Results 151 to 160 of about 5,297,487 (306)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Flavor improvement of enzymatic oyster juice by sequential heating through the accumulation of free amino acids and volatile flavor compounds. [PDF]

Front Nutr
Wang J, Chen T, Jiang Y, Li C, Hou J, Huang X.   +5 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Proteolytic Activity of Commercial Thermophilic Starter Cultures and Changes in Protein Fractions and Free Amino Acids in Organic and Conventional Fermented Milk. [PDF]

Food Sci Nutr
Steinweg S, Zagorska J, Majore K, Komasilovs V, Radenkovs V, Ciprovica I.   +5 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Biological activity and quantitative determination of free amino acids from muskmelon (<i>Cucumis melo</i> L.) extracts. [PDF]

Front Pharmacol
Sulieman AME, Elamin SM, Alshammari M, Almarshidi F, Ibrahim SM, Saleh ZA, Mohamed HM, Badraoui R.   +7 more
europepmc   +1 more source

Fast Chromatographic Determination of Free Amino Acids in Bee Pollen. [PDF]

Foods, 2022
Martín-Gómez B, Salahange L, Tapia JA, Martín MT, Ares AM, Bernal J.   +5 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Rapid enantioselective fluorescence recognition and chiral separation of free amino acids. [PDF]

Nat Commun
Li Y, Yu K, Xu Z, Zeng J, Wei J, Jiang H, Zhu Y, Gu S, Ma X.   +8 more
europepmc   +1 more source

FREE AMINO ACIDS IN CEREBROSPINAL FLUID

Journal of Biological Chemistry, 1947
J D, SOLOMON, S W, HIER, O, BERGEIM
openaire   +3 more sources