magda Křelinová, Michèle Salmain, Petr Štěpnička, Ivana Císařová, Benoît Bertrand, Jiří Schulz   +5 more
wiley   +1 more source