Results 81 to 90 of about 1,654,002 (384)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Conservation strategies for endangered arable plant Euphorbia gaditana

Conservation Science and Practice, 2022
Fragmentation and habitat loss are considered among the most important threats to biodiversity. More precisely, transformation of natural habitats into farmlands has been identified as one of the primary causes of plant species extinction.
Sonia G. Rabasa, Rut Sánchez de Dios, Francisco José Cabezas Fuentes, María Beatriz Pías Couso, Felipe Domínguez Lozano   +4 more
doaj   +1 more source

Spin effects in the fragmentation of transversely polarized and unpolarized quarks [PDF]

, 2000
We study the fragmentation of a transversely polarized quark into a non collinear (k_T not= 0) spinless hadron and the fragmentation of an unpolarized quark into a non collinear transversely polarized spin 1/2 baryon. These nonperturbative properties are
Anselmino, M., Boer, D., D'Alesio, U., Murgia, F.   +3 more
core   +3 more sources

An index-based framework for assessing patterns and trends in river fragmentation and flow regulation by global dams at multiple scales

, 2017
The global number of dam constructions has increased dramatically over the past six decades and is forecast to continue to rise, particularly in less industrialized regions.
G. Grill, B. Lehner, A. E. Lumsdon, G. MacDonald, C. Zarfl, C. Reidy Liermann   +5 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Recent Progress on Perturbative QCD Fragmentation Functions [PDF]

, 1995
The recent development of perturbative QCD (PQCD) fragmentation functions has strong impact on quarkonium production. I shall summarize $B_c$ meson production based on these PQCD fragmentation functions, as well as, the highlights of some recent ...
Cheung, Kingman
core   +3 more sources

Noise in Coevolving Networks [PDF]

, 2015
Coupling dynamics of the states of the nodes of a network to the dynamics of the network topology leads to generic absorbing and fragmentation transitions.
Diakonova, Marina, Eguiluz, Victor M., Miguel, Maxi San   +2 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

MetFrag relaunched: incorporating strategies beyond in silico fragmentation

Journal of Cheminformatics, 2016
BackgroundThe in silico fragmenter MetFrag, launched in 2010, was one of the first approaches combining compound database searching and fragmentation prediction for small molecule identification from tandem mass spectrometry data.
Christoph Ruttkies, Emma L. Schymanski, Sebastian Wolf, J. Hollender, S. Neumann   +4 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source