Results 31 to 40 of about 164 (114)

Investigating the Protein Signature of Adamantinomatous Craniopharyngioma Pediatric Brain Tumor Tissue: Towards the Comprehension of Its Aggressive Behavior

Disease Markers, Volume 2019, Issue 1, 2019., 2019
Although histologically benign, adamantinomatous craniopharyngioma (AC) pediatric brain tumor is a locally aggressive disease that frequently determines symptoms and hormonal dysfunctions related to the mass effect on the surrounding structures. Another typical feature of this benign neoplasm is the presence of voluminous liquid cysts frequently ...
Claudia Martelli, Riccardo Serra, Ilaria Inserra, Diana Valeria Rossetti, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, Andrea Urbani, Gianpiero Tamburrini, Massimo Caldarelli, Luca Massimi, Claudia Desiderio, Sunil Hwang   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, Volume 20, Issue 3, Page 588-610, March 2026.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Review of Small Gauge Vitrectomy: Progress and Innovations

Journal of Ophthalmology, Volume 2017, Issue 1, 2017., 2017
Purpose. To summarise the surgical advances and evolution of small gauge vitrectomy and discuss its principles and application in modern vitreoretinal surgery. The advent of microincisional vitrectomy systems (MIVS) has created a paradigm shift away from twenty‐gauge vitrectomy systems, which have been the gold standard in the surgical management of ...
Shaheeda Mohamed, Carl Claes, Chi Wai Tsang, Ala Moshiri   +3 more
wiley   +1 more source

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models

PLOS Genetics, 2022
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood. We explored the roles of deoxyribonuclease 1 (DNASE1) and deoxyribonuclease 1-like 3 (DNASE1L3) in the fragmentation of ucfDNA using mouse models.
Meihui Chen, Rebecca W. Y. Chan, Peter P. H. Cheung, Meng Ni, Danny K. L. Wong, Ze Zhou, Mary-Jane L. Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O. Lui, W. K. Jacky Lam, Jeremy Y. C. Teoh, Chi-Fai Ng, Peiyong Jiang, K. C. Allen Chan, Rossa W. K. Chiu, Y. M. Dennis Lo   +18 more
openaire   +3 more sources

Early detection of ovarian cancer using cell-free DNA fragmentomes and protein biomarkers. [PDF]

Ovarian cancer is a leading cause of death for women worldwide in part due to ineffective screening methods. In this study, we used whole-genome cell-free DNA (cfDNA) fragmentome and protein biomarker (CA-125 and HE4) analyses to evaluate 591 women with ...
Adleff, Vilmos, Jung, Euihye, Lok, Christine, Bartolomucci, Adrianna, Andersen, Claus, Carvalho, Beatriz, Bruhm, Daniel, Dua, Renu, Noë, Michaël, Therkildsen, Christina, Vulpescu, Nicholas, Konecny, Gottfried, Sokoll, Lori, Annapragada, Akshaya, Mathios, Dimitrios, Scharpf, Robert, Cristiano, Stephen, Velculescu, Victor, Symecko, Heather, Canzoniero, Jenna, Short, Sarah, Drapkin, Ronny, Baylin, Stephen, Press, Michael, Slamon, Dennis, Domchek, Susan, Foda, Zachariah, Hruban, Carolyn, Meijer, Gerrit, van den Broek, Daan, Lof, Pien, Medina, Jamie, Niknafs, Noushin, Phallen, Jillian, Koul, Shashikant   +34 more
core   +1 more source

Clinical Application of Peripheral Blood Biomarkers for Solid Tumors

MedComm, Volume 7, Issue 3, March 2026.
Peripheral blood biomarkers provide a minimally invasive, dynamic, and potentially more accurate means to obtain a comprehensive tumor profile. Technologies for detecting them are advancing, and with the help of artificial intelligence, they are being used more and more often for cancer diagnosis, prognostic assessment, and therapeutic monitoring ...
Xinru Tu, Mengyan Tu, Junfen Xu
wiley   +1 more source

Detection of known gene fusions in cancer cell lines using whole-genome bisulfite sequencing data

Scientific Reports
Whole-genome bisulfite sequencing (WGBS) provides multiple molecular information layers including methylation, copy number variations (CNVs), single nucleotide variants (SNVs), and fragmentome patterns in cell-free DNA (cfDNA) while gene fusion detection
Taehoon Kim, Duhee Bang
doaj   +1 more source

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection [PDF]

Cell-free DNA analysis via methylation and fragmentation profiling has advanced minimally invasive cancer detection; however, broader application has been limited by small cohorts and inconsistent data processing.
Luo, Ping, Zadeh, Gelareh, De Carvalho, Daniel D., Mohanraj, Suluxan, Singhawansa, Althaf, Notta, Faiyaz, Hoffman, Michael M., Zeng, Yong, Fang, Yuanchang, Main, Sasha C., Awadalla, Philip, Lok, Benjamin H., Stutheit-Zhao, Eric Y., Znassi, Nadia, Chen, Kui, Sanz-Garcia, Enrique, Ghanekar, Anand, Abelman, Dor D., Cheng, Nicholas, Bell, Emma, Ye, Wenbin, Wilson, Samantha L., Wong, Derek, Kim, Raymond H., Pugh, Trevor J., He, Housheng Hansen, Bratman, Scott V., Lupien, Mathieu   +27 more
core   +1 more source

Cell‐free epigenomes enhanced fragmentomics‐based model for early detection of lung cancer

Clinical and Translational Medicine, Volume 15, Issue 2, February 2025.
Lung cancer‐related changes in fragmentomic features were unevenly distributed across the genome, showing significant enrichment in epigenetically regulated regions of specific genes. The cfDNA fragmentomics‐based model demonstrated superior detection capability, especially for early‐stage lung cancer.
Yadong Wang, Qiang Guo, Zhicheng Huang, Liyang Song, Fei Zhao, Tiantian Gu, Zhe Feng, Haibo Wang, Bowen Li, Daoyun Wang, Bin Zhou, Chao Guo, Yuan Xu, Yang Song, Zhibo Zheng, Zhongxing Bing, Haochen Li, Xiaoqing Yu, Ka Luk Fung, Heqing Xu, Jianhong Shi, Meng Chen, Shuai Hong, Haoxuan Jin, Shiyuan Tong, Sibo Zhu, Chen Zhu, Jinlei Song, Jing Liu, Shanqing Li, Hefei Li, Xueguang Sun, Naixin Liang   +32 more
wiley   +1 more source

Abstract Book for the 27th Congress of the European Hematology Association

, 2022
HemaSphere, Volume 6, Issue S3, Page 1-4130, June 2022.
wiley   +1 more source