Results 91 to 100 of about 6,408 (161)

A genome‐integrated CRISPR/Cas12a system enables efficient genetic engineering in Xenorhabdus budapestensis XBD8

New Plant Protection, Volume 3, Issue 2, June 2026.
We developed a genome‐integrated CRISPR/Cas12a system for Xenorhabdus budapestensis XBD8, which enables precise deletion or replacement of DNA fragments ranging from 379 to 45,168 bp, with a success rate exceeding 90%. Application of this tool for the dynamic regulation of fabclavine‐8 biosynthesis resulted in a 1.90‐fold increase in production ...
Wenfeng Gan, Jiaqi Duan, Changyan Yin, Liwen Zhang, Guangyue Li   +4 more
wiley   +1 more source

First molecular detection of Francisella tularensis in turtle (Testudo graeca) and ticks (Hyalomma aegyptium) in Northwest of Iran

International Journal for Parasitology: Parasites and Wildlife
Francisella tularensis, causative agent of tularemia, is a contagious zoonotic ailment. This study was aimed to molecularly detect F. tularensis in tortoise blood (n = 100) and ticks (n = 100) collected in the West Azerbaijan province, Iran suing a ...
Amir Tukmechi, Abdulghaffar Ownagh, Ahmad Enferadi, Peyman Khademi   +3 more
doaj   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Iron and Virulence in Francisella tularensis [PDF]

Frontiers in Cellular and Infection Microbiology, 2017
Francisella tularensis, the causative agent of tularemia, is a Gram-negative bacterium that infects a variety of cell types including macrophages, and propagates with great efficiency in the cytoplasm. Iron, essential for key enzymatic and redox reactions, is among the nutrients required to support this pathogenic lifestyle and the bacterium relies on ...
openaire   +2 more sources

Progress and Prospects of Rare Metal‐Based Electrochemiluminescence Sensors for Detection of Water Environmental Pollutants

Rare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Water pollution is becoming increasingly severe, posing a serious hazard to human health and ecological security. Therefore, it is necessary to develop rapid, sensitive, and universal analytical methods to detect residual pollutants in actual water.
Yi Xing, Ru Wu, Min Zhang, Faliang Cheng, Jun‐Jie Zhu   +4 more
wiley   +1 more source

Detection of Francisellaceae and the differentiation of main European F. tularensis ssp. holarctica strains (Clades) by new designed qPCR assays

BMC Microbiology
Background The zoonotic and highly infectious pathogen Francisella tularensis is the etiological agent of tularemia. Tularemia in humans is mainly caused by F. tularensis subspecies tularensis and holarctica, but Francisella species like F.
Kristin Köppen, Kerstin Rydzewski, Julia Zajac, Marwah Al-Senwi, Sema Evcimen, Darius Schulze, Daniela Jacob, Klaus Heuner   +7 more
doaj   +1 more source

Francisella tularensis in Rodents, China

, 2006
A total of 420 rodents in China were examined for Francisella tularensis by polymerase chain reaction. The infection rates were 4.76% in total, and 11.65%, 10.00%, 6.56%, 1.77%, and 0% in Jilin, Xinjiang, Heilongjiang, Inner Mongolia, and Zhejiang ...
May C. Chu, Pan-He Zhang, Zhong-Tao Xin, Wu-Chun Cao, Jun He, Fang Zhang, Xiao-Ming Wu, Qing Duan, Qiu-Min Zhao, Wei Liu, Hong Yang   +10 more
core   +1 more source

Francisella tularensis Endocarditis [PDF]

Clinical Infectious Diseases, 2000
C A, Tancik, J A, Dillaha
openaire   +2 more sources

Identification of Francisella novicida mutants that fail to induce prostaglandin E2 synthesis by infected macrophages.

Frontiers in Microbiology, 2013
Francisella tularensis is the causative agent of tularemia. We have previously shown that infection with F. tularensis Live Vaccine Strain (LVS) induces macrophages to synthesize prostaglandin E2 (PGE2). Synthesis of PGE2 by F.
Matthew Dale Woolard, Lydia M Barrigan, Lydia M Barrigan, James R Fuller, Adam S Buntzman, Joshua eBryan, Colin eManoil, Tom eKawula, Jeffrey A Frelinger   +8 more
doaj   +1 more source

Francisella tularensis: No Evidence for Transovarial Transmission in the Tularemia Tick Vectors Dermacentor reticulatus and Ixodes ricinus.

PLoS ONE, 2015
BackgroundTularemia is a zoonosis caused by the Francisella tularensis, a highly infectious Gram-negative coccobacillus. Due to easy dissemination, multiple routes of infection, high environmental contamination and morbidity and mortality rates ...
Marco Genchi, Paola Prati, Nadia Vicari, Andrea Manfredini, Luciano Sacchi, Emanuela Clementi, Claudio Bandi, Sara Epis, Massimo Fabbi   +8 more
doaj   +1 more source