Results 61 to 70 of about 121,959 (273)

Spinodal-assisted crystallization in polymer melts [PDF]

, 1998
Recent experiments in some polymer melts quenched below the melting temperature have reported spinodal kinetics in small-angle x-ray scattering before the emergence of a crystalline structure.
A. J. Ryan, G. Goldbeck-Wood, G. Strobl, I. I. Frenkel, J. Brandrup, J. D. Gunton, J. D. McCoy, J. W. Cahn, J. W. Martin, K. Kawasaki, L. D. Landau, L. R. Pratt, M. Cakmak, M. Dettenmaier, M. Imai, M. Imai, M. R. L. Evans, N. J. Terrill, N. J. Terrill, P. D. Olmsted, P. J. Flory, P. R. ten Wolde, S. Alexander, S. Harrington, T. A. Ezquerra, T. C. B. McLeish, T. Dehoff, T. Kanaya, W. C. K. Poon, W. C. K. Poon, W. C. K. Poon   +30 more
core   +2 more sources

Role of the Fc Region in the Vitreous Half-Life of Anti-VEGF Drugs.

Investigative Ophthalmology and Visual Science, 2017
Purpose To identify the role of the fragment crystallizable (Fc) region in determining intraocular protein drug pharmacokinetics. Methods We generated a new VEGF-Trap lacking the Fc region (FcfVEGF-Trap, MWt = 100 kDa) by replacing the Fc region of ...
Kwangsic Joo, S. Park, Yewon Choi, J. E. Lee, Y. M. Na, Hye kyoung Hong, K. Park, Ho Min Kim, J. Chung, S. Woo   +9 more
semanticscholar   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

A plant-biotechnology approach for producing highly potent anti-HIV antibodies for antiretroviral therapy consideration

Journal of Genetic Engineering and Biotechnology, 2021
Despite a reduction in global HIV prevalence the development of a pipeline of new therapeutics or pre-exposure prophylaxis to control the HIV/AIDS epidemic are of high priority.
Advaita Acarya Singh, Priyen Pillay, Lusisizwe Kwezi, Tsepo Lebiletsa Tsekoa   +3 more
doaj   +1 more source

Antibody degradation in tobacco plants: a predominantly apoplastic process. [PDF]

, 2011
BACKGROUND: Interest in using plants for production of recombinant proteins such as monoclonal antibodies is growing, but proteolytic degradation, leading to a loss of functionality and complications in downstream purification, is still a serious problem.
Drake, PM, Hehle, VK, Ma, JK, Paul, MJ, van Dolleweerd, CJ   +4 more
core   +2 more sources

Does the Fc Region Have a Role in the Ocular Half-life After Intravitreal Injection?

Investigative Ophthalmology and Visual Science, 2020
We have read with interest the article by Joo et al.1 entitled “Role of the Fc region in the vitreous half-life of antiVEGF drugs,” which concludes that the fragment crystallizable (Fc) region is a determinant of ocular pharmacokinetics (PK) following ...
A. Caruso, N. Mazer
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Natural Killer Cells in Antibody Independent and Antibody Dependent HIV Control

Frontiers in Immunology, 2022
Infection with the human immunodeficiency virus (HIV), when left untreated, typically leads to disease progression towards acquired immunodeficiency syndrome.
Nicole F. Bernard, Nicole F. Bernard, Nicole F. Bernard, Nicole F. Bernard, Sanket Kant, Sanket Kant, Sanket Kant, Zahra Kiani, Zahra Kiani, Zahra Kiani, Cécile Tremblay, Cécile Tremblay, Franck P. Dupuy, Franck P. Dupuy   +13 more
doaj   +1 more source

Immunity against fungal beta 1,3 glucan carbohydrate in the gastrointestinal tract [PDF]

, 2016
Inflammatory Bowel Disease (IBD) is a debilitating, life- long disease that affects about 1.4 millions Americans. Little is known about the pathogenesis of IBD and an effective cure still remains to be discovered.
Feliu, Marianela
core   +1 more source