Results 71 to 80 of about 6,408 (161)
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Antimicrobial resistance highlights the urgent need for novel FabI inhibitors. Using an integrated computational approach combining ConPhar pharmacophore modeling, FTMap surface mapping, and PLIP interaction profiling across experimental structures and structures from MD simulations, we identified a conserved binding core (Y156/Y157, A95) and ...
Pedro Tenório T. F. Leite +10 more
wiley +1 more source
Mechanisms of Francisella tularensis Intracellular Pathogenesis
, 2013 Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the debilitating febrile illness tularemia. Although natural infections by F.
Celli, Jean, Zahrt, Thomas C
core +1 more source
Ekologija, domaćini i vektori bakterije Francisella tularensis [PDF]
, 2009 Francisella tularensis is a gram-negative facultative intracellular bacterium that can cause a fatal disease, tularaemia, in human and animals. Francisella tularensis survives for months on very low temperatures, in water, mud or dead animals.
Semić, Vildana +3 more
core +2 more sources
Point of Care Testing and Recombinase Polymerase Amplification
Journal of Clinical Laboratory Analysis, EarlyView.
Manfred Weidmann, Ahmed Abd El Wahed
wiley +1 more source
Archiv der Pharmazie, Volume 359, Issue 8, August 2026.This review provides a comprehensive analysis of the molecular modifications applied to NSAIDs to develop novel antimicrobial agents. By focusing on structural changes and their impact on biological activity, the study highlights innovative strategies to combat the global challenge of antimicrobial resistance.
Ebru Koçak Aslan +2 more
wiley +1 more source
BMC Genomics, 2012 Background Francisella tularensis is an intracellular pathogen that causes tularemia in humans and the public health importance of this bacterium has been well documented in recent history. Francisella philomiragia, a distant relative of F.
Siddaramappa Shivakumara +4 more
doaj +1 more source
Electrochemical Science Advances, Volume 6, Issue 4, August 2026.ABSTRACT Rapid and sensitive detection of disease‐related biomarkers is critical for early diagnosis and appropriate treatment. However, conventional analytical methods are often time‐consuming and require complex procedures and skilled personnel.
Minju Ahn +4 more
wiley +1 more source
Azithromycin effectiveness against intracellular infections of
BMC Microbiology, 2010 Background Macrolide antibiotics are commonly administered for bacterial respiratory illnesses. Azithromycin (Az) is especially noted for extremely high intracellular concentrations achieved within macrophages which is far greater than the serum ...
Mann Barbara J +4 more
doaj +1 more source
Francisella species in ticks and animals, Iberian Peninsula
, 2016 The presence of Francisella species in 2134 ticks, 93 lagomorphs and 280 small mammals from the Iberian Peninsula was studied. Overall, 19 ticks and 6 lagomorphs were positive for Francisella tularensis subsp.
Escudero, R. +12 more
core +1 more source
De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence
MicrobiologyOpen, Volume 15, Issue 4, August 2026.Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi +2 more
wiley +1 more source