Results 41 to 50 of about 13,382 (298)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Preparation and Property Study of Enzymatically Modified Octenyl Succinate Starch
Liang you shipin ke-jiOctenylsuccinic anhydride starch (OSAS) has high viscosity and low solubility in water, which often leads to low efficiency in the esterification reaction between starch and octenylsuccinic anhydride under alkaline conditions, and uneven distribution of ...
HU Zhong-shan +4 more
doaj +1 more source
Preparation and Characterization of Water-Based Nano-Perfumes
Nanomaterials, 2018 The application of nanoemulsions as a novel delivery system for lipophilic materials, such as essential oils, flavors, and fragrances is one of the growing technologies used in cosmetic, pharmaceutical, and food industries.
Małgorzata Miastkowska +3 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Analysis of hypersensitivity in fragrance series by patch testing
Indian Dermatology Online Journal, 2019 Introduction: Allergic contact dermatitis (ACD) is an inflammatory disorder, which occurs as a result of repeated contact with an allergen. Fragrances are the products obtained naturally or produced synthetically.
Mohan Kumar Periyasamy +2 more
doaj +1 more source
The gene for fragrance in rice [PDF]
Plant Biotechnology Journal, 2005 SummaryThe flavour or fragrance of basmati and jasmine rice is associated with the presence of 2‐acetyl‐1‐pyrroline. A recessive gene (fgr) on chromosome 8 of rice has been linked to this important trait. Here, we show that a gene with homology to the gene that encodes betaine aldehyde dehydrogenase (BAD) has significant polymorphisms in the coding ...
Bradbury, Louis M. T. +4 more
openaire +5 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2008 Contact allergy to fragrances is a common cause of contact dermatitis. As a screening tool for contact allergy to fragrances the fragrance mix I (FM I), which is part of the European standard series, and fragrance mix II (FM II) can be used.
Van Oosten, E.J. +2 more
core +1 more source