Results 101 to 110 of about 6,396,790 (306)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Effect of a high intake of conjugated linoleic acid on lipoprotein levels in healthy human subjects [PDF]

, 2010
Background -Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower high-density lipoprotein (HDL) cholesterol, raise low-density lipoprotein (LDL ...
Wanders Anne J., Siebelink, E., Brouwer, I.A.; id_orcid, Martijn B. Katan, Katan Martijn B., Martijn B Katan, Ingeborg A Brouwer, Brouwer, I.A., Els Siebelink, Anne J. W, Katan, M.B.; id_orcid, Katan, M.B., Anne J Wanders, Siebelink Els, Wanders, A.J., Ingeborg A. Brouwer, Brouwer Ingeborg A.   +16 more
core   +4 more sources

Serum free fatty acids levels not associated with normal tension glaucoma

Clinical Ophthalmology, 2010
Kenya Yuki, Itaru Kimura, Kazuo TsubotaDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, JapanPurpose: To determine the free fatty acid levels in the sera of patients with normal-tension glaucoma and compare it with that of normal ...
Kenya Yuki, Itaru Kimura, Kazuo Tsubota
doaj  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Phospholipid fatty acid analysis to monitor the co-composting process of olive oil mill wastes and organic household refuse [PDF]

, 2008
The co-composting of olive oil mill wastes and household refuse was followed for 5 months. During the thermophilic phase of composting, the aerobic heterotrophic bacteria (AHB) count, showed a significant rise with a slight regression of fungal biomass ...
Amir, Soumia, Cegarra, Juan, Hafidi, Mohamed, Pinelli, Eric, Merlina, Georges, Winterton, Peter, Barje, Farid, Revel, Jean-Claude   +7 more
core   +1 more source

Effect of glucose ingestion on the metabolism of free fatty acids in human subjects

Journal of Lipid Research, 1969
The rate of appearance of 14CO2 in expired air after the injection of a single dose of NaH14CO3 has been determined in normal individuals both in the fasted and fed states.
C. Waterhouse, N. Baker, H. Rostami
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21 [PDF]

, 2009
OBJECTIVE—Fibroblast growth factor (FGF)-21 improves insulin sensitivity and lipid metabolism in obese or diabetic animal models, while human studies revealed increased FGF-21 levels in obesity and type 2 diabetes.
Pfeiffer, Andreas F. H., Meinus, S., Andres, Janin, Biedasek, Katrin, Biedasek, K., Spranger, J., Mai, K., Reinecke, F., Spuler, S., Pfeiffer, A.F., Moehlig, M., Sabath, Markus, Clemenz, M., Mai, Knut, Bobbert, T., Meinus, Sabine, Spranger, Joachim, Reinecke, Franziska, Weickert, Martin O., Bobbert, Thomas, Weicht, J., Möhlig, Matthias, Andres, J., Weicht, Jessica, Kintscher, U., Spuler, Simone, Clemenz, Markus, Sabath, M., Weickert, M.O., Kintscher, Ulrich   +29 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Freezing, roasting and salt dipping impacts on peroxide value, free fatty acid and fatty acid concentrations of nut kernels

, 2019
Tree nuts are rich in unsaturated fatty acids and nuts have human health benefits. It is important that postharvest processing does not negatively impact nut fatty acid composition and nut oil quality. Canarium indicum (Burseraceae) is an indigenous tree
Hannet, D, Hannet, G, Jones, K, Walton, DA, Wallace, HM, Nevenimo, T, Trueman, SJ, Randall, B, Bai, SH, Grant, EL   +9 more
core   +1 more source