Results 41 to 50 of about 15,575 (291)

Enzyme structure correlates with variant effect predictability

Computational and Structural Biotechnology Journal
Protein engineering increasingly relies on machine learning models to computationally pre-screen promising novel candidates. Although machine learning approaches have proven effective, their performance on prospective screening data leaves room for ...
Floris van der Flier, Dave Estell, Sina Pricelius, Lydia Dankmeyer, Sander van Stigt Thans, Harm Mulder, Rei Otsuka, Frits Goedegebuur, Laurens Lammerts, Diego Staphorst, Aalt D.J. van Dijk, Dick de Ridder, Henning Redestig   +12 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effect of fragrance use on discrimination of individual body odor

Frontiers in Psychology, 2015
Previous research suggests that artificial fragrances may be chosen to complement or enhance an individual’s body odor, rather than simply masking it, and that this may create an odor blend with an emergent quality that is perceptually distinguishable ...
Caroline eAllen, Jan eHavlíček, S Craig eRoberts   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Preparation and Characterization of Water-Based Nano-Perfumes

Nanomaterials, 2018
The application of nanoemulsions as a novel delivery system for lipophilic materials, such as essential oils, flavors, and fragrances is one of the growing technologies used in cosmetic, pharmaceutical, and food industries.
Małgorzata Miastkowska, Elwira Lasoń, Elżbieta Sikora, Katarzyna Wolińska-Kennard   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Analysis of hypersensitivity in fragrance series by patch testing

Indian Dermatology Online Journal, 2019
Introduction: Allergic contact dermatitis (ACD) is an inflammatory disorder, which occurs as a result of repeated contact with an allergen. Fragrances are the products obtained naturally or produced synthetically.
Mohan Kumar Periyasamy, Shanmuga C Sekar, Reena Rai   +2 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Contact allergy to fragrances

, 2008
Contact allergy to fragrances is a common cause of contact dermatitis. As a screening tool for contact allergy to fragrances the fragrance mix I (FM I), which is part of the European standard series, and fragrance mix II (FM II) can be used.
Van Oosten, E.J., Coenraads, P.J., Schuttelaar, M.-L.A.; id_orcid   +2 more
core   +1 more source

POLYSENSITIZATION IN A PEDIATRIC PATIENT WITH SLIME DERMATITIS [PDF]

Journal of IMAB
Purpose: To present a pediatric case of hand dermatitis associated with homemade slime exposure and to analyze the factors contributing to polysensitization in children.
Bisera Kotevska Trifunova, Stefana Damevska, Biljana Ilkovska, Zdravka Demerdjieva   +3 more
doaj   +1 more source