Results 81 to 90 of about 758,630 (312)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Thermal degradation of 18 amino acids during pyrolytic processes

Scientific Reports
Biomass pyrolysis greatly impacts climates, ecosystem dynamics, air quality, human health, global carbon and nitrogen cycle. The emissions of nitrogen-containing compounds from biomass pyrolysis highly depend on the protein nitrogen existing in biomass ...
Ren-Guo Zhu, Hua-Yun Xiao, Zhongkui Zhou, Meiju Yin, Hao Xiao, Caixia Hu, Guo Wei, Cheng Liu   +7 more
doaj   +1 more source

Changes in the Amino Acid Composition of Bee-Collected Pollen During 15 Months of Storage in Fresh-Frozen and Dried Forms

Foods
Bee pollen (BP) is a nutritionally valuable natural product whose biological activity is strongly influenced by its amino acid profile. This study evaluated qualitative and quantitative changes in free amino acids in Lithuanian BP subjected to freezing (−
Aurita Bračiulienė, Rosita Stebuliauskaitė, Mindaugas Liaudanskas, Vaidotas Žvikas, Neringa Sutkevičienė, Sonata Trumbeckaitė   +5 more
doaj   +1 more source

Influence of lactic-acid bacteria feed supplementation on free amino acid levels in serum and feces of rainbow trout (Oncorhynchus mykiss, Walbaum 1792) [PDF]

, 2023
Gabriel Reis Alves Carneiro, Constanza Opazo, Gustavo Ramalho Cardoso dos Santos, Henrique Marcelo Gualberto Pereira, Gustavo Monnerat, Rafael Opazo   +5 more
openalex   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Difference of Free Amino Acids in Different Primary Processed Yunnan Arabica Coffee and Its Taste Forming Mechanism

Shipin gongye ke-ji
To explore the influence of three different primary processing methods (wet-processed, honey-processed and sun-exposed processed) of Yunnan Arabica coffee on the free amino acid and its taste forming mechanisms, the total protein content, free amino ...
Ziqi GAO, Zelin LI, Zhirui Niu, Xiuwei LIU, Yunhui SHAN, Fangyu FAN, Hao TIAN   +6 more
doaj   +1 more source

Assessment of seminal plasma free amino acids among fertile men

SVU - International Journal of Medical Sciences, 2019
Background:Amino acids can elevate sperm count, motility, and morphology. Increasing the availability of these amino acids can help to improve male fertility certain foods can help to improve sperm parameters.
Marwa O. Aboelwafa *, Tahia H. Seleem, Hassan M. Ibraheem, Mohammed H. Hassan   +3 more
doaj   +1 more source

Effects of protein‐free diet in amino acid homeostatis of rat blood plasma and gut contents [PDF]

, 1987
Slavica Suzić, L Radunović, Violeta Janković, R Segović   +3 more
openalex   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source