Results 201 to 210 of about 7,556 (242)

Probing the Inhibitory Potential of Halogenated Symmetrical Formamidine Against MAO‐A and MAO‐B: Structural Elucidation, Molecular Dynamic Simulation and DFT Computational Studies

Chemistry &Biodiversity, EarlyView.
ABSTRACT A halogenated symmetrical formamidine, N,N′‐bis(3‐chloro‐4‐fluorophenyl)formamidine (FCF) was synthesized by the condensation reaction between triethyl orthoformate and 3‐chloro‐4‐fluoroaniline in 1:2 ratio. The compound FCF was characterized by FT‐IR, mass, NMR (1H and 13C) spectroscopic techniques and the purity was confirmed by elemental ...
Segun D. Oladipo, Robert C. Luckay, Samuel O. Olalekan, Abosede A. Badeji, Tunde L. Yusuf, Adesola A. Adeleke, Nonkosi Matinise   +6 more
wiley   +1 more source

Sample-sparing multiplexed antibody Fc biomarker discovery using a reconfigurable integrated microfluidic platform.

Lab Chip
Zhang H, Bhakta D, Saha A, Peddireddy SP, Bao S, Li L, Handali S, Secor WE, Fraga LAO, Fairley JK, Sarkar A.   +10 more
europepmc   +1 more source

Intranasal administration of a panreactive influenza antibody reveals Fc-independent mode of protection. [PDF]

Sci Rep
Beukenhorst AL, Rice KL, Frallicciardi J, Koldijk MH, Boudreau CM, Crawford J, Cornelissen LAHM, da Costa KAS, de Jong BA, Fischinger S, Julg B, Klap JM, Koch CM, Magyarics Z, Mohamed FAN, Okonkwo V, Adams L, McCarthy CM, Ronsard L, Temperton N, Vietsch H, Wichapong K, Ziere B, Lingwood D, Goudsmit J.   +24 more
europepmc   +1 more source

Boosting Antibiotic Efficacy of Azole Drugs against Methicillin‐Resistant Staphylococcus aureus by Coordination to Rhenium Carbonyl Complexes

ChemBioChem, Accepted Article.
In this study, a library of rhenium di‐ and tricarbonyl complexes featuring various antimicrobial azoles as monodentate ligands was synthesized and characterized. Their antimicrobial activity was evaluated against both methicillin‐sensitive (MSSA) and methicillin‐resistant (MRSA) Staphylococcus aureus, and selected compounds were also assessed for ...
Kevin Schindler, Gozde Demirci, Bettina Tran, Sara Nasiri Sovari, Youri Cortat, Nicolas F. Rosa De Sousa, Carola Velti, Baptiste Chapuis, Aurélien Crochet, Aleksandar Pavic, Jelena Djuris, Stefan Salentinig, Fabio Zobi   +12 more
wiley   +1 more source

Next-Generation Anti-TNFα Agents: The Example of Ozoralizumab. [PDF]

BioDrugs
Tsumoto K, Takeuchi T.
europepmc   +1 more source

Shifting the Substrate Scope of an Ene/Yne‐Reductase by Loop Engineering

ChemCatChem, EarlyView.
A flexible active‐site loop that is involved in shaping the substrate and product cleft as well as the active‐site pocket was identified for the MDR‐related ene/yne‐reductase CaeEnR1 from Cyclocybe aegerita. Double mutations of this loop showed an up to 20‐fold increase in conversion rates toward cinnamaldehyde‐like substrates and a 2‐fold increase in ...
Dominik Karrer, Erika Wedler, Carolin Mewe, Martin Gand, Marian Vogt, Lukas Korf, Lars‐Oliver Essen, Martin Rühl   +7 more
wiley   +1 more source

Preclinical B cell depletion and safety profile of a brain-shuttled crystallizable fragment-silenced CD20 antibody. [PDF]

Clin Transl Med
Schumacher VL, Pichereau S, Bessa J, Bachl J, Herter S, Weber FC, Auer J, Kipar A, Winter M, Stirn M, Otteneder MB, Brady K, Eichinger-Chapelon A, Roth A, Stokar-Regenscheit N, Clemann N, Seger S, Senn C, Hönig J, Jany C, Lenarda ED, Tissot AC, Klein C, von Büdingen HC, Mader R, Ullah M, Janssen N, Urich E.   +27 more
europepmc   +1 more source

Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele

Chronic Diseases and Translational Medicine, EarlyView.
Mechanism of action of monoclonal antibodies targeting Aβ in the treatment of AD. (A) Targets of various mAbs. (B) Mechanism of monoclonal antibody‐mediated clearance of Aβ. mAbs facilitate the clearance of Aβ by enhancing microglial‐mediated phagocytosis through the upregulation of TREM2 expression.
Valentinus Besin, Farizky Martriano Humardani, Fenny Lanawati Yudiarto, Paulus Anam Ong, Sulistyo Emantoko Dwi Putra, Ratih Asmana Ningrum   +5 more
wiley   +1 more source

A Novel Biosensor for the Early Detection of <i>Aethina tumida</i> via <i>Kodamaea ohmeri</i> in Honeybee Colonies. [PDF]

Insects
Ghisellini P, Garbati P, Pietropaoli M, Cersini A, Pietrella G, Rando C, Giacomelli L, Ottoboni S, Formato G, Eggenhöffner R.   +9 more
europepmc   +1 more source

Introduction of a Phosphine Group onto the Ferrocene Moiety in Ferrociphenol Opens Access to New Heterobimetallic Complexes with Anticancer Activity

ChemistryEurope, EarlyView.
Modification of the ferrociphenol structure by a phosphine moiety appended to the originally unsubstituted cyclopentadienyl ring of the ferrocene unit represents a new and useful modification of this potent anticancer agent and opens a way to the preparation of new biologically active derivatives (e.g., phosphonium salts) and, mainly, heterobimetallic ...
Magda Křelinová, Michèle Salmain, Petr Štěpnička, Ivana Císařová, Benoît Bertrand, Jiří Schulz   +5 more
wiley   +1 more source